Drugs

, Volume 68, Issue 6, pp 803–838 | Cite as

Meropenem

A Review of its Use in the Treatment of Serious Bacterial Infections
  • Claudine M. Baldwin
  • Katherine A. Lyseng-Williamson
  • Susan J. Keam
Adis Drug Evaluation

Summary

Abstract

Meropenem (Merrem®, Meronem®) is a broad-spectrum antibacterial agent of the carbapenem family, indicated as empirical therapy prior to the identification of causative organisms, or for disease caused by single or multiple susceptible bacteria in both adults and children with a broad range of serious infections.

Meropenem is approved for use in complicated intra-abdominal infection (cIAI), complicated skin and skin structure infection (cSSSI) and bacterial meningitis (in paediatric patients aged ≥3 months) in the US, and in most other countries for nosocomial pneumonia, cIAI, septicaemia, febrile neutropenia, cSSSI, bacterial meningitis, complicated urinary tract infection (UTI), obstetric and gynaecological infections, in cystic fibrosis patients with pulmonary exacerbations, and for the treatment of severe community-acquired pneumonia (CAP).

Meropenem has a broad spectrum of in vitro activity against Gram-positive and Gram-negative pathogens, including extended-spectrum β-lactamase (ESBL)-and AmpC-producing Enterobacteriaceae. It has similar efficacy to comparator antibacterial agents, including: imipenem/cilastatin in cIAI, cSSSI, febrile neutropenia, complicated UTI, obstetric or gynaecological infections and severe CAP; clindamycin plus tobramycin or gentamicin in cIAI or obstetric/ gynaecological infections; cefotaxime plus metronidazole in cIAI; cefepime and ceftazidime plus amikacin in septicaemia or febrile neutropenia; and ceftazidime, clarithromycin plus ceftriaxone or amikacin in severe CAP. Meropenem has also shown similar efficacy to cefotaxime in paediatric and adult patients with bacterial meningitis, and to ceftazidime when both agents were administered with or without tobramycin in patients with cystic fibrosis experiencing acute pulmonary exacerbations. Meropenem showed greater efficacy than ceftazidime or piperacillin/tazobactam in febrile neutropenia, and greater efficacy than ceftazidime plus amikacin or tobramycin in patients with nosocomial pneumonia. Meropenem is well tolerated and has the advantage of being suitable for administration as an intravenous bolus or infusion. Its low propensity for inducing seizures means that it is suitable for treating bacterial meningitis and is the only carbapenem approved in this indication. Thus, meropenem continues to be an important option for the empirical treatment of serious bacterial infections in hospitalized patients.

Pharmacological Properties

Meropenem demonstrated good in vitro activity against clinically relevant Enterobacteriaceae (Citrobacter freundii, C. koseri, Enterobacter aerogenes, E. cloaceae, Escherichia coli, Klebsiella pneumoniae, K. oxytoca, Morganella morganii, Proteus mirabilis, P. vulgaris and Serratia marcescens). The minimum concentration inhibiting 90% of strains (MIC90) was ≤0.25 mg/L and susceptibility rates were 98–100%. Meropenem was active against ESBL-and AmpC-producing Enterobacteriaceae, with little or no change in MIC90 values compared with non-ESBL-and non-AmpC-producing strains. Meropenem also demonstrated good activity against Haemophilus influenzae and Neisseria meningitidis (MIC90 0.25 mg/L; susceptibility rates of 99–100%). Against Pseudomonas aeruginosa, Acinetobacter baumannii and Burkholderia cepacia, MIC90 values were 16–64 mg/L and susceptibility rates were 71.5–76.4%. Meropenem demonstrated good in vitro activity against Gram-positive pathogens, including Staphylococcus aureus (methicillin/oxacillin-susceptible isolates), S. epidermidis (oxacillin-susceptible isolates), Streptococcus pneumoniae (including penicillin-resistant strains) and viridans group streptococci (MIC90 of 0.25–2 mg/L; susceptibility rates of 95–100%), but had poor activity against Enterococcus faecalis. Meropenem lacked activity against methicillin/oxacillin-resistant staphylococci and E. faecium. Meropenem demonstrated good in vitro activity against a range of anaerobes, including Clostridium difficile, C. perfringens, and Peptostreptococcus spp. and Prevotella spp. (MIC90 0.125–4 mg/L; susceptibility rates 100%). Against Bacteroides fragilis, meropenem had an MIC90 of 8 mg/L with a susceptibility rate of 89%.

A mathematical model has estimated that meropenem is likely to achieve an optimal bactericidal pharmacodynamic target attainment against E. coli and K. pneumoniae, but a lower attainment against P. aeruginosa and A. baumannii. Meropenem is also estimated to achieve an optimal bactericidal pharmacodynamic target attainment against most pathogens associated with nosocomial pneumonia, cIAI, nosocomial blood infection, cSSSI and paediatric meningitis.

Meropenem has rapid, time-dependent bactericidal activity and a minimal inoculum effect. Meropenem shows stability against hydrolysis by most β-lactamases, including ESBLs and AmpC β-lactamases, but may be affected by carbapenemases such as metallo-β-lactamases, serine carbapenemases and oxacil-linases with carbapenemase activity (such as OXA-23, OXA-24 and OXA-58). Except for the production of carbapenemases, it appears that two or more resistance mechanisms, such as reduced permeability or overexpression of multidrug efflux pumps, are required for significant carbapenem resistance to emerge. Meropenem appears to have a low potential for selecting resistant strains in vitro.

Meropenem did not accumulate at steady state after intravenous administration. Plasma protein binding is low (≈2%) and meropenem achieves good penetration into a wide range of tissues, including lung, skin blister fluid, interstitial fluid, intra-abdominal tissues, peritoneal fluid and cerebrospinal fluid. Meropenem is mainly eliminated via the kidneys and clinically significant alterations to the pharmacokinetics of the drug are seen in patients with advanced or end-stage renal failure. Meropenem has a short plasma elimination half-life of ≈1 hour.

Clinical Efficacy

The efficacy of meropenem in adult and paediatric patients with serious bacterial infections has been examined in numerous well designed trials.

Meropenem showed greater efficacy than the combinations of ceftazidime plus amikacin or tobramycin in patients with nosocomial pneumonia, with end of treatment (EOT) clinical response rates of 83% and 89% vs 66% and 72%, and bacteriological response rates of 75% and 89% vs 53% and 67%.

