, Volume 5, Issue 3, pp 188–197 | Cite as

Clinical and Economic Factors in the Selection of Low-Osmolality Contrast Media

  • William H. MatthaiJr
Review Article


Both high- and low-osmolality contrast media are available for most radiographic procedures requiring iodinated contrast material. Newer low-osmolality contrast media cost much more than conventional high-osmolality formulations but cause fewer adverse reactions. However, most of these reactions are mild and easily treated, and do not affect the outcome of the procedure. Whether these additional clinical benefits justify the added cost is a crucial question which has not been answered. This review introduces some of the economic and clinical issues on which the choice of contrast media should be based, Low-osmality contrast agents are not cost effective considering current pricing strategies and current inability to select patients at increased risk of an adverse event. Therefore, a better understanding of these adverse events and their mechanism takes on added importance.


Contrast Agent Contrast Medium Severe Reaction Anaphylactoid Reaction Severe Adverse Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • William H. MatthaiJr
    • 1
  1. 1.Department of MedicineCooper Hospital/University Medical CenterCamdenUSA

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