CNS Drugs

, Volume 20, Issue 3, pp 233–255 | Cite as


A Review of its Use in Schizophrenia
Adis Drug Evaluation



Oral sertindole (Serdolect®) is an atypical antipsychotic approved in the EU for once-daily use in patients with schizophrenia who are intolerant to at least one other antipsychotic agent.

Extensive data from post-marketing studies do not indicate an excess of overall mortality with sertindole. Sertindole is at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS). Thus, sertindole is a useful option in the treatment of patients with schizophrenia.

Pharmacological Properties

The fundamental mechanism of sertindole action is considered to be selective inhibition of dopamine D2 receptors in the mesolimbic system (ventral tegmental area) versus the nigrostriatum, together with inhibition of CNS serotonin 5-HT2 receptors and α1-adrenoceptors. Although sertindole is associated with QT interval prolongation, it appears that the drug has counter-regulatory properties that protect against ventricular arrhythmias. Sertindole had beneficial effects on cognitive functioning in animal models.

Sertindole is slowly absorbed after oral administration with a time to the maximum plasma concentration of ≈10 hours. The oral bioavailability of sertindole is ≈75%. Sertindole undergoes extensive hepatic metabolism by cytochrome P450 (CYP) 2D6 and CYP3A4 to two principal metabolites, dehydrosertindole and norsertindole. CYP2D6 poor metabolisers may have sertindole clearance reduced by ≈50–67%. Sertindole is almost completely eliminated in the faeces, with a mean terminal elimination half-life of 53–102 hours. Concomitant administration of sertindole and drugs that induce CYP isozymes may result in reduced plasma sertindole concentrations. The concomitant administration of sertindole and potent CYP3A inhibitors is contraindicated and sertindole should be used in combination with CYP2D6 inhibitors with extreme caution.

Therapeutic Efficacy

The efficacy of oral sertindole administered once daily to patients with schizophrenia has been examined in several randomised, double-blind trials.

Sertindole was effective in the treatment of neuroleptic-responsive schizophrenia, according to the results of a placebo-controlled dose-ranging study. Significantly greater improvements from baseline in Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) total scores were seen in recipients of sertindole 20 mg/day compared with placebo. In addition, the Clinical Global Impression-Improvement (CGI-I) score was significantly lower with sertindole 20 mg/day than with placebo.

Sertindole was at least as effective as haloperidol in the treatment of neuroleptic-responsive schizophrenia, according to the results of four trials. Significant improvements from baseline in PANSS and BPRS total scores were seen with both sertindole 12–24 mg/day (i.e. therapeutic dosages) and haloperidol 4–16 mg/day compared with placebo after 8 weeks’ treatment. No significant differences were seen between sertindole (at therapeutic dosages) and haloperidol in terms of improvements from baseline in PANSS or BPRS total scores after 8 or 52 weeks’ treatment. Compared with placebo, CGI-I scores at study end were significantly better with sertindole 12–24 mg/day and haloperidol 8 and 16 mg/day, with no significant difference between the active treatment groups. Significant improvements from baseline in the PANSS positive symptom subscale score occurred with sertindole 20 and 24 mg/day and haloperidol 4–16 mg/day compared with placebo, with no significant differences between sertindole (at therapeutic dosages) and haloperidol. Only sertindole 20 mg/day demonstrated a significantly greater improvement in both PANSS negative symptom subscale and Scale for the Assessment of Negative Symptoms (SANS) total scores, compared with placebo. There were generally no significant differences between active treatment groups in PANSS negative symptom subscale or SANS total scores after 8 weeks’ treatment, although the change from baseline in the PANSS negative component subscale score significantly favoured recipients of sertindole 16 mg/day versus haloperidol in one trial. In the longer-term trial, sertindole reduced the SANS total score from baseline significantly more than haloperidol after 2 months’ treatment, although there was no significant between-group difference after 12 months. In this trial, time to treatment failure was not significantly different between sertindole and haloperidol recipients. However, over 1 year, the times to psychotic decompensation with associated hospitalisation and to premature treatment discontinuation because of patient nonadherence were significantly longer in the sertindole than in the haloperidol group. Sertindole also improved aspects of cognitive functioning in patients with schizophrenia.