Meropenem was as effective as imipenem/cilastatin in four trials in patients with cIAI, with clinical cure rates at EOT or follow-up of 90–98% and 88–98% for the respective treatments, and bacteriological cure rates of 84–98% and 79–96%. In one trial, clinical cure rates were 84% and 85% with meropenem or doripenem, and the respective bacteriological cure rates were 85% and 84%. In a comparison between meropenem and tobramycin plus clindamycin, clinical and bacteriological response rates were each 96% with meropenem and 93% with tobramycin plus clindamycin. In two trials comparing the efficacy of meropenem and cefotaxime plus metronidazole, results were mixed.

In patients with septicaemiae secondary to a serious bacterial infection, meropenem was as effective as ceftazidime with or without amikacin, with clinical response rates at EOT of 92% and 94% for the respective treatments.

Meropenem was as effective as imipenem/cilastatin, cefepime, ceftazidime with or without amikacin or piperacillin/tazobactam in numerous trials in patients with febrile neutropenia, with initial response rates to unmodified treatment regimens at 72 hours of 56–88% and 40–80% of episodes. Response rates to meropenem were significantly greater than ceftazidime (56% vs 40%; p = 0.003) and piperacillin/tazobactam (64% vs 50%; p < 0.05). Treatment success at EOT, regardless of regimen modification, was seen in 44–100% of episodes treated with meropenem and 41–100% of those treated with comparators; meropenem was more effective than ceftazidime in one trial (54% vs 44%; p < 0.05).

Meropenem efficacy was noninferior to that of imipenem/cilastatin in patients with cSSSI in one trial, with clinical response rates of 86% and 83%, respectively, at the follow-up visit. In another trial, there were no significant differences between meropenem and imipenem/cilastatin in terms of clinical response (98% vs 95%) or bacteriological response (94% vs 91%) at EOT assessment.

The proportion of patients achieving cure with no sequelae with meropenem in two trials in paediatric patients with bacterial meningitis did not differ from that with cefotaxime at EOT (46% vs 56%) and/or follow-up (54% vs 58% and 72% vs 81%). In adult patients with meningitis, clinical cure (with or without sequelae) occurred in 100% of clinically evaluable meropenem recipients compared with 77% of cephalosporin (cefotaxime or ceftriaxone) recipients.

Meropenem was an effective alternative therapy to imipenem/cilastatin in patients with complicated UTI, evidenced by clinical responses of 99% in either treatment group and bacteriological responses in 90% of meropenem and 87% of imipenem/cilastatin recipients.

In women with obstetric or gynaecological infections, meropenem achieved similar clinical or bacteriological response rates at EOT and follow-up to clindamycin plus gentamycin (88–98% vs 86–100%). In another trial, meropenem achieved a significantly higher clinical cure rate than imipenem/cilastatin at EOT (100% vs 90%; p = 0.026), but not at follow-up (98% vs 97%).

In two trials in patients with cystic fibrosis, meropenem plus tobramycin improved pulmonary function at EOT in patients with acute exacerbations of infection to the same extent as ceftazidime plus tobramycin (absolute change from baseline in percentage predicted forced expiratory volume in one second of 5.1–13.8% and 6.1–11.1%), confirming results of an earlier trial of meropenem versus ceftazidime monotherapy in which 98% of meropenem and 90% of ceftazidime recipients were classed as responders. Both combination therapy regimens decreased sputum bacterial burden.

In patients with severe CAP, meropenem achieved clinical response rates of 87–91 % at EOT and 96–100% at follow-up, which were similar to those seen with imipenem/cilastatin (86–91% and 100%), ceftazidime (90% and not reported), clarithromycin plus ceftriaxone (69% and 92%) or clarithromycin plus amikacin (86% and 96%). Bacteriological response rates with meropenem, imipenem/cilastatin or ceftazidime at EOT or follow-up were 95–100%, 93% and 100%, and 92% for the respective treatments.

Pharmacoeconomic analyses of meropenem from a health payer perspective in the UK, US and Russia predicted that meropenem is a cost-effective therapy relative to other antibacterials, including imipenem/cilastatin or conventional combination antibacterial treatments in the treatment of serious bacterial infections in intensive care units. In the UK cost-utility analysis, meropenem dominated imipenem/cilastatin with regard to cost per quality-adjusted life-year gained, and was predicted to be more cost-effective than imipenem/cilastatin in the treatment of P. aeruginosa infections in the US and conventional combination antibacterial treatments in high-risk nosocomial infections in Russia.

Tolerability

Intravenous meropenem was generally well tolerated in adult and paediatric patients with serious bacterial infections, and most adverse events were mild to moderate in severity. The most commonly reported drug-related adverse events in patients treated with meropenem included diarrhoea, rash, and/or nausea and vomiting; in paediatric patients, diarrhoea and rash were most common. The most commonly reported laboratory adverse events included increased levels of ALT and AST and thrombocytosis. Meropenem had good CNS tolerability with an incidence of drug-related seizures in patients with infections other than meningitis of 0.07%. No seizures were considered to be related to meropenem in a trial in paediatric patients with bacterial meningitis.

