Sports Medicine

, Volume 34, Issue 2, pp 81–90 | Cite as

Growth Hormone and Exercise Tolerance in Patients with Cystic Fibrosis

Leading Article


Cystic fibrosis (CF) is a life-limiting inherited disorder characterised by pulmonary disease, pancreatic dysfunction and symptoms of malnutrition that are all interrelated with low exercise capacity and poor survival rate. Therapy with growth hormone (GH) may improve the reduced dimensional and functional capacity associated with poor nutritional status and catabolism and therefore improve exercise tolerance, quality of life and survival rate in patients with CF. The literature about GH treatment and its effect on exercise tolerance are rather limited, not always consistent and methodological concerns restrict further analysis. GH treatment may have beneficial effects on both growth and exercise tolerance without serious complications in prepubertal children with CF. The observed dimensional changes of the muscular, cardiovascular and pulmonary system seem to improve aerobic exercise capacity and respiratory and peripheral muscle strength. The physiological background of the observed changes is not yet fully understood, therefore, larger-scale studies with an optimised design are required.


Growth Hormone Cystic Fibrosis Lean Body Mass Exercise Tolerance Growth Hormone Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No sources of funding were used to assist in the preparation of this manuscript. The author has no conflicts of interest that are directly relevant to the content of this manuscript.


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Authors and Affiliations

  1. 1.Department of Physical Medicine and RehabilitationHaukeland University HospitalBergenNorway
  2. 2.Department of Biological Sciences, Centre for Sports and Exercise ScienceUniversity of EssexColchesterUK

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