Sertindole was at least as effective as risperidone in patients with schizophrenia, according to the results of two trials. There was no significant difference between sertindole and risperidone recipients in the improvement from baseline in the PANSS total score in either patients with treatment-responsive or -refractory schizophrenia after 12 weeks’ treatment, according to the intent-to-treat last-observation-carried-forward analysis. However, in one of these trials, the observed cases analysis revealed a significantly greater decrease in PANSS total score in sertindole than risperidone recipients, as did a repeated-measurement analysis. Sertindole had similar efficacy to risperidone in terms of improvements from baseline in PANSS positive symptom subscale and CGI-Severity scores. In terms of PANSS negative symptom subscale scores, no significant difference between sertindole and risperidone recipients was seen in one study, although a significant difference favouring sertindole recipients was seen in the other trial.


From a tolerability database of approximately 2500 sertindole-treated patients, approximately 90% of patients experienced at least one treatment-emergent adverse event, yet the overall rate of treatment withdrawal because of such events was low. The most commonly occurring adverse events in sertindole recipients included headache, insomnia, rhinitis and abnormal ejaculation (i.e. decreased ejaculatory volume) in men.

Sertindole is associated with moderate weight gain (≈3kg) but is not associated with sedation or anticholinergic-mediated cognitive impairment, and did not increase plasma prolactin levels above the normal reference range. Only 4% of patients had clinically significant increases in serum glucose levels.

Both clinical trial data and epidemiological data revealed sertindole recipients to have all-cause mortality rates that were low (1.52 [95% CI 0.96, 2.13] per 100 patient-years of exposure [PYE] in clinical trials and 0.48 [95% CI 0.21, 0.94] to 2.34 [95% CI 0.94, 4.83] per 100 PYE in epidemiological studies) and generally similar to those in patients receiving other antipsychotics. Suicide rates among sertindole recipients were 0.37 (95% CI 0.15, 0.75) per 100 PYE in clinical trials and 0.12 to 0.73 (95% CI 0.15, 2.12) per 100 PYE in epidemiological studies. Cardiac mortality rates in sertindole recipients were also low (0.31 [95% CI 0.11, 0.68] per 100 PYE in clinical trials and 0.0–0.37 per 100 PYE in epidemiological studies) and similar to those seen in patients receiving other antipsychotics. There were no cases of ventricular arrhythmias or torsade de pointes reported in clinical trials or in epidemiological studies.

Sertindole was associated with a low rate of EPS-related adverse events, with no significant difference between sertindole and placebo recipients, according to the results of clinical trials. By contrast, haloperidol was generally associated with a significantly higher incidence of EPS-related adverse events than sertindole. Rates of medication use to control EPS were similar with sertindole and placebo and significantly lower with sertindole than with haloperidol. Changes from baselines in movement rating scale scores were generally similar in sertindole and placebo or risperidone recipients, although significantly greater improvements from baseline in Abnormal Involuntary Movement Scale, Barnes Akathisia Scale and Simpson-Angus Scale scores were seen with sertindole than with haloperidol.

Pharmacoeconomic Considerations

Sertindole dominated both haloperidol and olanzapine over a 10-year period, according to the results of a Markov modelling study. In addition, prospective collection of resource utilisation data during a 1-year study revealed cost savings with sertindole compared with haloperidol in outpatients with schizophrenia. Sertindole also appeared to be associated with reductions in healthcare resource use in a nonblind, partly retrospective study.