Keywords

Cystic Fibrosis Febrile Neutropenia Ceftazidime Tobramycin Meropenem 

References

  1. 1.
    Kollef MH. Appropriate empirical antibacterial therapy for nosocomial infections: getting it right the first time. Drugs 2003; 63(20): 2157–68PubMedCrossRefGoogle Scholar
  2. 2.
    Zhanel GG, Wiebe R, Dilay L, et al. Comparative review of the carbapenems. Drugs 2007; 67(7): 1027–52PubMedCrossRefGoogle Scholar
  3. 3.
    Merrem/MeronemTM (IV, 500mg, 1g): core data sheet. Astra-Zeneca, 2006 SepGoogle Scholar
  4. 4.
    Hurst M, Lamb HM. Meropenem: a review of its use in patients in intensive care. Drugs 2000; 59(3): 653–80PubMedCrossRefGoogle Scholar
  5. 5.
    Lowe MN, Lamb HM. Meropenem: an updated review of its use in the management of intra-abdominal infections. Drugs 2000; 60: 619–46PubMedCrossRefGoogle Scholar
  6. 6.
    Wiseman LR, Wagstaff AJ, Brogden RN, et al. Meropenem: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs 1995; 50(1): 73–101PubMedCrossRefGoogle Scholar
  7. 7.
    Lamb HM, Goa KL. Management of febrile episodes in neutropenic patients: defining the role of meropenem. Dis Manage Health Outcomes 1999 Feb; 5: 101–15CrossRefGoogle Scholar
  8. 8.
    MerremRM IV (meropenem for injection): US Prescribing Information. AstraZeneca, 2007 FebGoogle Scholar
  9. 9.
    Electronic medicines compendium. Meronem IV 500mg & 1g, summary of product characteristics from the electronic medicines compendium [online]. Available from URL: http://www.emc.medicines.org.uk/ [Accessed 2008 Mar 17]
  10. 10.
    Jones RN, Mendes C, Turner PJ, et al. An overview of the Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program: 1997–2004. Diagn Microbiol Infect Dis 2005 Dec; 53(4): 247–56PubMedCrossRefGoogle Scholar
  11. 11.
    Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 18th informational supplement. 2008 JanGoogle Scholar
  12. 12.
    Clinical and Laboratory Standards Institute. Methods for antimicrobial susceptibility testing of anaerobic bacteria; approved standard —seventh edition. 2008 JanGoogle Scholar
  13. 13.
    Data on File. AstraZeneca, 2008Google Scholar
  14. 14.
    Jones RN, Sader HS, Fritsche TR. Comparative activity of doripenem and three other carbapenems tested against gram-negative bacilli with various beta-lactamase resistance mechanisms. Diagn Microbiol Infect Dis 2005; 52: 71–4PubMedCrossRefGoogle Scholar
  15. 15.
    Thomson KS, Moland ES. Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase producing enterobacteriaceae. Antimicrob Agents Chemother 2001; 45(12): 3548–54PubMedCrossRefGoogle Scholar
  16. 16.
    Gales AC, Jones RN, Sader HS. Global assessment of the antimicrobial activity of polymyxin B against 54 731 clinical isolates of gram-negative bacilli: report from the SENTRY antimicrobial surveillance programme (2001–2004). Clin Microbiol Infect 2006; 12(4): 315–21PubMedCrossRefGoogle Scholar
  17. 17.
    Jones RN, Sader HS, Beach ML. Contemporary in vitro spectrum of activity summary for antimicrobial agents tested against 18 569 strains of non-fermentative gram-negative bacilli isolated in the SENTRY antimicrobial surveillance program (1997–2001). Int J Antimicrob Agents 2003; 22(6): 551–6PubMedCrossRefGoogle Scholar
  18. 18.
    Sader HS, Jones RN. Antimicrobial susceptibility of uncommonly isolated non-enteric gram-negative bacilli. Int J Antimicrob Agents 2005; 25(2): 95–109PubMedCrossRefGoogle Scholar
  19. 19.
    Jones RN, Deshpande L, Fritsche TR, et al. Determination of epidemic clonality among multidrug-resistant strains of Acine-tobacter spp. and Pseudomonas aeruginosa in the MYSTIC Programme (USA, 1999–2003). Diagn Microbiol Infect Dis 2004 Jul; 49(3): 211–6PubMedCrossRefGoogle Scholar
  20. 20.
    Mutnick AH, Rhomberg PR, Sader HS, et al. Antimicrobial usage and resistance trend relationships from the MYSTIC Programme in North America (1999–2001). J Antimicrob Chemother 2004 Feb; 53(2): 290–6PubMedCrossRefGoogle Scholar
  21. 21.
    Turner PJ. Meropenem activity against European isolates: report on the MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) 2006 results. Diagn Microbiol Infect Dis 2008; 60: 185–92PubMedCrossRefGoogle Scholar
  22. 22.
    Rhomberg PR, Deshpande LM, Kirby JT, et al. Activity of meropenem as serine carbapenemases evolve in US medical centers: monitoring report from the MYSTIC Program (2006). Diagn Microbiol Infect Dis 2007 Jul 25Google Scholar
  23. 23.
    Deshpande LM, Rhomberg PR, Sader HS, et al. Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States Medical Centers: report from the MYSTIC Program (1999–2005). Diagn Microbiol Infect Dis 2006 Dec; 56(4): 367–72PubMedCrossRefGoogle Scholar
  24. 24.
    European Committee on Antimicrobial Susceptibility Testing. European Committee on Antimicrobial Susceptibility Testing guidelines [online]. Available from URL: http://www.escmid.org/ [Accessed 2008 Jan 1]
  25. 25.
    Jones RN, Huynh HK, Biedenbach DJ, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chem 2004; 54(1): 144–54CrossRefGoogle Scholar
  26. 26.
    Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing of anaerobic bacteria; informational supplement. 2003 JanGoogle Scholar
  27. 27.
    Pournaras S, Maniati M, Spanakis N, et al. Spread of efflux pump-overexpressing, non-metallo-beta-lactamase-producing, meropenem-resistant but ceftazidime-susceptible Pseudomonas aeruginosa in a region with blaVIM endemicity. J Antimicrob Chemother 2005 Oct; 56(4): 761–4PubMedCrossRefGoogle Scholar
  28. 28.
