Is Once Weekly Administration of Antidepressants Feasible?
- 28 Downloads
Antidepressant medications are taken daily or more frequently based on both tradition and pharmacokinetics of the drugs. However, weekly administration may be a feasible option for drugs with a long elimination half-life and flat dose-response curve. In addition to providing effective control of symptoms, it is possible that weekly administration could also benefit patients by reducing costs and minimising drug interactions and adverse effects. The selective serotonin (5-hydroxytryptamine: 5-HT) reuptake inhibitor fluoxetine appears to be a candidate for once weekly administration.
KeywordsFluoxetine Weekly Administration Recurrent Depression Fluoxetine Treatment Nebraska Medical
Unable to display preview. Download preview PDF.
- 1.Cushing H. Life of Sir William Osler. Vol. 1. Oxford: Clarendon Press, 1925Google Scholar
- 5.Montgomery SA, Dufour H, Brion S, et al. The prophylactic efficacy of fluoxetine in unipolar depression. Br J Psychiatry 1988; 153(3 Suppl.): 69–76Google Scholar
- 6.Montgomery SA, James D, De Ruiter M, et al. Weekly oral fluoxetine treatment of major depressive disorder. Presented at the 15th Collegium Internationale Neuro-Psychopharmacologicum Congress; 1986 Dec 14-17; Puerto RicoGoogle Scholar
- 11.Burke WJ, Hendricks SE, McArthur-Campbell DA, et al. Weekly fluoxetine controls symptoms of depression [abstract no. NR169]. American Psychiatric Association: 1995 Annual Meeting New Research Program and Abstracts. American Psychiatric Association 148th Annual Meeting; 1995 May 20-25; MiamiGoogle Scholar