Advertisement

PharmacoEconomics

, Volume 5, Issue 5, pp 361–366 | Cite as

Pharmacoeconomics of Selective Decontamination of the Digestive Tract in Intensive Care Patients

A US Perspective
  • Susan J. Markowsky
  • Joan Christie
Leading Article

Keywords

Digestive Tract Intensive Care Unit Patient Norfloxacin Colistin Intensive Care Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aerdts SJA, Clasener HAL, van Dalen R, Van Lier HJJ, Vollaard EJ, et al. Prevention of bacterial colonization of the respiratory tract and stomach of mechanically ventilated patients by a novel regimen of selective decontamination in combination with initial systemic cefotaxime. Journal of Antimicrobial Chemotherapy 26(Suppl. A): 59–76, 1990PubMedCrossRefGoogle Scholar
  2. Atkinson SW, Bihari DJ. Selective decontamination of the gut: does not affect survival in intensive care units. British Medical Journal 306: 286–287, 1993PubMedCrossRefGoogle Scholar
  3. Blair P, Rowlands BJ, Lowry K, Webb H, et al. Selective decontamination of the digestive tract: a stratified, randomized, prospective study in a mixed intensive care unit. Surgery 110: 303–310, 1991PubMedGoogle Scholar
  4. Brun-Buisson C, Legrand P, Rauss A, et al. Intestinal decontamination for control of nosocomial multi-resistant gram-negative bacilli: a study of an outbreak in an intensive care unit. Annals of Internal Medicine 110: 873–881, 1989PubMedGoogle Scholar
  5. Cerra FB, Maddaus MA, Dunn DL, et al. Selective gut decontamination reduces nosocomial infections and length of stay but not mortality or organ failure in surgical intensive care unit patients. Archives of Surgery 127: 163–169, 1992PubMedCrossRefGoogle Scholar
  6. Cockerill FR, Muller SR, Anhalt JP, et al. Prevention of infection in critically ill patients by selective decontamination of the digestive tract. Annals of Internal Medicine 117: 545–553, 1992PubMedGoogle Scholar
  7. Craven DE. Use of selective decontamination of the digestive tract: is the light at the end of the tunnel red or green? Annals of Internal Medicine 117: 609–611, 1992PubMedGoogle Scholar
  8. Editorial. Emergence of resistance during selective decontamination of the digestive tract. European Journal of Clinical Microbiology and Infectious Diseases 11: 1–3, 1992Google Scholar
  9. Fink MP. Selective digestive decontamination: a gut issue for the nineties. Critical Care Medicine 20: 559–562, 1992PubMedCrossRefGoogle Scholar
  10. Gastinne H, Wolff M, Delatour F, et al. A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. New England Journal of Medicine 326: 594–599, 1992PubMedCrossRefGoogle Scholar
  11. Godard J, Guillaume C, Reverdy M-E, et al. Intestinal decontamination in a polyvalent ICU: a double-blind study. Intensive Care Medicine 16: 307–311, 1990PubMedCrossRefGoogle Scholar
  12. Gomez EC, Markowsky SJ, Rotschafer JC. Selective decontamination of the digestive tract in intensive care patients: review and commentary. Annals of Pharmacotherapy 26: 963–976, 1992PubMedGoogle Scholar
  13. Haley RW, Schaberg DR, Crossley KB, et al. Extra charges and prolongation of stay attributable to nosocomial infections: a prospective interhospital comparison. American Journal of Medicine 70: 51–58, 1981PubMedCrossRefGoogle Scholar
  14. Hammond JM, Potgieter PD, Saunders GL, et al. Double-blind study of selective decontamination of the digestive tract in intensive care. Lancet 340: 5–9, 1992PubMedCrossRefGoogle Scholar
  15. Hartenauer U, Thulig B, Diemer W, et al. Effect of selective flora suppression or colonization, infection, and mortality in critically ill patients: a one-year, prospective consecutive study. Critical Care Medicine 19: 463–473, 1991PubMedCrossRefGoogle Scholar
  16. Kerver AJH, Rommes JH, Mevissen-Verhage EAE, et al. Prevention of colonization and infection in critically ill patients: a prospective randomized study. Critical Care Medicine 16: 1087–1093, 1988PubMedCrossRefGoogle Scholar
  17. Koruda MJ. Gut sterilization to prevent nosocomial infection. New Horizons 2: 194–201, 1993Google Scholar
  18. Ledingham IM, Alcock SR, Eastaway AT, et al. Triple regimen of selective decontamination of the digestive tract, systemic cefotaxime, and microbiological surveillance for prevention of acquired infection in intensive care. Lancet 1: 785–790, 1988PubMedCrossRefGoogle Scholar
  19. Loirat P, Johanson WG, van Saene HK, et al. Selective digestive decontamination in intensive care unit patients. Intensive Care Medicine 18: 182–188, 1992CrossRefGoogle Scholar
  20. Mackie DP, van Hertum WAJ, Schumburg T, et al. Prevention of infection in burns: preliminary experience with selective decontamination of the digestive tract in patients with extensive injuries. Journal of Trauma 32: 570–575, 1992PubMedCrossRefGoogle Scholar
