Sports Medicine

, Volume 6, Issue 1, pp 23–28 | Cite as

Muscle Lipolysis During Exercise

An Update
  • Lawrence B. Oscai
  • Warren K. Palmer
Leading Article
  • 9 Downloads

Keywords

Lipase Lipase Activity Lipoprotein Lipase Lipoprotein Lipase Activity Triglyceride Lipase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bagby GJ, Johnson JL, Bennett BW, Shepherd RE. Muscle lipoprotein lipase activity in voluntary exercising Rats. Journal of Applied Physiology 60: 1623–1627, 1986PubMedGoogle Scholar
  2. Bagby GJ, Martinez RR. Expression of lipoprotein lipase activity in muscle. Abstract. Medicine and Science in Sports and Exercise (Suppl.): 19, 1987Google Scholar
  3. Barclay JK, Stainsby WN. Intramuscular lipid store utilization By contracting dog skeletal muscle in situ. American Journal of Physiology 223: 115–119, 1972PubMedGoogle Scholar
  4. Borensztajn J. Lipoprotein lipase. In Scanu et al. (Eds) The Biochemistry of atherosclerosis, pp. 231–245, Marcel Dekker, Inc., New York, 1979Google Scholar
  5. Borenzstajn J. Heart and skeletal muscle lipoprotein lipase. In Borenzstajn (Ed.) Lipoprotein Lipase, pp. 133–148, Evener Publishers Inc., Chicago, 1987Google Scholar
  6. Borensztajn J, Keig P, and Rubenstein AH. The Role of Glucagon in the Regulation of myocardial lipoprotein lipase activity. Biochemical and Biophysical Research Communications 53: 603–608, 1973PubMedCrossRefGoogle Scholar
  7. Borensztajn J, Rone MS, Babirak SP, McGarr JA, Oscai LB. Effect of exercise on lipoprotein lipase activity in Rat heart and skeletal muscle. American Journal of Physiology 229: 394–397, 1975PubMedGoogle Scholar
  8. Carlson LA, Ekelund L-G, Fröberg SO. Concentration of triglycerides, phospholipids and Glycogen in skeletal muscle and of free fatty acids and B-hydroxybutyric acid in Blood in man in Response to exercise. European Journal of Clinical Investigation 1: 248–254, 1971Google Scholar
  9. Darnell J, Lodish H, Baltimore D. Molecular Biology, p. 945, Scientific American Books, Inc., New York, 1986Google Scholar
  10. Fröberg SO. Effects of training and of acute exercise in trained Rats. Metabolism 20: 1044–1051, 1971PubMedCrossRefGoogle Scholar
  11. Gartner SL, Vahouny GV. Effects of epinephrine and cyclic 3′, 5′-AMP on perfused Rat hearts. American Journal of Physiology 222: 1121–1124, 1972PubMedGoogle Scholar
  12. Goldberg DI, Khoo JC. Activation of myocardial neutral triglyceride lipase and neutral cholesterol esterase By cAMP-dependent protein kinase. Journal of Biological Chemistry 260: 5879–5882, 1985PubMedGoogle Scholar
  13. Goldberg DI, Rumsey WL, Kendrick ZV. Exercise activation of myocardial lipoprotein lipase in male and estrogen-treated female Rats. Metabolism 33: 964–969, 1984PubMedCrossRefGoogle Scholar
  14. Havel RJ, Carlson LA, Ekelund L-G, Holmgren A. Turnover Rate and oxidation of different free fatty acids in man during exercise. Journal of Applied Physiology 19: 613–618, 1964PubMedGoogle Scholar
  15. Heathers GP, Al-Mohtaseb N, Brunt RV. The effect of adrenergic agents on the activities of Glycerol 3-phosphate acyltransferase and triglyceride lipase in the isolated perfused Rat heart. Journal of Molecular and Cellular Cardiology 17: 785–796, 1985PubMedCrossRefGoogle Scholar
  16. Holloszy JO, Winder WW, Fitts RH, Rennie MJ, Hickson RC, et al. Energy production during exercise. In Landry & Orban (Eds) Regulatory mechanisms in metabolism during exercise, pp. 61–74, Symposia Specialists, Miami, 1978Google Scholar
