Sports Medicine

, Volume 7, Issue 1, pp 1–17 | Cite as

The Effects of Exercise on Reproductive Function in Men

  • David C. Cumming
  • Garry D. Wheeler
  • Ewen M. McColl
Review Article

Summary

Physical activity has a range of effects on male reproductive function depending upon the intensity and duration of the activity and the fitness of the individual. In general, it appears that relatively short, intense exercise increases serum testosterone levels, but there is debate to what degree haemoconcentration, decreased clearance and/or increased synthesis are involved. It is clear from the promptness of the testosterone increment that the mechanism does not involve gonadotrophin stimulation of the testes.

There is suppression of serum testosterone levels during and subsequent to more prolonged exercise (and to some extent in the hours following intense short term exercise). Again the mechanisms are not clear: a variety of systems could influence the decrease of testosterone synthesis, including decreased gonadotrophin, increased cortisol, catecholamine or prolactin levels, or perhaps even an accumulation of metabolic waste materials.

Endurance training induces changes in the function of the reproductive axis in men in a manner which appears similar to the changes in women. As in women, there is a subclinical inhibition of normal reproductive function but it is unclear whether clinical expression of reproductive suppression is common in men.

The long term, physiological suppression of the hypothalamic-pituitary-gonadal axis in men is probably not of major significance but it is clear that further investigation in several areas is essential to provide continuing reassurance that ‘exercise is good for you’.

Keywords

Testosterone Luteinising Hormone Testosterone Level Endurance Training Free Testosterone 

