, Volume 11, Issue 5, pp 408–418 | Cite as

Cost Considerations in the Pharmacological Prevention and Treatment of Stroke

  • Andrei V. Alexandrov
  • Liliana T. Smurawska
  • William Bartle
  • Paul Oh
Review Article


Stroke remains the leading cause of neurological disability and the third leading cause of death worldwide, consuming a large share of total healthcare expenditures.

In this review, we discuss the cost effectiveness of stroke prevention for various risk factor—modification programmes and pharmacological interventions with aspirin (acetylsalicylic acid), ticlopidine and warfarin. Cost considerations and potential cost savings resulting from acute treatment are discussed for parenterally administered anticoagulants, such as heparin and nadroparin, and for intravenous thrombolysis with alteplase (recombinant tissue plasminogen activator; r-tPA). Patients with multiple risk factors for stroke require more aggressive prevention strategies which are associated with a greater risk of complications. The rates of complications, particularly intracerebral haemorrhage, should be kept low to achieve cost benefits for warfarin and alteplase. Reduced hospital length of stay is the key factor in the implementation of cost-effective stroke therapies.

The analysis of future clinical trials of new stroke therapies should also include economic parameters, such as length of hospital stay and intensity of resource usage, to help guide formulary and therapeutic decisions.


Aspirin Atrial Fibrillation Warfarin Acute Stroke Acute Ischemic Stroke 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1997

Authors and Affiliations

  • Andrei V. Alexandrov
    • 1
  • Liliana T. Smurawska
    • 1
  • William Bartle
    • 1
  • Paul Oh
    • 1
  1. 1.Stroke Research Unit and the Division of Clinical Pharmacology, Sunnybrook Health Science CentreTorontoCanada

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