CNS Drugs

, Volume 6, Issue 5, pp 358–366 | Cite as

Brain Abscesses

Current Treatment Options
  • Murat Akova
Disease Management

Summary

Brain abscesses are relatively infrequent encounters during daily practice. However, clinicians are urged to diagnose the disease early and treat patients promptly because of the high risk of mortality and morbidity associated with any delay.

Since the availability of computed tomography (CT), the diagnosis and treatment of patients with brain abscesses has improved dramatically. The combination of surgical and medical management has reduced the mortality rate for this disease from 40 to 60% in the pre-CT era to the current rate of 0 to 6%. While stereotaxic aspiration and drainage of the abscesses have revolutionised surgical treatment, new broad-spectrum antibacterials with good penetration into the brain abscess cavity have further improved the outcome of treatment. In selected cases, nonsurgical management alone can be completed successfully with various third generation cephalosporins, metronidazole, or β-lactam/β-lactamase inhibitor combinations. By these means, effective treatment has become a reality in multiple cerebral abscesses that have a deep-seated location, a condition that once carried a very high mortality

Keywords

Metronidazole Infective Endocarditis Bacterial Meningitis Brain Abscess Antibacterial Therapy 

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Copyright information

© Adis International Limited 1996

Authors and Affiliations

  • Murat Akova
    • 1
  1. 1.Department of Medicine, Section of Infectious DiseasesHacettepe University School of MedicineAnkaraTurkey

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