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References

  1. Aakvaag A, Sand T, Opstad PK, Fonnum F. Hormonal changes in young men during prolonged physical strain. European Journal of Applied Physiology and Occupational Physiology 39: 283–291, 1978PubMedGoogle Scholar
  2. Adlercreutz H, Harkonen M, Kuopposalmi K, Naveri H, Huhtaniemi H, et al. Effect of training on plasma anabolic and catabolic steroid hormones and their responses during physical exercise. International Journal of Sports Medicine 7 (Suppl.): 27–28, 1986PubMedGoogle Scholar
  3. Alford FP, Baker HWG, Patel YC, Rennie GC, Youatt G, et al. Temporal patterns of circulating hormones as assessed by continuous blood sampling. Journal of Clinical Endocrinology and Metabolism 36: 108–116, 1973PubMedGoogle Scholar
  4. Aloia JF, Cohn SH, Babu T, Abesamic C, Kalici N, et al. Skeletal mass and body composition in marathon runners. Metabolism 27: 1793–1796, 1978PubMedGoogle Scholar
  5. Ayers JWT, Komesu Y, Romain T, Ansbacher RA. Anthropometric, hormonal and psychologic correlates of semen quality in endurance trained male athletes. Fertility and Sterility 43: 917–921, 1985PubMedGoogle Scholar
  6. Baird DT, Horton R, Longcope C, Tait JF. Steroid dynamics under steady state conditions. Recent Progress in Hormone Research 25: 611–624, 1969PubMedGoogle Scholar
  7. Baker ER, Leuker R, Stumpf PG. Relationship of exercise to semen parameters and fertility success of artificial insemination donors. Abstract. Fertility and Sterility 41: 107S, 1984Google Scholar
  8. Baker HWG, Santen RJ, Berger HG, de Kretser DM, Hudson B, et al. Rhythms in the secretion of gonadotropins and gonadal steroids. Journal of Steroid Biochemistry 6: 793–801, 1975PubMedGoogle Scholar
  9. Barron JL, Noakes TD, Levy W, Smith C, Millar RP. Hypothalamic dysfunction in overtrained athletes. Journal of Clinical Endocrinology and Metabolism 60: 803–806, 1985PubMedGoogle Scholar
  10. Berchtold P, Berger M, Cuppers HJ, Herrman J, Niesschlag E, et al. Non-regulatory hormones during physical exercise in juvenile type diabetics. Hormone and Metabolism Research 10: 269–273, 1978Google Scholar
  11. Blumenthal JA, O’Toole LC, Chang JL. Is running an analogue of anorexia nervosa? Journal of the American Medical Association 252: 520–523, 1984PubMedGoogle Scholar
  12. Boyar RM, Rosenfeld RS, Finkelstein JW, Kapen S, Rottwarg HP, et al. Ontogeny of luteinizing hormone and testosterone secretion. Journal of Steroid Biochemistry 6: 803–808, 1975PubMedGoogle Scholar
  13. Boyden TW, Pamenter RW, Stanforth P, Rotkis T, Wilmore JH. Sex steroids and distance running in women. Fertility and Sterility 39: 629–632, 1983PubMedGoogle Scholar
  14. Boyden TW, Pamenter RW, Stanforth PR, Rotkis TC, Wilmore JH. Impaired gonadotropin responses to gonadotropin releasing hormone stimulation in endurance trained women. Fertility and Sterility 41: 359–363, 1984PubMedGoogle Scholar
  15. Brisson GR, Volle MA, Desharnais M, Dion M, Tanaka M. Pituitary-gonadal axis in exercising man. Abstract. Medicine and Science in Sports and Exercise 9: 47, 1977Google Scholar
  16. Brooks SM, Sanborn CF, Albrecht BH, Wagner WW. Diet in athletic amenorrhea. Correspondence. Lancet 1: 559–560, 1984PubMedGoogle Scholar
  17. Burke CW, Anderson DC. Sex hormone binding globulin is an estrogen amplifier. Nature 240: 38–40, 1972PubMedGoogle Scholar
  18. Cadoux-Hudson TA, Few JD, Imms FJ. The effect of exercise on the production and clearance of testosterone in well trained young men. European Journal of Applied Physiology and Occupational Physiology 54: 321–325, 1985PubMedGoogle Scholar
  19. Cumming DC. The reproductive effects of exercise and training. Current Problems in Obstetrics, Gynecology and Fertility 10: 321–285, 1987Google Scholar
