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Improving Delivery of Aminosalicylates in Ulcerative Colitis

Effect on Patient Outcomes

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Abstract

Developments in drug delivery technology have expanded the formulations of 5-aminosalicylic acid (5-ASA) available to clinicians over the last 50 years. Delivery of adequate doses of 5-ASA to the colon can be achieved by pH-dependent, delayed-release or pro-drug formulations. Despite some variations in the pharmacokinetics between individual preparations, the clinical effects in induction of response and maintenance of remission in ulcerative colitis appear to be consistent. Direct comparison studies between different preparations haveyielded similar results in primary endpoints, although differences in secondary endpoints or post hoc analyses have been noted. The development of delivery methods that allow once-daily administration represents a potential means to improve the low medication adherence rates reported in patients with ulcerative colitis.

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Notes

  1. The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgements

No sources of funding were used to assist in the preparation of this review. Dr Moss has received grant support from Protor & Gamble. Dr Fernandez-Becker has no conflicts of interest that are directly relevant to the content of this review.

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  1. Center for Inflammatory Bowel Disease, Division of Gastroenterology, Rabb/Rose 1, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts, 02215, USA

    Nielsen Q. Fernandez-Becker &  Alan C. Moss

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Fernandez-Becker, N.Q., Moss, A.C. Improving Delivery of Aminosalicylates in Ulcerative Colitis. Drugs 68, 1089–1103 (2008). https://doi.org/10.2165/00003495-200868080-00006

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