    El Amin N, Giske CG, Jalal S, et al. Carbapenem resistance mechanisms in Pseudomonas aeruginosa: alterations of porin OprD and efflux proteins do not fully explain resistance patterns observed in clinical isolates. APMIS 2005 Mar; 113(3): 187–96PubMedCrossRefGoogle Scholar
  29. 29.
    Kim SY, Park YJ, Yu JK, et al. Prevalence and mechanisms of decreased susceptibility to carbapenems in Klebsiella pneumoniae isolates. Diagn Microbiol Infect Dis 2007 Jan; 57(1): 85–91PubMedCrossRefGoogle Scholar
  30. 30.
    Ong CT, Tessier PR, Li C, et al. Comparative in vivo efficacy of meropenem, imipenem, and cefepime against Pseudomonas aeruginosa expressing MexA-MexB-OprM efflux pumps. Diagn Microbiol Infect Dis 2007 Feb; 57(2): 153–61PubMedCrossRefGoogle Scholar
  31. 31.
    Livermore DM. Of Pseudomonas, porins, pumps and carbapenems. J Antimicrob Chemother 2001 Mar; 47(3): 247–50PubMedCrossRefGoogle Scholar
  32. 32.
    Sakyo S, Tomita H, Tanimoto K, et al. Potency of carbapenems for the prevention of carbapenem-resistant mutants of Pseudomonas aeruginosa: the high potency of a new carbapenem doripenem. J Antibiot (Tokyo) 2006 Apr; 59(4): 220–8CrossRefGoogle Scholar
  33. 33.
    Burgess DS, Hall 2nd RG. In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. Diagn Microbiol Infect Dis 2004 May; 49(1): 41–6PubMedCrossRefGoogle Scholar
  34. 34.
    Pankuch G, Jacobs M, Appelbaum P. Antipneumococcal activity of ertapenem (MK-0826) compared to those of other agents. Antimicrob Agents Chemother 2002; 46(1): 42–6PubMedCrossRefGoogle Scholar
  35. 35.
    Mizunaga S, Kamiyama T, Fukuda Y, et al. Influence of inoculum size of Staphylococcus aureus and Pseudomonas aeruginosa on in vitro activties and in vivo efficacy of fluoroquino-lones and carbapenems. J Antimicrob Chemother 2005; 56: 91–6PubMedCrossRefGoogle Scholar
  36. 36.
    Carryn S, Van Bambeke F, Mingeot-Leclercq M-P, et al. Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluor-oquinolones against Listeria monocytogenes at clinically relevant concentrations. Antimicrob Agents Chemother 2002; 46(7): 2095–103PubMedCrossRefGoogle Scholar
  37. 37.
    Hoellman DB, Kelly LM, Credite K, et al. In vitro antianaerobic activity of ertapenem (MK-0826) comapred to seven other compounds. Antimicrob Agents Chemother 2002 Jan; 46: 220–4PubMedCrossRefGoogle Scholar
  38. 38.
    Kuti JL, Nicolau DP. Making the most of surveillance studies: summary of the OPTAMA program. Diagn Microbiol Infect Dis 2005; 53: 281–7PubMedCrossRefGoogle Scholar
  39. 39.
    Masterton RG, Kuti JL, Turner PJ, et al. The OPTAMA programme: utilizing MYSTIC (2002) to predict critical pharma-codynamic target attainment against nosocomial pathogens in Europe. J Antimicrob Chemother 2005 Jan; 55(1): 71–7PubMedCrossRefGoogle Scholar
  40. 40.
    Kuti JL, Nightingale CH, Nicolau DP. Optimizing pharmacodynamic target attainment using the MYSTIC antibiogram: data collected in North America in 2002. Antimicrob Agents Chemother 2004 Jul; 48(7): 2464–70PubMedCrossRefGoogle Scholar
  41. 41.
    Kiffer CR, Mendes C, Kuti JL, et al. Pharmacodynamic comparisons of antimicrobials against nosocomial isolates of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa from the MYSTIC surveillance program: the OPTAMA Program, South America 2002. Diagn Microbiol Infect Dis 2004 Jun; 49(2): 109–16PubMedCrossRefGoogle Scholar
  42. 42.
    DeRyke CA, Kuti JL, Nicolau DP. Changes in pharmacodynamic target attainment for antimicrobials over a 2-year period: results of the 2004 OPTAMA program in North America. Infect Dis Clin Pract 2007; 15(1): 26–34CrossRefGoogle Scholar
  43. 43.
    Sun HK, Kuti JL, Nicolau DP. Pharmacodynamics of antimicrobial for the empirical treatment of nosocomial pneumonia: a report from the OPTAMA program. Crit Care Med 2005; 33(10): 2222–7PubMedCrossRefGoogle Scholar
  44. 44.
    Maglio D, Kuti JL, Nicolau DP. Simulation of antibiotic pharmacodynamic exposure for the empiric treatment of nosocomial bloodstream infections: a report from the OPTAMA program. Clin Ther 2005 Jul; 27(7): 1032–42PubMedCrossRefGoogle Scholar
  45. 45.
    Ellis JM, Kuti JL, Nicolau DP. Pharmacodynamic evaluation of meropenem and cefotaxime for pediatric meningitis: a report from the OPTAMA program. Pediatric Drugs 2006; 8(2): 131–8PubMedCrossRefGoogle Scholar
  46. 46.
    Ong CT, Kuti JL, Nicolau DP; OPTAMA program. Pharmacodynamic modeling of imipenem-cilastatin, meropenem, and piperacillin-tazobactam for empiric therapy of skin and soft tissue infections: a report from the OPTAMA program. Surg Infect 2005; 6(4): 419–26CrossRefGoogle Scholar
  47. 47.
    Kotapati S, Kuti JL, Nicolau DP. Pharmacodynamic modelling of beta-lactam antibiotics for the empiric treatment of secondary peritonitis: a report from the OPTAMA program. Surg Infect 2005; 6(3): 297–304CrossRefGoogle Scholar
  48. 48.
    Ellis JM, Kuti JL, Nicolau DP. Use of Monte Carlo simulation to assess the pharmacodynamics of beta-lactams against Pseudomonas aeruginosa infections in children: a report from the OPTAMA program. Clin Ther 2005 Nov; 27(11): 1820–30PubMedCrossRefGoogle Scholar
  49. 49.
    Santos Filho L, Eagye KJ, Kuti JL, et al. Addressing resistance evolution in Pseudomonas aeruginosa using pharmacodynamic modelling: application to meropenem dosage and combination therapy. Clin Microbiol Infect 2007 Jun; 13(6): 579–85PubMedCrossRefGoogle Scholar
  50. 50.
    Lodise TP, Lomaestro BM, Drusano GL. Application of antimicrobial pharmacodynamic concepts into clinical practice: focus on beta-lactam antibiotics: insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy 2006 Sep; 26(9): 1320–32PubMedCrossRefGoogle Scholar