Schizophrenia Haloperidol Risperidone Olanzapine Brief Psychiatric Rate Scale 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Peuskens J. Introduction to sertindole in clinical practice. CNS Drugs 2004; 18Suppl. 2: 1–4PubMedCrossRefGoogle Scholar
  2. 2.
    National Institute for Clinical Excellence. Guidance on the use of newer (atypical) antipsychotic drugs for the treatment of schizophrenia [online]. Available from URL: [Accessed 2005 Dec 5]
  3. 3.
    Lublin H, Eberhard J, Levander S. Current therapy issues and unmet clinical needs in the treatment of schizophrenia: a review of the new generation antipsychotics. Int Clin Psychopharmacol 2005 Jul; 20(4): 183–98PubMedCrossRefGoogle Scholar
  4. 4.
    Falkai P, Wobrock T, Lieberman J, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia (Pt 1): acute treatment of schizophrenia. World J Biol Psychiatry 2005; 6(3): 132–91PubMedCrossRefGoogle Scholar
  5. 5.
    Kasper S, Hale A, Azorin J-M, et al. Benefit-risk evaluation of olanzapine, risperidone and sertindole in the treatment of schizophrenia. Eur Arch Psychiatry Clin Neurosci 1999; 249Suppl 2: II2–II14Google Scholar
  6. 6.
    National Institute for Clinical Excellence. Schizophrenia: core interventions in the treatment and management of schizophrenia in primary and secondary care [online]. Available from URL: [Accessed 2005 Dec 5]
  7. 7.
    Brown CS, Markowitz JS, Moore TR, et al. Atypical antipsychotics (Pt II): adverse effects, drug interactions, and costs. Ann Pharmacother 1999 Feb; 33(2): 210–7PubMedCrossRefGoogle Scholar
  8. 8.
    Naber D, Lambert M. Sertindole decreases hospitalization and improves the quality of life of schizophrenic patients. Int J Psychiatry Clin Pract 1998; 2Suppl. 2: S73–7Google Scholar
  9. 9.
    Olanzapine, sertindole and schizophrenia. Drug Ther Bull 1997 Nov; 35(11): 81–3CrossRefGoogle Scholar
  10. 10.
    Perquin L, Steinert T. A review of the efficacy, tolerability and safety of sertindole in clinical trials. CNS Drugs 2004; 18Suppl. 2: 19–30PubMedCrossRefGoogle Scholar
  11. 11.
    Moore N. Higher cardiovascular mortality with sertindole in ADROIT: a signal not confirmed. Int J Psychiatry Clin Pract 2002; 6Suppl. 1: S3–9CrossRefGoogle Scholar
  12. 12.
    H. Lundbeck A/S. European authorities approve marketing of Serdolect® [media release]. 2005 Apr 25Google Scholar
  13. 13.
    H. Lundbeck A/S. Launch of Serdolect® commenced in Europe [online]. Available from URL: [Accessed 2006 Jan 20]
  14. 14.
    Hyttel J, Nielsen JB, Nowak G. The acute effect of sertindole on brain 5-HT2, D2 and α1 receptors (ex vivo radioreceptor binding studies). J Neural Transm Gen Sect 1992; 89(1–2): 61–9PubMedCrossRefGoogle Scholar
  15. 15.
    Sánchez C, Arnt J, Dragsted N, et al. Neurochemical and in vivo pharmacological profile of sertindole, a limbic-selective neuroleptic compound. Drug Dev Res 1991; 22(3): 239–50CrossRefGoogle Scholar
  16. 16.
    Skarsfeldt T. Pharmacology of sertindole, a novel atypical neuroleptic. In: Brunello N, Mendlewicz J, Racagni G, editors. New generation of antipsychotic drugs: novel mechanisms of action. Basel: S. Karger, 1993: 62–6Google Scholar
  17. 17.
    Richelson E, Souder T. Binding of antipsychotic drugs to human brain receptors: focus on newer generation compounds. Life Sci 2000 Nov 24; 68(1): 29–39PubMedCrossRefGoogle Scholar
