CNS Drugs

, Volume 8, Issue 3, pp 199–202 | Cite as

Is Once Weekly Administration of Antidepressants Feasible?

Experience with Fluoxetine
  • William J. Burke
  • Shelton E. Hendricks
  • Delores McArthur-Campbell
Current Opinion


Antidepressant medications are taken daily or more frequently based on both tradition and pharmacokinetics of the drugs. However, weekly administration may be a feasible option for drugs with a long elimination half-life and flat dose-response curve. In addition to providing effective control of symptoms, it is possible that weekly administration could also benefit patients by reducing costs and minimising drug interactions and adverse effects. The selective serotonin (5-hydroxytryptamine: 5-HT) reuptake inhibitor fluoxetine appears to be a candidate for once weekly administration.


Fluoxetine Weekly Administration Recurrent Depression Fluoxetine Treatment Nebraska Medical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cushing H. Life of Sir William Osler. Vol. 1. Oxford: Clarendon Press, 1925Google Scholar
  2. 2.
    Frank E, Kupfer DJ, Perel JM, et al. Three-year outcomes for maintenance therapies in recurrent depression. Arch Gen Psychiatry 1990; 47: 1093–9PubMedCrossRefGoogle Scholar
  3. 3.
    Thase ME, Fava M, Halbreich U, et al. A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia. Arch Gen Psychiatry 1996; 53: 777–84PubMedCrossRefGoogle Scholar
  4. 4.
    Kupfer DJ, Frank E, Perel JM, et al. Five-year outcome for maintenance therapies in recurrent depression. Arch Gen Psychiatry 1992; 49: 769–73PubMedCrossRefGoogle Scholar
  5. 5.
    Montgomery SA, Dufour H, Brion S, et al. The prophylactic efficacy of fluoxetine in unipolar depression. Br J Psychiatry 1988; 153(3 Suppl.): 69–76Google Scholar
  6. 6.
    Montgomery SA, James D, De Ruiter M, et al. Weekly oral fluoxetine treatment of major depressive disorder. Presented at the 15th Collegium Internationale Neuro-Psychopharmacologicum Congress; 1986 Dec 14-17; Puerto RicoGoogle Scholar
  7. 7.
    Van Harten J. Clinical pharmacokinetics of selective serotonin reuptake inhibitors. Clin Pharmacokinet 1993; 24(3): 203–20PubMedCrossRefGoogle Scholar
  8. 8.
    Preskorn SH, Magnus RD. Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: in vitro and in vivo findings and their implications for patient care. Psychopharmacol Bull 1994: 30(2): 251–9PubMedGoogle Scholar
  9. 9.
    Wernicke SF, Dunlop SR, Dornseif BE, et al. Low-dose fluoxetine therapy for depression. Psychopharmacol Bull 1988; 24(1): 183–8PubMedGoogle Scholar
  10. 10.
    Beasley CM, Bosomworth JC, Wernicke JF. Fluoxetine: relationships among dose. response. adverse events, and plasma concentrations in the treatment of depression. Psychopharmacol Bull 1990; 26(1): 18–24PubMedGoogle Scholar
  11. 11.
    Burke WJ, Hendricks SE, McArthur-Campbell DA, et al. Weekly fluoxetine controls symptoms of depression [abstract no. NR169]. American Psychiatric Association: 1995 Annual Meeting New Research Program and Abstracts. American Psychiatric Association 148th Annual Meeting; 1995 May 20-25; MiamiGoogle Scholar
  12. 12.
    Burke WJ, Hendricks SE, McArthur-Campbell DA, et al. Fluoxetine and norfluoxetine serum concentrations and clinical response in weekly versus daily dosing. Psychopharmacol Bull 1996; 32(1): 27–32PubMedGoogle Scholar

Copyright information

© Adis International Limited 1997

Authors and Affiliations

  • William J. Burke
    • 1
  • Shelton E. Hendricks
    • 1
  • Delores McArthur-Campbell
    • 1
  1. 1.Psychopharmacology Research Center, Creighton-Nebraska Department of Psychiatry, University of Nebraska Medical CenterOmahaUSA

Personalised recommendations