  51. 51.
    Krueger WA, Bulitta J, Kinzig-Schippers M, et al. Evaluation by Monte Carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers. Antimicrob Agents Chemother 2005 May 1; 49(5): 1881–9PubMedCrossRefGoogle Scholar
  52. 52.
    Kasiakou SK, Lawrence KR, Choulis N, et al. Continuous versus intermittent intravenous administration of antibacterials with time-dependent action: a systematic review of pharmacokinetic and pharmacodynamic parameters. Drugs 2005; 65(17): 2499–511PubMedCrossRefGoogle Scholar
  53. 53.
    Mouton JW, Touw DJ, Horrevorts AM, et al. Comparative pharmacokinetics of the carbapenems: clinical implications. Clin Pharmacokinet 2000 Sep; 39: 185–201PubMedCrossRefGoogle Scholar
  54. 54.
    Moon YSK, Chung KC, Gill MA. Pharmacokinetics of meropenem in animals, healthy volunteers, and patients. Clin Infect Dis 1997 Feb; 24 (Suppl. 2): 249–55CrossRefGoogle Scholar
  55. 55.
    Hextall A, Andrews JM, Donovan IA, et al. Intraperitoneal penetration of meropenem. J Antimicrob Chemother 1991; 28: 314–6PubMedCrossRefGoogle Scholar
  56. 56.
    Nyhlen A, Ljungberg B, Nilsson-Ehle I, et al. Pharmacokinetics of meropenem in febrile neutropenic patients. Eur J Clin Microbiol Infect Dis 1997 Nov; 16: 797–802PubMedCrossRefGoogle Scholar
  57. 57.
    Allegranzi B, Cazzadori A, Di Perri G, et al. Concentrations of single-dose meropenem (1 g iv) in bronchoalveolar lavage and epithelial lining fluid. J Antimicrob Chemother 2000 Aug; 46: 319–22PubMedCrossRefGoogle Scholar
  58. 58.
    Lovering AM, Vickery CJ, Watkin DS, et al. The pharmacokinetics of meropenem in surgical patients with moderate or severe infections. J Antimicrob Chemother 1995 Jul; 36: 165–72PubMedCrossRefGoogle Scholar
  59. 59.
    Bearden DT, Earle SB, McConnell DB, et al. Pharmacokinetics of meropenem in extreme obesity [abstract no. A-10 plus poster]. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2005 Dec 1; Washington DC, 2Google Scholar
  60. 60.
    Bui KQ, Ambrose PG, Nicolau DP, et al. Pharmacokinetics of high-dose meropenem in adult cystic fibrosis patients. Chemotherapy 2001; 47: 153–6PubMedCrossRefGoogle Scholar
  61. 61.
    Spriet I, Goyens J, Meersseman W, et al. Interaction between valproate and meropenem: a retrospective study. Ann Pharmacother 2007; 41(7–8): 1130–6PubMedGoogle Scholar
  62. 62.
    Linden P. Safety profile of meropenem: an updated review of over 6000 patients treated with meropenem. Drug Saf 2007; 30(8): 657–68PubMedCrossRefGoogle Scholar
  63. 63.
    Snedden S, Rudoy R, Arrieta A, et al. Meropenem versus cefotaxime-based therapy for the initial treatment of infants and children hospitalised with non-CNS infections. Clin Drug Invest 1999 Jan; 17: 9–20CrossRefGoogle Scholar
  64. 64.
    Principi N, Marchisio P. Meropenem compared with ceftazi-dime in the empiric treatment of acute severe infections in hospitalized children. J Chemother 1998; 10: 108–13PubMedGoogle Scholar
  65. 65.
    Schuler D. Safety and efficacy of meropenem in hospitalised children: randomised comparison with cefotaxime, alone and combined with metronidazole or amikacin. J Antimicrob Chemother 1995 Jul; 36 (Suppl. A): 99–108PubMedCrossRefGoogle Scholar
  66. 66.
    Mehtar S, Dewar EP, Leaper DJ, et al. A multi-centre study to compare meropenem and cefotaxime and metronidazole in the treatment of hospitalized patients with serious infections. J Antimicrob Chemother 1997 May; 39: 631–8PubMedCrossRefGoogle Scholar
  67. 67.
    Verwaest C. Meropenem versus imipenem/cilastatin as empirical monotherapy for serious bacterial infections in the intensive care unit. Clin Microbiol Infect 2000 Jun; 6: 294–302PubMedCrossRefGoogle Scholar
  68. 68.
    Colardyn F, Faulkner KL. Intravenous meropenem versus imipenem/cilastatin in the treatment of serious bacterial infections in hospitalized patients: Meropenem Serious Infection Study Group. J Antimicrob Chemother 1996 Sep; 38(3): 523–37PubMedCrossRefGoogle Scholar
  69. 69.
    Hou F, Li JT, Wu GP, et al. A randomized, controlled clinical trial on meropenem versus imipenem/cilastatin for the treatment of bacterial infections. Chin Med J (Engl) 2002 Dec; 115: 1849–54Google Scholar
  70. 70.
    Garau J, Blanquer J, Cobo L, et al. Prospective, randomised, multicenter study of meropenem versus imipenem/cilastatin as empiric monotherapy in severe nosocomial infections. Eur J Clin Microbiol Infect Dis 1997 Nov; 16: 789–96PubMedCrossRefGoogle Scholar
  71. 71.
    Solberg CO, Sjursen H. Safety and efficacy of meropenem in patients with septicaemia: a randomised comparison with cef-tazidime, alone or combined with amikacin. J Antimicrob Chemother 1995 Jul; 36 Suppl. A: 157–66PubMedCrossRefGoogle Scholar
  72. 72.
    Mouton YJ, Beuscart C. Empirical monotherapy with meropenem in serious bacterial infections: Meropenem Study Group. J Antimicrob Chemother 1995 Jul; 36 Suppl. A: 145–56PubMedCrossRefGoogle Scholar
  73. 73.
    Yakovlev S, Beloborodov V, Sidorenko S, et al. Adequacy and efficacy of initial empiric antibiotic treatments in severe nosocomial infections in ICU departments: results of multicentre randomised study [abstract no. P835 plus poster]. 17th European Congress of Clinical Microbiology and Infectious Diseases and the 25th International Congress of Chemotherapy; 2007 Mar 31; MunichGoogle Scholar
  74. 74.
    Jaspers CAJJ, Kieft H, Speelberg B, et al. Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients. Antimicrob Agents Chemother 1998 May; 42: 1233–8PubMedGoogle Scholar
  75. 75.