  20. Cumming DC, Brunsting LA III, Strich G, Ries AL, Rebar RW. Reproductive hormone increases in response to acute exercise in men. Medicine and Science in Sports and Exercise 18: 369–373, 1986PubMedGoogle Scholar
  21. Cumming DC, Quigley ME, Yeu SSC. Acute suppression of circulating testosterone levels by cortisol in man. Journal of Clinical Endocrinology and Metabolism 57: 671–673, 1983PubMedGoogle Scholar
  22. Cumming DC, Vickovic MM, Wall SR, Fluker MR. Defects in pulsatile LH release in normally menstruating runners. Journal of Clinical Endocrinology and Metabolism 60: 810–812, 1985aPubMedGoogle Scholar
  23. Cumming DC, Vickovic MM, Wall SR, Fluker MR, Beicastro AN. The effect of acute exercise on pulsatile release of luteinizing hormone in women runners. American Journal of Obstetrics and Gynecology 141: 482–485, 1985bGoogle Scholar
  24. Cumming DC, Wall SR, Quinney HA, Beicastro AN. Decrease in serum testosterone levels with maximal intensity swimming exercise in trained male and female swimmers. Endocrine Research 13: 31–41, 1987PubMedGoogle Scholar
  25. Cumming DC, Wheeler GD. Opiates in exercise physiology. Seminars in Reproductive Endocrinology 5: 171–179, 1987Google Scholar
  26. Dahlmann B, Widjaja A, Reinauer H. Antagonistic effect of endurance training and testosterone on alkaline proteolytic activity in rat skeletal muscles. European Journal of Applied Physiology and Occupational Physiology 46: 229–235, 1981PubMedGoogle Scholar
  27. de Lignieres B, Plas J-N, Commandre F, Morville R, Viani J-L, et al. Secretion testiculaire d’androgenes apres effort physique prolongue chez Phomme. Nouvelle Presse Medicale 5: 2060–2064, 1976PubMedGoogle Scholar
  28. Dessypris K, Kuoppasalmi K, Adlercreutz H. Plasma cortisol, testosterone, androstenedione and luteinizing hormone (LH) in a non-competitive marathon run. Journal of Steroid Biochemistry 7: 33–37, 1976PubMedGoogle Scholar
  29. Deuster PA, Kylem SB, Moser PB, Vigersky RA, Singh A, et al. Nutritional intakes and status of highly trained amenorrheic and eumenorrheic women runners. Fertility and Sterility 46: 636–643, 1986PubMedGoogle Scholar
  30. Dohm GL, Louis TM. Changes in androstenedione, testosterone and protein metabolism as a result of exercise. Proceeding of the Society for Experimental Biology and Medicine 158: 622–625, 1978Google Scholar
  31. Drinkwater BL, Nilson K, Chesnut CH III, Bremmer W, Shainholtz S, et al. Bone mineral content of amenorrheic and eumenorrheic athletes. New England Journal of Medicine 31: 277–281, 1984Google Scholar
  32. Drinkwater BL, Nilson K, Ott S, Chesnut CH III. Bone mineral density after resumption of menses in amenorrheic athletes. Journal of the American Medical Association 256: 380–382, 1986PubMedGoogle Scholar
  33. Editorial. Special survey: running and sex. The Runner (May): 26–35, 1982Google Scholar
  34. Elias AN, Pandian MR, Weathersbee P, Stone S, Tobis J. Beta-endorphin/beta-lipoprotein release and gonadotropin secretion after exercise in normal males. Journal of Applied Physiology 61: 2045–2049, 1986PubMedGoogle Scholar
  35. Eik-Nes KB. On the relationship between testicular blood flow and secretion of testosterone in anesthetized dogs stimulated with human chorionic gonadotropin. Canadian Journal of Physiology and Pharmacology 42: 671–677, 1964PubMedGoogle Scholar
  36. Ellison PT, Lager C. Exercise-induced menstrual disorders. Correspondence. New England Journal of Medicine 313: 825–826, 1985Google Scholar
  37. Enger S, Herbjornsen K, Erikssen D, Fretland A. High density lipoproteins and physical activity: the influence of physical exercise, age and smoking on HDL-cholesterol and the HDL/total cholesterol ratio. Scandinavian Journal of Clinical and Laboratory Investigation 37: 251–255, 1977PubMedGoogle Scholar
  38. Epling WF, Pierce WD, Stefan L. A theory of activity-based anorexia. International Journal of Eating Disorders 3: 27–46, 1983Google Scholar