  18. 18.
    Herrick-Davis K, Grinde E, Teitler M. Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxy-tryptamine2C receptors. J Pharmacol Exp Ther 2000 Oct; 295(1): 226–32PubMedGoogle Scholar
  19. 19.
    Hietala J, Kuoppamäki M, Majasuo H, et al. Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment. Psychopharmacology (Berl) 2001 Sep; 157(2): 180–7CrossRefGoogle Scholar
  20. 20.
    Arnt J. Sertindole and several antipsychotic drugs differentially inhibit the discriminative stimulus effects of amphetamine, LSD and ST-587 in rats. Behav Pharmacol 1992; 3: 11–8PubMedCrossRefGoogle Scholar
  21. 21.
    Casey DE. Behavioral effects of sertindole, risperidone, clozapine and haloperidol in Cebus monkeys. Psychopharmacology (Berl) 1996 Mar; 124(1–2): 134–40CrossRefGoogle Scholar
  22. 22.
    Petit-Taboué M-C, Landeau B, Barré L, et al. Parametric PET imaging of 5HT2A receptor distribution with 18F-setoperone in the normal human neocortex. J Nucl Med 1999 Jan; 40(1): 25–32PubMedGoogle Scholar
  23. 23.
    Nyberg S, Olsson H, Nilsson U, et al. Low striatal and extra-striatal D2 receptor occupancy during treatment with the atypical antipsychotic sertindole. Psychopharmacology (Berl) 2002 Jun 1; 162: 37–41CrossRefGoogle Scholar
  24. 24.
    Kongsamut S, Kang J, Chen X-L, et al. A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. Eur J Pharmacol 2002 Aug 16; 450(1): 37–41PubMedCrossRefGoogle Scholar
  25. 25.
    Rampe D, Murawsky MK, Grau J, et al. The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG. J Pharmacol Exp Ther 1998 Aug; 286(2): 788–93PubMedGoogle Scholar
  26. 26.
    Lindström E, Farde L, Eberhard J, et al. QTc interval prolongation and antipsychotic drug treatments: focus on sertindole. Int J Neuropsychopharmacol 2005; 8: 615–29PubMedCrossRefGoogle Scholar
  27. 27.
    Haverkamp W, Eckardt L, Matz J. Sertindole: cardiac electrophysiological profile. Int J Psychiatry Clin Pract 2002; 6Suppl. 1: S11–20CrossRefGoogle Scholar
  28. 28.
    Titier K, Canal M, Déridet E, et al. Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice. Toxicol Appl Pharmacol 2004 Aug 15; 199(1): 52–60PubMedCrossRefGoogle Scholar
  29. 29.
    Rodefer J. The effects of antipsychotics on reversing PCP-induced deficits in a rodent attentional set-shifting task [abstract]. XIIIth Biennial Winter Workshop on Schizophrenia Research; 2006 Feb 4–10; DavosGoogle Scholar
  30. 30.
    Didriksen M. Sertindole shows advantageous cognitive profile in the Morris water maze [poster]. 9th International Congress on Schizophrenia Research; 2003 Mar 29–Apr 2; Colorado Springs (CO)Google Scholar
  31. 31.
    Didriksen M. Effects of antipsychotics on cognitive behaviour in rats using the delayed non-match position paradigm. Eur J Pharmacol 1995; 281: 241–50PubMedCrossRefGoogle Scholar
  32. 32.
    Arnt J, Skarsfeldt T. Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 1998; 18(2): 63–101PubMedCrossRefGoogle Scholar
  33. 33.
    Kasper S, Tauscher J, Küfferle B, et al. Sertindole and dopamine D2 receptor occupancy in comparison to risperidone, clozapine and haloperidol: a 123I-IBZM SPECT study. Psychopharmacology (Berl) 1998 Apr; 136: 367–73CrossRefGoogle Scholar
  34. 34.
    Pilowsky LS, O’Connell P, Davies N, et al. In vivo effects on striatal dopamine D2 receptor binding by the novel atypical antipsychotic drug sertindole: a 123I IBZM single photon emission tomography (SPET) study. Psychopharmacology (Berl) 1997 Mar; 130: 152–8CrossRefGoogle Scholar