    Nichols RL, Smith JW, Geckler RW, et al. Meropenem versus imipenem/cilastin in the treatment of hospitalized patients with skin and soft tissue infections. South Med J 1995 Apr; 88(4): 397–404PubMedCrossRefGoogle Scholar
  76. 76.
    Klugman KP, Dagan R. Randomized comparison of meropenem with cefotaxime for treatment of bacterial meningitis: Meropenem Meningitis Study Group. Antimicrob Agents Chemother 1995 May; 39(5): 1140–6PubMedCrossRefGoogle Scholar
  77. 77.
    Odio CM, Puig JR, Feris JM, et al. Prospective, randomized, investigator-blinded study of the efficacy and safety of meropenem vs. cefotaxime therapy in bacterial meningitis in children. Pediatr Infect Dis J 1999 Jul; 18: 581–90Google Scholar
  78. 78.
    Schmutzhard E, Williams KJ, Vukmirovits G, et al. A randomised comparison of meropenem with cefotaxime or ceftriaxone for the treatment of bacterial meningitis in adults: Meropenem Meningitis Study Group. J Antimicrob Chemother 1995 Jul; 36 Suppl. A: 85–97PubMedCrossRefGoogle Scholar
  79. 79.
    Solomkin JS, Umeh O, Jiang J, et al. Doripenem vs. meropenem with an option for oral step-down therapy in the treatment of complicated intra-abdominal infections [abstract no. L-487]. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2007 Sep 17; Chicago (IL)Google Scholar
  80. 80.
    Lucasti C, Jasovich A, Umeh O, et al. Treatment of complicated intra-abdominal infections: doripenem versus meropenem. 17th European Congress of Clinical Microbiology and Infectious Diseases and the 25th International Congress of Chemotherapy 2007 Mar 31; (abstract no. P834 plus poster (Munich, Germany))Google Scholar
  81. 81.
    Malafaia O, Umeh O, Jiang J. Doripenem versus meropenem for the treatment of complicated intra-abdominal infections. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy: Final Program 2006 Sep 27; 188 (abstract no. L-1564b plus poster (California, USA))Google Scholar
  82. 82.
    Zanetti G, Harbarth SJ, Trampuz A, et al. Meropenem (1.5 g/ day) is as effective as imipenem/cilastatin (2 g/day) for the treatment of moderately severe intra-abdominal infections. Int J Antimicrob Agents 1999 Feb; 11(2): 107–13PubMedCrossRefGoogle Scholar
  83. 83.
    Basoli A, Meli EZ, Mazzocchi P, et al. Imipenem/cilastatin (1.5 g daily) versus meropenem (3.0 g daily) in patients with intraabdominal infections: results of a prospective, randomized, multicentre trial. Scand J Infect Dis 1997; 29(5): 503–8PubMedCrossRefGoogle Scholar
  84. 84.
    Geroulanos SJ. Meropenem versus imipenem/cilastatin in intra-abdominal infections requiring surgery. Meropenem Study Group. J Antimicrob Chemother 1995 Jul; 36 Suppl. A: 191–205CrossRefGoogle Scholar
  85. 85.
    Brismar B, Malmborg AS, Tunevall G, et al. Meropenem versus imipenem/cilastatin in the treatment of intra-abdominal infections. J Antimicrob Chemother 1995 Jan; 35(1): 139–48PubMedCrossRefGoogle Scholar
  86. 86.
    Huizinga WK, Warren BL, Baker LW, et al. Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections. J Antimicrob Chemother 1995 Jul; 36 Suppl A: 179–89PubMedCrossRefGoogle Scholar
  87. 87.
    Kempf P, Bauernfeind A, Muller A, et al. Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections. Infection 1996; 24(6): 473–9PubMedCrossRefGoogle Scholar
  88. 88.
    Condon RE, Walker AP, Sirinek KR, et al. Meropenem versus tobramycin plus clindamycin for treatment of intraabdominal infections: results of a prospective, randomized, double-blind clinical trial. Clin Infect Dis 1995 Sep; 21(3): 544–50PubMedCrossRefGoogle Scholar
  89. 89.
    Berne TV, Yellin AE, Appleman MD, et al. Meropenem versus tobramycin with clindamycin in the antibiotic management of patients with advanced appendicitis. J Am Coll Surg 1996 May; 182(5): 403–7PubMedGoogle Scholar
  90. 90.
    Oguz A, Karadeniz C, Citak EC, et al. Experience with cefepime versus meropenem as empiric monotherapy for neutropenia and fever in pediatric patients with solid tumors. Pediatr Hematol Oncol 2006; 23(3): 245–53PubMedCrossRefGoogle Scholar
  91. 91.
    Kutluk T, Kurne O, Akyuz C, et al. Cefepime vs. meropenem as empirical therapy for neutropenic fever in children with lymphoma and solid tumours. Pediatr Blood Cancer 2004; 42(3): 284–6Google Scholar
  92. 92.
    Feld R, DePauw B, Berman S, et al. Meropenem versus ceftazidime in the treatment of cancer patients with febrile neutropenia: a randomized, double-blind trial. J Clin Oncol 2000 Nov 1; 18: 3690–8PubMedGoogle Scholar
  93. 93.
    Fleischhack G, Hartmann C, Simon A, et al. Meropenem versus ceftazidime as empirical monotherapy in febrile neutropenia of paediatric patients with cancer. J Antimicrob Chemother 2001 Jun; 47: 841–53PubMedCrossRefGoogle Scholar
  94. 94.
    The Meropenem Study Group of Leuven. Equivalent efficacies of meropenem and ceftazidime as empirical monotherapy of febrile neutropenic patients. J Antimicrob Chemother 1995; 35: 185–200CrossRefGoogle Scholar
  95. 95.
    de la Camara R, Figuera A, Sureda A, et al. Meropenem versus ceftazidime plus amikacin in the treatment of febrile episodes in neutropenic patients: a randomized study. Haematologica 1997; 82: 668–75PubMedGoogle Scholar
  96. 96.
    Cometta A, Calandra T, Gaya H, et al. Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer: The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer and the Gruppo Italiano Malattie Ematologiche Maligne dell’Adulto Infection Program. Antimicrob Agents Chemother 1996 May; 40(5): 1108–15PubMedGoogle Scholar
  97. 97.