  17. Issekutz B, Paul P. Intramuscular energy sources in pancreatectomized dogs. American Journal of Physiology 215: 197–204, 1968PubMedGoogle Scholar
  18. Joh T, Nomiyama H, Maeda S, Shimada K, Morino Y. Cloning and sequence analysis of a cDNA encoding porcine mitochondrial aspartate aminotransferase precursor. Proceedings of the National Academy of Sciences 82: 6065–6069, 1985Google Scholar
  19. Lech JJ, Jesmok GJ, Calvert DN. Effects of drugs and hormones on lipoiysis in heart. Federation Proceedings 36: 2000–2008, 1977PubMedGoogle Scholar
  20. Lithell H, Lindgärde F, Hellsing K, Lundqvist G, Nygaard E, et al. Body Weight, skeletal muscle morphology, and enzyme activities in Relation to fasting serum insulin concentration and Glucose tolerance in 48-year-old men. Diabetes 30: 19–25, 1981PubMedCrossRefGoogle Scholar
  21. Miller WC, Oscai LB. Relationship Between type L hormone-sensitive lipase and endogenous triacylglycerols in Rat heart. American Journal of Physiology 247: R621–R625, 1984PubMedGoogle Scholar
  22. Miller WC, Palmer WK, Arnall DA, Oscai LB. Effect of cholera toxin on triacylglycerol lipase activity and triacylglycerol content of Rat heart. Canadian Journal of Physiology and Pharmacology 65: 60–63, 1987PubMedCrossRefGoogle Scholar
  23. Miller WC, Palmer WK, Oscai LB. Relationship Between type-L hormone-sensitive lipase activity and endogenous triacylglycerol in the hearts of colchicine-treated Rats. Biochemical Journal 224: 793–798, 1984PubMedGoogle Scholar
  24. Neely JR, Morgan HE. Relationship Between carbohydrate and lipid metabolism and the energy Balance of heart muscle. Annual Review of Physiology 36: 413–459, 1974PubMedCrossRefGoogle Scholar
  25. Neely JR, Rovetto MJ, Oram JF. Myocardial utilization of carbohydrates and lipids. Progress in Cardiovascular Diseases 15: 289–329, 1972Google Scholar
  26. Nikkilä EA. Role of lipoprotein lipase in metabolic adaptation to exercise and training. In Borensztajn (Ed.) Lipoprotein lipase, pp. 187–199, Evener, Chicago, 1987Google Scholar
  27. Nikkilä EA, Taskinen M-R, Rehunen S, Härkönen M. Lipoprotein lipase activity in adipose tissue and skeletal muscle of Runners: Relation to serum lipoproteins. Metabolism 27: 1661–1671, 1978PubMedCrossRefGoogle Scholar
  28. Nikkilä EA, Torsti P, Penttilä P. The effect of exercise on lipoprotein lipase activity of Rat heart, adipose tissue and skeletal muscle. Metabolism 12: 863–865, 1963Google Scholar
  29. Nilsson-Ehle P. Measurements of lipoprotein lipase activity. In Borensztajn (Ed.) Lipoprotein lipase, pp. 59–77, Evener, Chicago, 1987Google Scholar
  30. Obaru K, Nomiyama H, Shimada K, Nagashima F, Morino Y. Cloning and sequence analysis of mRNA for mouse aspartate aminotransferase isoenzymes. Journal of Biological Chemistry 261: 16976–16983, 1986PubMedGoogle Scholar
  31. Oscai LB. Role of lipoprotein lipase in Regulating endogenous triacylglycerols in Rat heart. Biochemical and Biophysical Research Communications 91: 227–232, 1979PubMedCrossRefGoogle Scholar
  32. Oscai LB, Caruso RA, Wergeies AC. Lipoprotein lipase hydrolyzes endogenous triacylglycerols in muscle of exercised Rats. Journal of Applied Physiology 52: 1059–1063, 1982PubMedGoogle Scholar
  33. Palmer WK, Caruso RA, Oscai LB. Possible Role of lipoprotein lipase in the Regulation of endogenous triacylglycerols in the Rat heart. Biochemical Journal 198: 159–166, 1981PubMedGoogle Scholar