  35. 35.
    Agelink MW, Majewski T, Wurthmann C, et al. Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine. J Clin Psychopharmacol 2001 Feb; 21(1): 8–13PubMedCrossRefGoogle Scholar
  36. 36.
    Eckardt L, Breithardt G, Haverkamp W. Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation. J Pharmacol Exp Ther 2002 Jan; 300(1): 64–71PubMedCrossRefGoogle Scholar
  37. 37.
    Thomsen MB, Volders PGA, Stengl M, et al. Electrophysiological safety of sertindole in dogs with normal and remodeled hearts. J Pharmacol Exp Ther 2003 Nov; 307(2): 776–84PubMedCrossRefGoogle Scholar
  38. 38.
    Ouellet D, Cao G, Staser J, et al. Population pharmacokinetics of sertindole in patients with schizophrenia [abstract no. PII-50] 98th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics; 1997 Mar 5–8; San Diego (CA)Google Scholar
  39. 39.
    Wong SL, Sebree T, Granneman GR. Dose-proportionality of sertindole after 4–16 mg single dose oral administration [abstract no. PPDM 8438]. Pharm Res 1996 Sep; 13(9 Suppl.): S502Google Scholar
  40. 40.
    Wong SL, Linnen P, Mack R, et al. Effects of food, antacid, and dosage form on the pharmacokinetics and relative bioavailability of sertindole in healthy volunteers. Biopharm Drug Dispos 1997 Aug; 18(6): 533–41PubMedCrossRefGoogle Scholar
  41. 41.
    Wong SL, Cao G, Mack RJ, et al. Pharmacokinetics of sertindole in healthy young and elderly male and female subjects. Clin Pharmacol Ther 1997 Aug; 62(2): 157–64PubMedCrossRefGoogle Scholar
  42. 42.
    Wong SL, Menacherry S, Mulford D, et al. Pharmacokinetics of sertindole and dehydrosertindole in volunteers with normal or impaired renal function. Eur J Clin Pharmacol 1997 May; 52: 223–7PubMedCrossRefGoogle Scholar
  43. 43.
    Markowitz JS, Brown CS, Moore TR. Atypical antipsychotics (Pt I): pharmacology, pharmacokinetics, and efficacy. Ann Pharmacother 1999 Jan; 33(1): 73–85PubMedCrossRefGoogle Scholar
  44. 44.
    Wong SL, Granneman GR. Modeling of sertindole pharmacokinetic disposition in healthy volunteers in short term dose-escalation studies. J Pharm Sci 1998 Dec; 87(12): 1629–31PubMedCrossRefGoogle Scholar
  45. 45.
    H. Lundbeck A/S. Sertindole: summary of product characteristics. Copenhagen: H. Lundbeck A/S 2005 SepGoogle Scholar
  46. 46.
    Data on file, H. Lundbeck A/S, 2006Google Scholar
  47. 47.
    Kane JM, Tamminga CA. Sertindole (Serdolect): preclinical and clinical findings of a new atypical antipsychotic. Expert Opin Invest Drugs 1997 Nov; 6(11): 1729–41CrossRefGoogle Scholar
  48. 48.
    Wong SL, Cao G, Mack RJ, et al. The effect of erythromycin on the CYP3A component of sertindole clearance in healthy volunteers. J Clin Pharmacol 1997 Nov; 37: 1056–61PubMedGoogle Scholar
  49. 49.
    Wong SL, Locke C, Staser J, et al. Lack of multiple dosing effect of sertindole on the pharmacokinetics of alprazolam in healthy volunteers. Psychopharmacology (Berl) 1998 Feb; 135: 236–41CrossRefGoogle Scholar
  50. 50.
    Wong SL, Cao G, Mack R, et al. Lack of CYP3A inhibition effects of sertindole on terfenadine in healthy volunteers. Int J Clin Pharmacol Ther 1998 Mar; 36(3): 146–51PubMedGoogle Scholar
  51. 51.
