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Programmed Cell Death in Cerebral Ischaemia

Therapeutic Implications

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Summary

Programmed cell death (PCD) is the process by which redundant neurons delete themselves during embryonic development in the nervous system. Recent data indicate that a cellular suicide process similar to PCD also contributes to the death of neurons during stroke. This suggests that pharmacological approaches that interrupt PCD may have utility in stroke. Three of these approaches are neurotrophins, endonuclease inhibitors and calpain inhibitors.

Each of these strategies has been demonstrated to inhibit PCD in different in vitro biological systems. They have also proven effective when administered to animals in which a stroke has been surgically induced. Thus, the strategy of inhibiting PCD to diminish damage during ischaemia appears to have merit, and is likely to continue to be a growing area of research that may lead to new and novel therapeutic approaches in acute and chronic neurodegenerative disorders.

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  1. Marion Merrell Dow Research Institute and Department of Neurosurgery, University of Cincinnati College of Medicine, 2110 East Galbraith Road, Cincinnati, Ohio, 45215-6300, USA

    Matthew D. Linnik

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Linnik, M.D. Programmed Cell Death in Cerebral Ischaemia. CNS Drugs 3, 239–244 (1995). https://doi.org/10.2165/00023210-199503040-00001

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