  39. Fahey TD, Rolph R, Moongee P, Nagel J, Mortara S. Serum testosterone, body composition, and strength of young adults. Medicine and Science in Sports and Exercise 1: 31–34, 1976Google Scholar
  40. Foresta C, Ruzza G, Mioni R, Guarneri G, Gribaldo R, et al. Osteoporosis and decline of gonadal function in the elderly man. Hormone Research 19: 18–22, 1984PubMedGoogle Scholar
  41. Frey MAB, Doerr BM, Srivastava LM, Glueck CJ. Exercise training, sex hormones and lipoprotein relationships in men. Journal of Applied Physiology 54: 757–762, 1983PubMedGoogle Scholar
  42. Galbo H, Hummer L, Petersen LB, Christensen NJ, Bie N. Thyroid and testicular responses to graded and prolonged exercise in man. European Journal of Applied Physiology and Occupational Physiology 36: 101–106, 1977PubMedGoogle Scholar
  43. Gawel MJ, Park DM, Alaghband-Zadeh J, Rose FC. Exercise and hormonal secretion. Postgraduate Medical Journal 55: 373–376, 1979PubMedGoogle Scholar
  44. Goldberg RB, Rabin D, Alexander AN, Doelle GGC, Getz GS. Suppression of plasma testosterone leads to an increase in total and high density lipoprotein cholesterol and apoproteins A1 and B. Journal of Clinical Endocrinology and Metabolism 60: 203–207, 1985PubMedGoogle Scholar
  45. Hackney AC, Sinning WE, Bruot BC. Reproductive hormonal profiles of endurance-trained and untrained males. Medicine and Science in Sports and Exercise 2: 60–65, 1988Google Scholar
  46. Hakkinen K, Pakarinen A, Alen M, Kauhanen H, Komi PV. Relationships between training volume, physical performance capacity and serum hormone concentrations during prolonged weight training in elite weight lifters. International Journal of Sports Medicine 8 (Suppl.): 61–65, 1987PubMedGoogle Scholar
  47. Hamalainen EK, Adlercreutz H, Puska P, Pietinen P. Decrease of serum total and free testosterone during a low-fat high fibre diet. Journal of Steroid Biochemistry 18: 369–370, 1983PubMedGoogle Scholar
  48. Hartung GH, Foreyt JP, Mitchell RE, Vlasek I, Gotto AM. Relation of diet to high-density-lipoprotein cholesterol in middle aged marathon runners, joggers and inactive men. New England Journal of Medicine 302: 357–361, 1980PubMedGoogle Scholar
  49. Hill P, Wynder E, Garbacrewski L, Games H, Walker ARP, et al. Plasma hormones and lipids in men at different risk for coronary heart disease. American Journal of Clinical Nutrition 33: 1010–1018, 1980PubMedGoogle Scholar
  50. Jezova D, Vigas M. Testosterone response to exercise during blockade and stimulation of adrenergic receptors in man. Hormone Research 15: 141–147, 1981PubMedGoogle Scholar
  51. Jezova-Repcekova D, Vigas M, Mikulaj L, Jurcovicova J. Plasma testosterone during bicycle ergometer exercise without and after L-dopa pre-treatment. Endocrinologia Experimentalis 16: 3–8, 1982PubMedGoogle Scholar
  52. Johnson CC, Stone MH, Byrd RJ, Lopez-S A. The response of serum lipids and plasma androgens to weight training exercise in sedentary males. Journal of Sports Medicine and Physical Fitness 23: 39–44, 1983PubMedGoogle Scholar
  53. Johnson MH, Everitt BJ. Essential reproduction, 3rd ed., Oxford, Blackwell Scientific Publications, 1988Google Scholar
  54. Judd HL, Parker DC, Siler TM, Yen SSC. Elucidation of the nocturnal rise in testosterone in pubertal boys. Journal of Clinical Endocrinology and Metabolism 38: 710–713, 1974aPubMedGoogle Scholar
  55. Judd HL, Rebar R, Vandenberg G, Yen SSC Effect of luteinizing hormone releasing factor on Leydig cell function. Journal of Clinical Endocrinology and Metabolism 38: 8–13, 1974bPubMedGoogle Scholar
  56. Kantor MA, Cullinane EM, Herbert PN, Thompson PD. Acute increase in lipoprotein lipase following prolonged exercise. Metabolism 33: 454–457, 1984PubMedGoogle Scholar
  57. Keast D, Cameron K, Morton AR. Exercise and the immune response. Sports Medicine 5: 248–267, 1988PubMedGoogle Scholar