  21. Occhipint DJ, Itokazu G, Danziger LH. Selective decontamination of the digestive tract as an infection-control measure in intensive care unit patients. Pharmacotherapy 12(6 Pt. 2): 50S–63S, 1992Google Scholar
  22. Pugin J, Auckenthaler R, Lew DP, et al. Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. Journal of the American Medical Association 265: 2704–2710, 1991PubMedCrossRefGoogle Scholar
  23. Reidy JJ, Ramsay G. Clinical trials of selective decontamination of the digestive tract. Critical Care Medicine 18: 1449–1456, 1990PubMedCrossRefGoogle Scholar
  24. Silver MR, Bone RC. Selective digestive decontamination in critically ill patients. Critical Care Medicine 21: 1418–1420, 1993PubMedCrossRefGoogle Scholar
  25. Stoutenbeek CP. Topical antibiotic regimen. In van Saene et al. (Eds) Infection control by selective decontamination, pp. 95–101, Springer-Verlag, Berlin, 1988Google Scholar
  26. Stoutenbeek CP, van Saene HKF, Miranda DR, et al. The effect of selective decontamination of the digestive tract on colonization and infection rate in multiple trauma patients. Intensive Care Medicine 10: 185–192, 1984PubMedCrossRefGoogle Scholar
  27. Stoutenbeek CP, van Saene HKF, Miranda DR, et al. The effect of oropharyngeal decontamination using topical nonabsorbable antibiotics on the incidence of nosocomial respiratory tract infections in multiple trauma patients. Journal of Trauma 27: 357–364, 1987PubMedCrossRefGoogle Scholar
  28. Stoutenbeek CP, van Saene HKF, Zandstra DF. The effect of oral nonabsorbable antibiotics on the emergence of resistant bacteria in patients in an intensive care unit. Journal of Antimicrobial Chemotherapy 19: 513–520, 1987PubMedCrossRefGoogle Scholar
  29. Tettero GWM, Wagenvoort JHT, Castelein A, et al. Selective decontamination to reduce gram-negative colonization and infections after oesophageal resection. Lancet 335: 704–707, 1990CrossRefGoogle Scholar
  30. Trucksis M, Hooper DC, Wolfson JS. Emerging resistance to fluoroquinolones in staphylococci: an alert. Annals of Internal Medicine 114: 424–426, 1991PubMedGoogle Scholar
  31. Ulrich C, Harinck-de Weerd JE, Bakker NC, et al. Selective decontamination of the digestive tract with norfloxacin in the prevention of JCU-acquired infections: a prospective randomized study. Intensive Care Medicine 15: 424–431, 1989PubMedCrossRefGoogle Scholar
  32. Unertl K, Ruckdeschel G, Selbmann HK, et al. Prevention of colonisation and respiratory infections in long-term ventilated patients by local antimicrobial prophylaxis. Intensive Care Medicine 13: 106–113, 1987PubMedCrossRefGoogle Scholar
  33. Vandebroucke-Grauls CMJE, Vandenbroucke JJ. Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet 333: 859–862, 1991CrossRefGoogle Scholar
  34. van der Waaij D, Aberson J, Thijm HA, et al. The screening of four aminoglycosides in the selective decontamination of the digestive tract in mice. Infection 10: 35–48, 1982PubMedCrossRefGoogle Scholar
  35. van Saene HKJF, Stoutenbeek CP, Han CA. Selective decontamination of the digestive tract (SDD) in intensive care patients: a critical evaluation of the clinical, bacteriological and epidemiological benefits. Journal of Hospital Infection 18: 261–277, 1991PubMedCrossRefGoogle Scholar
  36. van Saene HKF, Stoutenbeek CC, Stoller JK. Selective decontamination of the digestive tract in the intensive care unit: current status and future prospects. Critical Care Medicine 20: 691–703, 1992PubMedCrossRefGoogle Scholar
  37. Verhoef J, Verhage EAE, Visser MR. A decade of experience with selective decontamination of the digestive tract as prophylaxis for infections in patients in the intensive care unit: what have we learned? Clinics in Infectious Diseases 17: 1047–1054, 1993CrossRefGoogle Scholar
  38. Weinstein RA. Selective intestinal decontamination - an infection control measure whose time has come? Annals of Internal Medicine 10: 853–855, 1989Google Scholar
  39. Wells CL. Editorial response to a decade of experience with selective decontamination of the digestive tract as prophylaxis for infections in patients in the intensive care unit: what have we learned? Clinics in infectious Diseases 17: 1055–1057, 1993CrossRefGoogle Scholar

Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • Susan J. Markowsky
    • 1
    • 3
  • Joan Christie
    • 2
  1. 1.Department of Pharmacotherapy and ResearchTampa General HospitalFloridaUSA
  2. 2.Department of AnesthesiologyTampa General Hospital, and University of South FloridaTampaUSA
  3. 3.Departments of Anesthesiology and SurgeryUniversity of South FloridaTampaUSA

Personalised recommendations