CNS Drugs

, Volume 19, Issue 1, pp 55–61 | Cite as

Intramuscular Interferon-β-1a

In Patients at High Risk of Developing Clinically Definite Multiple Sclerosis
  • M. Asif A. Siddiqui
  • Keri Wellington
Adis Drug Profile


▴ Intramuscular interferon-β-1a, a recombinant interferon-β approved in the US for the treatment of relapsing forms of multiple sclerosis (MS), has also been evaluated in the treatment of patients with a first clinical demyelinating episode and brain lesions consistent with MS confirmed by magnetic resonance imaging (MRI).

▴ In a randomised, double-blind trial, patients at high risk of developing clinically definite MS who received intramuscular interferon-β-1a 30μg once weekly had a 44% reduction in the cumulative probability of developing MS, compared with placebo recipients (rate ratio 0.56; p = 0.002), over a 3-year period after a first, MRI-confirmed demyelinating event.

▴ These results were supported by MRI findings that showed significantly smaller increases in the volume of brain lesions and the number of new/enlarging and gadolinium-enhancing lesions in interferon-β-1a recipients than in those receiving placebo.

▴ A nonblind extension of this trial demonstrated that early treatment with interferon-β-1a significantly reduced the probability of developing MS by 35% (p = 0.03), compared with delayed treatment, over a 5-year period.

▴ Intramuscular interferon-β-1a was generally well tolerated; however, influenza-like syndrome was documented in >50% of patients at high risk of developing clinically definite MS who received the drug.


Multiple Sclerosis Magnetic Resonance Imaging Scan Optic Neuritis Avonex Definite Multiple Sclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  • M. Asif A. Siddiqui
    • 1
  • Keri Wellington
    • 1
  1. 1.Adis International LimitedMairangi BayNew Zeland

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