  58. Keizer HA, Doorfman J, Bunnik GSJ. Influence of physical exercise on sex hormone metabolism. Medicine and Science in Sports and Exercise 48: 765–769, 1982Google Scholar
  59. Kindermann W, Schmitt WM, Schnable A, Berg A, Biro G. Verhalten von Testosteron im Blutserum bei Koerparerbeit unterschiedlicher Dauer und Intensitaet. Deutsche Zeitschrift fuer Sportmedizin 36: 99–104, 1985Google Scholar
  60. Kindermann W, Schnable A, Schmitt WM, Biro G, Cassens J, et al. Catecholamines, growth hormone, cortisol, insulin and sex hormones in aerobic and anaerobic exercise. European Journal of Applied Physiology and Occupational Physiology 49: 389–399, 1982PubMedGoogle Scholar
  61. Kuopposalmi K. Plasma testosterone and sex-hormone-binding capacity in physical exercise. Scandinavian Journal of Clinical and Laboratory Investigation 40: 411–418, 1980Google Scholar
  62. Kuopposalmi K, Naveri H, Harkonen N, Adlerkreutz H. Plasma cortisol, a’dione, testosterone and luteinizing hormone in running exercise of various intensities. Scandinavian Journal of Clinical and Laboratory Investigation 40: 403–409, 1980Google Scholar
  63. Kuopposalmi K, Naveri H, Rehunen S, Harkonen M, Adlercreutz H. Effect of strenuous anaerobic running exercise on plasma growth hormone, cortisol, luteinizing hormone, testosterone, androstenedione, estrone and estradiol. Journal of Steroid Biochemistry 7: 823–829, 1976Google Scholar
  64. Kyung NH, Barkan A, Klibanski A, Badger TM, McArthur JW, et al. Effect of carbohydrate supplementation on reproductive hormones during fasting in men. Journal of Clinical Endocrinology and Metabolism 60: 827–835, 1985PubMedGoogle Scholar
  65. Lamb DR. Androgens and exercise. Medicine and Science in Sports and Exercise 7: 1–5, 1975Google Scholar
  66. Levin J, Lloyd CW, Lobotsky J, Friedrich EH. The effect of epinephrine on testosterone production. Acta Endocrinologica 55: 184–192, 1967PubMedGoogle Scholar
  67. Lloyd T, Buchanan JR, Bitzer S, Waldman CJ, Myers C, Ford BG. Interrelationships of diet, athletic activity, menstrual status and bone density among collegiate women. American Journal of Clinical Nutrition 46: 681–684, 1987PubMedGoogle Scholar
  68. MacConnie SE, Barkan A, Lampman RM, Schork MA, Beitins IZ. Decreased hypothalamic gonadotropin releasing hormone secretion in male marathon runners. New England Journal of Medicine 315: 411–417, 1986PubMedGoogle Scholar
  69. Marshall JC, Anderson DC, Fraser TR, Harsoulis P. Human luteinizing hormone in man: studies of metabolism and biological action. Journal of Endocrinology 56: 431–439, 1973PubMedGoogle Scholar
  70. Mathur DN, Toriola AL, Dada OA. Serum cortisol and testosterone levels in conditioned male distance runners and non-athletes after maximal exercise. Journal of Sports Medicine and Physical Fitness 26: 245–250, 1986PubMedGoogle Scholar
  71. McConnell TR, Sinning WE. Exercise and temperature effects on human sperm production and testosterone levels. Medicine and Science in Sports and Exercise 16: 51–55, 1984PubMedGoogle Scholar
  72. Metivier G, Gauthier R, de la Chevotriere J, Grymala D. The effect of acute exercise on the serum levels of testosterone and luteinizing (LH) hormone in human male athletes. Journal of Sports Medicine and Physical Fitness 20: 235–237, 1980PubMedGoogle Scholar
  73. Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocrine Reviews 8: 1–28, 1987PubMedGoogle Scholar
  74. Morville R, Pesquies PC, Guezzenec CY, Serrurier BD, Guignard M. Plasma variations in testicular and adrenal androgens during prolonged physical exercise in man. Annales d’Endocrinologie (Paris) 40: 501–510, 1979Google Scholar
  75. Naftolin F, Judd HL, Yen SSC. Pulsatile patterns of gonadotropins in man: the effect of clomiphene with and without testosterone. Journal of Clinical Endocrinology and Metabolism 36: 285–288, 1973PubMedGoogle Scholar