    Duzova A, Kutluk T, Kanra G, et al. Monotherapy with meropenem versus combination therapy with piperacillin plus amikacin as empiric therapy for neutropenic fever in children with lymphoma and solid tumors. Turk J Pediatr 2001; 43(2): 105–9PubMedGoogle Scholar
  98. 98.
    Reich G, Comely OA, Sandherr M, et al. Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial. Br J Haematol 2005; 130(2): 265–70PubMedCrossRefGoogle Scholar
  99. 99.
    Bartoloni A, Strohmeyer M, Corti G, et al. Multicenter randomized trial comparing meropenem (1.5 g daily) and imipenem/ cilastatin (2 g daily) in the hospital treatment of community-acquired pneumonia. Drugs Exp Clin Res 1999; 25(6): 243–52PubMedGoogle Scholar
  100. 100.
    Romanelli G, Cravarezza P, Pozzi A, et al. Carbapenems in the treatment of severe community-acquired pneumonia in hospitalized elderly patients: a comparative study against standard therapy. J Chemother 2002 Dec; 14(6): 609–17PubMedGoogle Scholar
  101. 101.
    Berman SJ, Sieger B,GecklerRW, et al. A comparative study of meropenem and ceftazidime in the treatment of patients hospitalized with community-acquired pneumonia. Curr Ther Res Clin Exp 1997; 58(12): 903–16CrossRefGoogle Scholar
  102. 102.
    Manes G, Uomo I, Menchise A, et al. Timing of antibiotic prophylaxis in acute pancreatitis: a controlled randomized study with meropenem. Am J Gastroenterol 2006; 101(6): 1348–53PubMedCrossRefGoogle Scholar
  103. 103.
    Manes G, Rabitti PG, Menchise A, et al. Prophylaxis with meropenem of septic complications in acute pancreatitis: a randomized, controlled trial versus imipenem. Pancreas 2003 Nov; 27(4): e79–83PubMedCrossRefGoogle Scholar
  104. 104.
    Aksoylar S, Cetingul N, Kantar M, et al. Meropenem plus amikacin versus piperacillin-tazobactam plus netilmicin as empiric therapy for high-risk febrile neutropenia in children. Pediatr Hematol Oncol 2004 Mar; 21(2): 115–23PubMedCrossRefGoogle Scholar
  105. 105.
    Byrne S, Maddison J, Connor P, et al. Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. infections in cystic fibrosis patients. J Antimicrob Chemother 1995 Jul; 36 (Suppl. A): 135–43Google Scholar
  106. 106.
    Latzin P, Fehling M, Bauernfeind A, et al. Efficacy and safety of intravenous meropenem and tobramycin versus ceftazidime and tobramycin in cystic fibrosis. J Cyst Fibrös 2008; 7(2): 142–6PubMedCrossRefGoogle Scholar
  107. 107.
    Fabian TC, File TM, Embil JM, et al. Meropenem versus imipenem-cilastatin for the treatment of hospitalized patients with complicated skin and skin structure infections: results of a multicenter, randomized, double-blind comparative study. Surg Infect (Larchmt) 2005; 6(3): 269–82CrossRefGoogle Scholar
  108. 108.
    Wilson SE. Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections. Clin Infect Dis 1997 Feb; 24 Suppl. 2: S197-206Google Scholar
  109. 109.
    Dellinger EP, Tellado JM, Soto NE, et al. Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study. Ann Surg 2007 May; 245(5): 674–83PubMedCrossRefGoogle Scholar
  110. 110.
    Blumer JL, Saiman L, Konstan MW, et al. The efficacy and safety of meropenem and tobramycin vs ceftazidime and tobramycin in the treatment of acute pulmonary exacerbations in patients with cystic fibrosis. Chest 2005 Oct; 128(4b): 2336–46PubMedCrossRefGoogle Scholar
  111. 111.
    Sieger B, Berman SJ, Geckler RW, et al. Empiric treatment of hospital-acquired lower respiratory tract infections with meropenem or ceftazidime with tobramycin: a randomized study. Meropenem Lower Respiratory Infection Group. Crit Care Med 1997 Oct; 25(10): 1663–70Google Scholar
  112. 112.
    Alvarez Lerma F. Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia. J Chemother 2001 Feb; 13(1): 70–81PubMedGoogle Scholar
  113. 113.
    Heyland DK, Dodek P, Muscedere J, et al. Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med 2008; 36(2): 1–8Google Scholar
  114. 114.
    Shah PM, Heller A, Fuhr HG, et al. Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients. Infection 1996; 24(6): 480–4PubMedCrossRefGoogle Scholar
  115. 115.
    Paul M, Yahav D, Fraser A, et al. Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother 2006 Feb; 57(2): 176–89PubMedCrossRefGoogle Scholar
  116. 116.
    Embil JM, Soto NE, Melnick DA. A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus. Clin Ther 2006 Aug; 28(8): 1164–74PubMedCrossRefGoogle Scholar
  117. 117.
    Cox CE, Holloway WJ, Geckler RW. A multicenter comparative study of meropenem and imipenem/cilastatin in the treatment of complicated urinary tract infections in hospitalized patients. Clin Infect Dis 1995 Jul; 21: 86–92PubMedCrossRefGoogle Scholar
  118. 118.
    Maggioni P, Di Stefano F, Facchini V, et al. Treatment of obstetric and gynecologic infections with meropenem: comparison with imipenem/cilastatin. J Chemother 1998 Apr; 10: 114–21PubMedGoogle Scholar
  119. 119.
    Hemsell DL, Martens MG, Faro S, et al. A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women. Clin Infect Dis 1997 Feb; 24 (Suppl. 2): 222–30CrossRefGoogle Scholar
  120. 120.
    Finch RG, Pemberton K, Gildon KM. Pneumonia: the impact of risk factors on the outcome of treatment with meropenem and ceftazidime. J Chemother 1998; 10(1): 35–46PubMedGoogle Scholar
  121. 121.
    Norrby SR. Carbapenems in serious infections: a risk-benefit assessment. Drug Saf 2000 Mar; 22: 191–4PubMedCrossRefGoogle Scholar
  122. 122.
    Norrby SR, Gildon KM. Safety profile of meropenem: a review of nearly 5,000 patients treated with meropenem. Scand J Infect Dis 1999; 31(1): 3–10PubMedCrossRefGoogle Scholar
  123. 123.
    PrimaxinRM I.V. (Imipenem and cilastatin for injection): US prescribing information. Merck & Co, 2007 OctGoogle Scholar