  34. Palmer WK, Caruso RA, Oscai LB. Cyclic AMP activation of a triglyceride lipase in Broken cell preparations of Rat heart. Archives of Biochemistry and Biophysics 249: 255–262, 1986PubMedCrossRefGoogle Scholar
  35. Palmer WK, Caruso RA, Oscai LB. Protein kinase inhibitor Blocks the activation of a myocardial triacylglycerol lipase. Journal of Molecular and Cellular Cardiology 19: 653–659, 1987PubMedCrossRefGoogle Scholar
  36. Palmer WK, Kane TA. Hormonal activation of type-L hormone-sensitive lipase measured in defatted heart powders. Biochemical Journal 212: 379–383, 1983aPubMedGoogle Scholar
  37. Palmer WK, Kane TA. Hormone-stimulated lipolysis in cardiac myocytes. Biochemical Journal 216: 241–243, 1983bPubMedGoogle Scholar
  38. Pernow B, Saltin B. Availability of substrates and capacity for prolonged heavy exercise in man. Journal of Applied Physiology 31: 416–422, 1971PubMedGoogle Scholar
  39. Reitman J, Baldwin KM, Holloszy JO. Intramuscular triglyceride utilization By Red, white, and intermediate skeletal muscle and heart during exhausting exercise. Proceedings of the Society for Experimental Biology and Medicine 142: 628–631, 1973Google Scholar
  40. Rennie MJ, Holloszy JO. Inhibition of Glucose uptake and Glycogenosis By availability of oleate in Well-oxygenated perfused skeletal muscle. Biochemical Journal 168: 161–170, 1977PubMedGoogle Scholar
  41. Robinson DS. The function of the plasma triglycerides in fatty acid transport. In Florkin & Stotz (Ed.) Comprehensive Biochemistry, Vol. 18, pp. 51–116, Elsevier Publishing Co., Amsterdam, 1970Google Scholar
  42. Rösen P, Budde T, Reinauer H. Triglyceride lipase activity in the diabetic Rat heart. Journal of Molecular and Cellular Cardiology 13: 539–550, 1981PubMedCrossRefGoogle Scholar
  43. Safer B. The metabolic significance of the malate-aspartate cycle in heart. Circulation Research 37: 527–533, 1975PubMedCrossRefGoogle Scholar
  44. Severson DL. Regulation of lipid metabolism in adipose tissue and heart. Canadian Journal of Physiology and Pharmacology 57: 923–937, 1979aPubMedCrossRefGoogle Scholar
  45. Severson DL. Characterization of triglyceride lipase activities in Rat heart. Journal of Molecular and Cellular Cardiology 11: 569–583, 1979bPubMedCrossRefGoogle Scholar
  46. Terjung RL, Budohoski L, Nazar K, Kobryn A, Kaciuba-Uscilko H. Chylomicron triglyceride metabolism in Resting and exercising fed dogs. Journal of Applied Physiology 52: 815–820, 1982PubMedGoogle Scholar
  47. Terjung RL, Mackie BG, Dudley GA, Kaciuba-Uscilko H. Influence of exercise on chylomicron triacylglycerol metabolism: plasma turnover and muscle uptake. Medicine and Science in Sports and Exercise 15: 340–347, 1983PubMedGoogle Scholar
  48. Williamson JR. Metabolic effects of epinephrine in the isolated, perfused Rat heart. I. Dissociation of the Glycogenolytic from the metabolic stimulatory effect. Journal of Biological Chemistry 239: 2721–2729, 1964PubMedGoogle Scholar
  49. Wion KL, Kirchgessner TG, Lusis AJ, Schotz MC, Lawn RM. Human lipoprotein lipase complementary DNA sequence. Science 235: 1638–1641, 1987PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press Limited 1988

Authors and Affiliations

  • Lawrence B. Oscai
    • 1
  • Warren K. Palmer
    • 1
  1. 1.Exercise Research Division, Department of Physical EducationUniversity of Illinois at ChicagoChicagoUSA

Personalised recommendations