    van Kammen DP, McEvoy JP, Targum SD, et al. A randomized, controlled, dose-ranging trial of sertindole in patients with schizophrenia. Psychopharmacology (Berl) 1996 Mar; 124(1–2): 168–75PubMedCrossRefGoogle Scholar
  52. 52.
    Zimbroff DL, Kane JM, Tamminga CA, et al. Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Am J Psychiatry 1997 Jun; 154(6): 782–91PubMedGoogle Scholar
  53. 53.
    Hale A, Azorin J-M, Kasper S, et al. Sertindole improves both the positive and negative symptoms of schizophrenia: results of a phase III trial. Int J Psychiatry Clin Pract 2000 Mar; 4: 55–62CrossRefGoogle Scholar
  54. 54.
    Daniel DG, Wozniak P, Mack RJ, et al. Long-term efficacy and safety comparison of sertindole and haloperidol in the treatment of schizophrenia. Psychopharmacol Bull 1998; 34(1): 61–9PubMedGoogle Scholar
  55. 55.
    Lis S, Krieger S, Gallhofer B, et al. Sertindole is superior to haloperidol in cognitive performance in patients with schizophrenia: a comparative study [abstract no. P.2.100]. Eur Neuropsychopharmacol 2003 Sep; 13Suppl. 4: S323–4CrossRefGoogle Scholar
  56. 56.
    Kane J, Potkin S, Buckley P, et al. Safety and efficacy of sertindole and risperidone in treatment resistant patients with schizophrenia [abstract and poster]. 10th International Congress on Schizophrenia Research; 2005 Apr 2–6; Savannah (GA)Google Scholar
  57. 57.
    Azorin J-M, Strub N, Loft H. A double-blind, controlled study of sertindole versus risperidone in the treatment of moderate-to-severe schizophrenia. Int Clin Psychopharmacol 2006 Jan; 21(1): 49–56PubMedCrossRefGoogle Scholar
  58. 58.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed, revised. Washington, DC: American Psychiatric Association 1987Google Scholar
  59. 59.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association 1994Google Scholar
  60. 60.
    Leucht S, Pitschel-Walz G, Abraham D, et al. Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials. Schizophr Res 1999 Jan 4; 35: 51–68PubMedCrossRefGoogle Scholar
  61. 61.
    Steinert T, Hauger B, Eckardt J, et al. Clinical observations of sertindole in 53 hospitalised patients with psychotic disorders. Clin Drug Invest 2005; 25(1): 79–83CrossRefGoogle Scholar
  62. 62.
    Pezawas L, Quiner S, Moertl D, et al. Efficacy, cardiac safety and tolerability of sertindole: a drug surveillance. Int Clin Psychopharmacol 2000 Jul; 15(4): 207–14PubMedCrossRefGoogle Scholar
  63. 63.
    Raja M, Azzoni A. Naturalistic open study of sertindole in the treatment of patients with psychotic disorders. Minerva Psichiatr 2000; 41(4): 251–8Google Scholar
  64. 64.
    Hale A, Azorin J-M, Kasper S, et al. Sertindole is associated with a low level of extrapyramidal symptoms in schizophrenic patients: results of a phase III trial. Int J Psychiatry Clin Pract 2000 Mar; 4: 47–54CrossRefGoogle Scholar
  65. 65.
    Lewis R, Bagnall A-M, Leitner M. Sertindole for schizophrenia. Cochrane Database Syst Rev 2005; (3): CD001715Google Scholar
  66. 66.
    Kasper S, Toumi M. The clinical safety and tolerability profile of sertindole [abstract no. S422]. Int J Neuropsychopharmacol 2004 Jun; 7 Suppl. 1: S422 plus poster presented at the 24th Collegium Internationale Neuro-Psychopharmacologicum Congress; 2004 Jun 20–24; ParisGoogle Scholar
  67. 67.
    Mack R, Driscoll R, Silber C. The long term cardiovascular safety of sertindole [abstract no. P.2.042]. Eur Neuropsychopharmacol 1997 Sep; 7Suppl. 2: S207Google Scholar
