PharmacoEconomics

, Volume 12, Issue 1, pp 89–103 | Cite as

Cost-Utility Analysis of Melphalan plus Prednisone With or Without Interferon-α2b in Newly Diagnosed Multiple Myeloma

Results from a Randomised Controlled Trial
  • Erik Nord
  • Finn Wisøff
  • Martin Hjorth
  • Jan Westin
Original Research Article

Summary

This study evaluated the cost utility of adding interferon-α2b to conventional treatment in patients with multiple myeloma. It also provides a methodology for transforming complex quality-of-life profiles into a single index value on the conventional 0 to 1 quality-adjusted life-year scale (QALY).

From 1990 to 1992,583 patients with newly diagnosed, symptomatic multiple myeloma were enrolled in a randomised, multicentre, phase III study to evaluate the addition of interferon-α2b to treatment with melphalan and prednisone.

Addition of interferon-α2b yielded a 12% increase in median survival time, at the expense of a slight reduction in quality of life during the first year of treatment. The gain in survival time was not large enough to reach statistical significance. Patients receiving interferon-α2b also had a 5- to 6-month prolongation of the plateau phase.

Cost per QALY gained by adding interferon-α2b was conservatively estimated at $US110 000. Potentially better cost effectiveness may be found in different treatment regimens or in certain patient subgroups.

Keywords

Melphalan Multiple Myeloma Prednisone Health Profile Plateau Phase 

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Copyright information

© Adis Data Information BV 1997

Authors and Affiliations

  • Erik Nord
    • 1
  • Finn Wisøff
    • 2
  • Martin Hjorth
    • 3
  • Jan Westin
    • 4
  1. 1.National Institute of Public HealthOsloNorway
  2. 2.Department of HaematologyUllevål HospitalOsloNorway
  3. 3.Department of MedicineLidkøping HospitalLidkøpingSweden
  4. 4.Medical ClinicUniversity of LundLundSweden

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