, Volume 9, Issue 6, pp 517–524 | Cite as

A Cost Analysis of Alprostadil in Liver Transplantation

  • Dean G. Smith
  • Keith S. Henley
  • Carl S. Remmert
  • Steven L. Hass
  • Darrell A. CampbellJr
  • I. Douglas McLaren
Original Research Article


Alprostadil (prostaglandin Ei) administration to liver transplant recipients has been shown to result in a significant reduction in the duration of hospital admission for transplantation, and in the need for re-operations (other than re-transplants) and renal support. To study the economic impact of this finding, we examined data from a controlled trial for all single-transplant surviving patients (42 alprostadil, 49 controls) for whom complete billing records were available for transplant days -2 to +150. All costs were measured in 1992 US dollars.

Patients given alprostadil had lower total charges [mean ± standard deviation (SD) $US175 297 ± $US70 652] than patients given placebo (mean ± SD $US225 672 ± $US187 208) [p = 0.043]. The data suggest that the use of alprostadil may have a significant favourable impact on the cost of liver transplantation.


Liver Transplantation Adis International Limited Orthotopic Liver Transplantation Professional Service Liver Transplant Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis Data Information BV 1996

Authors and Affiliations

  • Dean G. Smith
    • 1
  • Keith S. Henley
    • 2
  • Carl S. Remmert
    • 3
  • Steven L. Hass
    • 4
  • Darrell A. CampbellJr
    • 2
  • I. Douglas McLaren
    • 2
  1. 1.Department of Health Management and Policy, School of Public HealthUniversity of MichiganAnn ArborUSA
  2. 2.University of Michigan Medical School, University of MichiganAnn ArborUSA
  3. 3.University of Michigan Hospitals, University of MichiganAnn ArborUSA
  4. 4.The Upjohn CompanyKalamazooUSA

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