  76. Naftolin F, Yen SSC, Tsai CC. Rapid cycling of plasma gonadotropins in normal men as demonstrated by frequent sampling. New Biology 236: 92–93, 1972PubMedGoogle Scholar
  77. Pardridge WM. Transport of protein bound hormones into tissues in vivo. Endocrine Reviews 2: 103–123, 1981PubMedGoogle Scholar
  78. Peltonen P, Marniemi J, Hietanen E, Vuori I, Enholm C. Changes in serum lipids, lipoproteins and heparin releasable lipolytic enzymes during moderate physical training in man: a longitudinal study. Metabolism 30: 518–526, 1981PubMedGoogle Scholar
  79. Remes K, Kuopposalmi K, Adlercreutz H. Effects of long term physical training on plasma testosterone, androstenedrone, luteinizing hormone, sex hormone binding capacity. Scandinavian Journal of Clinical and Laboratory Investigation 39: 743–749, 1979PubMedGoogle Scholar
  80. Riggs BL. Exercise, hypogonadism and osteopenia. Journal of the American Medical Association 256: 392–393, 1986PubMedGoogle Scholar
  81. Rigotti NA, Neer RM, Jameson L. Osteopenia and bone fractures in a man with anorexia nervosa and hypogonadism. Journal of the American Medical Association 256: 385–388, 1986PubMedGoogle Scholar
  82. Rogol AD, Veldhuis JD, Williams FA, Johnson ML. Pulsatile secretion of gonadotropins and prolactin in male marathon runners: relation to the endogenous opiate system. Journal of Andrology 5: 21–27, 1984PubMedGoogle Scholar
  83. Roth JC, Grumbach MM, Kaplan SL. Effect of synthetic luteinizing factor on serum testosterone and gonadotropins in prepubertal, pubertal and adult males. Journal of Clinical Endocrinology and Metabolism 37: 680–686, 1973PubMedGoogle Scholar
  84. Rowell LB. Human cardiovascular adjustments to exercise and thermal stress. Physiological Reviews 53: 75–159, 1974Google Scholar
  85. Rubin RT, Poland RE, Sobel I, Tower BB, Odell WD. Effects of prolactin and prolactin plus luteinizing hormone on plasma testosterone levels in normal adult men. Journal of Clinical Endocrinology and Metabolism 47: 447–452, 1978PubMedGoogle Scholar
  86. Schmid P, Pusch PP, Wolf WW, Pilger E, Pessenhofer H, et al. Serum FSH, LH and testosterone in humans after physical exercise. International Journal of Sports Medicine 3: 84–89, 1982PubMedGoogle Scholar
  87. Schurmeyer T, Jung K, Nieschlag E. The effects of an 1100 kilometer run on testicular adrenal and thyroid hormones. International Journal of Andrology 7: 276–282, 1984PubMedGoogle Scholar
  88. Schriewer H, Jung K, Gunnewiig V, Assmann G. Serum lipids and lipoproteins during a twenty day run of 1,100 kilometers. Annals of Sports Medicine 1: 71–74, 1983Google Scholar
  89. Schwartz B, Cumming DC, Riordan E, Selye M, Yen SSC, et al. Exercise associated amenorrhea: a distinct entity? American Journal of Obstetrics and Gynecology 141: 662–670, 1981PubMedGoogle Scholar
  90. Schweiger UF, Herman R, Laessle W, Riedel M, Schweiger M, et al. Caloric intake, stress and menstrual function in athletes. Fertility and Sterility 49: 447–450, 1988PubMedGoogle Scholar
  91. Snochowski M, Saartik T, Dahlberg E, Eriksson E, Gustafsson JA. Androgen and glucocorticoid receptors in human skeletal cytosol. Journal of Steroid Biochemistry 14: 765–771, 1981PubMedGoogle Scholar
  92. Stanish W. Overuse injuries in athletes: a perspective. Medicine and Science in Sports and Exercise 16: 1–7, 1984PubMedGoogle Scholar
  93. Stenstad P, Eik-Nes KB. Androgen metabolism in rat skeletal muscle in vitro. Biochemica Biophysica Acta 63: 169–176, 1981Google Scholar
  94. Strauss RH, Lanese RR, Malarkey WB. Weight loss in amateur wrestlers and its effect on testosterone levels. Journal of the American Medical Association 254: 3337–3338, 1985PubMedGoogle Scholar
  95. Sutton JR, Coleman MJ, Casey J, Lazarus L. Androgen responses during physical exercise. British Medical Journal 1: 520–522, 1973PubMedGoogle Scholar