  68. 68.
    Wilton LV, Heeley EL, Pickering RM, et al. Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antip-sychotic drugs, risperidone and olanzapine. J Psychopharmacol (Oxf) 2001; 15(2): 120–6CrossRefGoogle Scholar
  69. 69.
    Peuskens J, Moore N, Azorin J-M, et al. Sertindole safety and exposure: a retrospective study on 8,608 patients in Europe [poster]. 9th International Congress on Schizophrenia Research; 2003 Mar 29–Apr 2; Colorado Springs (CO)Google Scholar
  70. 70.
    Branford D, Thompson B, Muldoon C. Mortality in three comparative cohorts of patients who received sertindole, risperidone and olanzapine: a hospital-based, retrospective study [abstract no. 247]. Pharmacoepidemiol Drug Saf 2002 Aug; 11Suppl. 1: S116Google Scholar
  71. 71.
    Sturkenboom MCJM, Picelli G, Moore N. Mortality during use of sertindole and other anti-psychotics: a comparative cohort study [poster]. 9th International Congress on Schizophrenia Research; 2003 Mar 29–Apr 2; Colorado Springs (CO)Google Scholar
  72. 72.
    Kasper S, Möller H-J, Hale A. The European Post-marketing Observational Serdolect® (EPOS) study: an investigation of the safety of antipsychotic drug treatment. Copenhagen: H. Lundbeck A/S, 2006. (Data on file)Google Scholar
  73. 73.
    Toumi M, Auquier P, François C. Sertindole safety and tolerability in a patient named use programme [poster]. 9th International Congress on Schizophrenia Research; 2003 Mar 29–Apr 2; Colorado Springs (CO)Google Scholar
  74. 74.
    Toumi M, Mann R, Hall G, et al. Mortality associated with sertindole: review of epidemiological studies [abstract no. NR560 plus poster]. American Psychiatric Association 2003 Annual Meeting; 2003 May 17–22; San Francisco (CA)Google Scholar
  75. 75.
    Fournier A, Zureik M, François C. Risk factors for death in schizophrenic patients: a nested case control study [poster]. 18th International Conference on Pharmacoepidemiology; 2002 Aug 18–21; EdinburghGoogle Scholar
  76. 76.
    Lançon C, Launois R, von der Schulenburg MG. Sertindole: cost and effectiveness assessment [poster]. 7th International Conference on Schizophrenia Research; 1999 Apr 17–21; Santa Fe (NM)Google Scholar
  77. 77.
    Ereshefsky L, Toumi M, François C. Association of sertindole with reduction in healthcare resource use by patients with schizophrenia [poster]. 9th International Congress on Schizophrenia Research; 2003 Mar 29–Apr 2; Colorado Springs (CO)Google Scholar
  78. 78.
    European Agency for the Evaluation of Medicinal Products. Points to consider: the assessment of the potential for QT interval prolongation by non-cardiovascular medicinal products [online]. Available from URL: [Accessed 2006 Jan 20]
  79. 79.
    Hale A. Sertindole: a clinical efficacy profile. Int J Psychiatry Clin Pract 2002; 6Suppl. 1: S21–6CrossRefGoogle Scholar
  80. 80.
    Hellewell JSE. Treatment-resistant schizophrenia: reviewing the options and identifying the way forward. J Clin Psychiatry 1999; 60 Suppl. 23: 14–9Google Scholar
  81. 81.
    Emsley R, Oosthuizen P. The new and evolving pharmacotherapy of schizophrenia. Psychiatr Clin North Am 2003; 26: 141–63PubMedCrossRefGoogle Scholar

Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  1. 1.Adis International LimitedMairangi Bay, AucklandNew Zealand

Personalised recommendations