  96. Sutton JR, Coleman MJ, Casey JH. Adrenocortical contribution to serum androgens during physical exercise. Abstract. Medicine and Science in Sports and Exercise 6: 72, 1974Google Scholar
  97. Sutton JR, Coleman MJ, Casey JH. Testosterone production rate during exercise. In Landry & Orban (Eds) 3rd International Symposium on Biochemistry of Exercise, pp. 227–234, Symposium Specialists, Miami, 1978Google Scholar
  98. Tanaka H, Cleroux J, de Champlain J, Ducharme JR, Collu R. Persistent effects of a marathon run on the pituitary-testicular axis. Journal of Endocrinological Investigation 9: 97–101, 1986PubMedGoogle Scholar
  99. Urhausen A, Kindermann W. Behaviour of testosterone, sex hormone binding globulin (SHBG) and cortisol before and after a triathlon. International Journal of Sports Medicine 8: 305–308, 1987PubMedGoogle Scholar
  100. Veldhuis JD, Evans WS, Demers LM, Thorner MO, Wakat D, et al. Altered neuroendocrine regulation of gonadotropin secretion in women distance runners. Journal of Clinical Endocrinology and Metabolism 61: 557–563, 1985PubMedGoogle Scholar
  101. Vermeulen A, Verdonck L, Van Der Straeten M, Orie N. Capacity of testosterone binding globulin in human plasma and its influence on specific binding of testosterone and its clearance rate. Journal of Clinical Endocrinology and Metabolism 29: 1470–1480, 1969Google Scholar
  102. Vogel RB, Books CA, Ketchum C, Zauner CW, Murray FT. Increase of free and total testosterone during submaximal exercise in normal males. Medicine and Science in Sports and Exercise 17: 119–123, 1984Google Scholar
  103. Wahren J, Felig P, Ahlborg G, Jorfeldt I. Glucose metabolism during leg exercise in man. Journal of Clinical Investigation 50: 2715–2725, 1971PubMedGoogle Scholar
  104. Wang C, Chan V, Tse TF, Yeung RTT. Effect of acute myocardial infarction on pituitary-testicular function. Clinical Endocrinology 9: 249–253, 1978aPubMedGoogle Scholar
  105. Wang C, Chan V, Yeung RTT. Effect of surgical stress on pituitary-testicular function. Clinical Endocrinology 9: 255–256, 1978bPubMedGoogle Scholar
  106. Warren MP. Effects of undernutrition on reproductive function in the human. Endocrine Reviews 4: 363–377, 1983PubMedGoogle Scholar
  107. Webb ML, Wallace JP, Hamill C, Hodgson JL, Mashaly MM. Serum testosterone concentration during two hours of moderate intensity treadmill running in trained men and women. Endocrine Research 10: 27–38, 1984PubMedGoogle Scholar
  108. Wheeler GD, Wall SR, Beicastro AN, Cumming DC. Reduced serum testosterone and prolactin levels in male distance runners. Journal of the American Medical Association 252: 514–516, 1984PubMedGoogle Scholar
  109. Wheeler GD, Wall SR, Beicastro AN, Conger P, Cumming DC. Are anorexic tendencies prevalent in the habitual runner? British Journal of Sports Medicine 20: 77–81, 1986PubMedGoogle Scholar
  110. Wheeler GD, Williamson S, Singh M, Pierce WD, Epling WF. Decreased serum total and free testosterone and LH pulse frequency with endurance training in men. Endocrine Society Annual Meeting, Abstract No. 767, 1987Google Scholar
  111. Wilkerson JE, Horvath SM, Gutin B. Plasma testosterone during treadmill exercise. Journal of Applied Physiology 49: 249–253, 1980PubMedGoogle Scholar
  112. Yates A, Leehay K, Shisslak CM. Running: an analogue of anorexia? New England Journal of Medicine 308: 251–255, 1983PubMedGoogle Scholar
  113. Zubiran S, Gomez-Mont F. Endocrine disturbance in chronic human malnutrition. Vitamins and Hormones 11: 97–102, 1952Google Scholar

Copyright information

© ADIS Press Limited 1989

Authors and Affiliations

  • David C. Cumming
    • 1
  • Garry D. Wheeler
    • 1
  • Ewen M. McColl
    • 1
  1. 1.Departments of Obstetrics and Gynaecology, Medicine (Division of Endocrinology), and Sports SciencesUniversity of AlbertaEdmontonCanada

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