  124. 124.
    Prescott Jr WA, Kusmierski KA. Clinical importance of carbapenem hypersensitivity in patients with self-reported and documented penicillin allergy. Pharmacotherapy 2007; 27(1): 137–42PubMedCrossRefGoogle Scholar
  125. 125.
    Prescott Jr WA, DePestel DD, Ellis JJ, et al. Incidence of carbapenem-associated allergic-type reactions among patients with versus patients without a reported penicillin allergy. Clin Infect Dis 2004 Apr 15; 38(8): 1102–7PubMedCrossRefGoogle Scholar
  126. 126.
    Edwards SJ, Campbell HE, Plumb JM. Cost-utility analysis comparing meropenem with imipenem plus cilastatin in the treatment of severe infections in intensive care. Eur J Health Econ 2006 Mar; 7(1): 72–8PubMedCrossRefGoogle Scholar
  127. 127.
    DeRyke CA, Kuti JL, Nicolau DP. Pharmacodynamic target attainment as a surrogate marker for antibiotic efficacy in cost-effectiveness analyses [abstract no. O-1465 plus poster]. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2006 Sep 17–20; San Francisco (CA), 444Google Scholar
  128. 128.
    Kulikov A, Krysanov I, Lomakin A. Antibiotic therapy of nosocomial infection in the intensive care unit: a cost-effectiveness analysis [abstract no. PIN4 plus poster]. Value Health 2006; 9: A299CrossRefGoogle Scholar
  129. 129.
    Edwards SJ, Emmas CE, Campbell HE. Systematic review comparing meropenem with imipenem plus cilastatin in the treatment of severe infections. Curr Med Res Opin 2005; 21(5): 785–94PubMedCrossRefGoogle Scholar
  130. 130.
    Tumbarello M, Sanguinetti M, Montuori E, et al. Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother 2007 Jun; 51(6): 1987–94PubMedCrossRefGoogle Scholar
  131. 131.
    Rello J, Gallego M, Mariscal D, et al. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 1997 Jul; 156(1): 196–200PubMedGoogle Scholar
  132. 132.
    Kollef MH. Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients. Clin Infect Dis 2000 Sep; 31 Suppl. 4: S131-8Google Scholar
  133. 133.
    Kollef MH, Sherman G, Ward S, et al. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 1999 Feb; 115(2): 462–74PubMedCrossRefGoogle Scholar
  134. 134.
    Amyes SG, Walsh FM, Bradley JS. Best in class: a good principle for antibiotic usage to limit resistance development? J Antimicrob Chemother 2007 May; 59(5): 825–6PubMedCrossRefGoogle Scholar
  135. 135.
    Felmingham D. The need for antimicrobial resistance surveillance. J Antimicrob Chemother 2002 Sep; 50 Suppl. S1: 1–7PubMedCrossRefGoogle Scholar
  136. 136.
    Unal S, Garcia-Rodriguez JA. Activity of meropenem and comparators against Pseudomonas aeruginosa and Acinetobacter spp. isolated in the MYSTIC Program, 2002–2004. Diagn Microbiol Infect Dis 2005 Dec; 53(4): 265–71PubMedCrossRefGoogle Scholar
  137. 137.
    Turner PJ. Meropenem and imipenem activity against Pseudomonas aeruginosa isolates from the MYSTIC Program. Diagn Microbiol Infect Dis 2006 Nov; 56(3): 341–4PubMedCrossRefGoogle Scholar
  138. 138.
    Ortho-McNeil Pharmaceutical I. DoribaxTM (doripenem for injection) for intravenous infusion: US prescribing information. 2007 OctGoogle Scholar
  139. 139.
    Keating GM, Perry CM. Ertapenem: a review of its use in the treatment of bacterial infections. Drugs 2005; 65(15): 2151–78PubMedCrossRefGoogle Scholar
  140. 140.
    Sader HS, Gales AC. Emerging strategies in infectious diseases: new carbapenem and trinem antibacterial agents. Drugs 2001; 61(5): 553–64PubMedCrossRefGoogle Scholar
  141. 141.
    Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 2005 Nov 15; 41(10): 1373–406PubMedCrossRefGoogle Scholar
  142. 142.
    Solomkin JS, Mazuski JE, Baron EJ, et al. Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections. Clin Infect Dis 2003 Oct 15; 37(8): 997–1005PubMedCrossRefGoogle Scholar
  143. 143.
    Hughes WT, Armstrong D, Bodey GP, et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002 Mar 15; 34(6): 730–51PubMedCrossRefGoogle Scholar
  144. 144.
    Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004 Nov 1; 39(9): 1267–84PubMedCrossRefGoogle Scholar
  145. 145.
    American Thoracic Society. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005 Feb 15; 171(4): 388–416CrossRefGoogle Scholar
  146. 146.
    Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections. Eur Respir J 2005; 26(6): 1138–80PubMedCrossRefGoogle Scholar
  147. 147.
    Naber KG, Bishop MC, Bjerklund-Johansen TE, et al. Guidelines on the management of urinary and male genital tract infections [online]. Available from URL: http://www.uroweb.org/professional-resources/guidelines/ [Accessed 2008 Feb 18]
  148. 148.
    Banerjee D, Stableforth D. The treatment of respiratory Pseudomonas infection in cystic fibrosis: what drug and which way? Drugs 2000; 60: 1053–64PubMedCrossRefGoogle Scholar
  149. 149.
    Paterson DL, Bonomo RA. Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev 2005 Oct; 18(4): 657–86PubMedCrossRefGoogle Scholar
  150. 150.
    Gilad J, Carmeli Y. Treatment options for multidrug-resistant Acinetobacter species. Drugs 2008; 68(2): 165–89PubMedCrossRefGoogle Scholar
  151. 151.
    Munoz-Price LS, Weinstein RA. Acinetobacter infection. N Engl J Med 2008; 358(12): 1271–81PubMedCrossRefGoogle Scholar
  152. 152.
    Queenan AM, Bush K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev 2007; 20(3): 440–58PubMedCrossRefGoogle Scholar

Copyright information

© Adis Data Information BV 2008

Authors and Affiliations

  • Claudine M. Baldwin
    • 1
    • 2
  • Katherine A. Lyseng-Williamson
    • 1
    • 2
  • Susan J. Keam
    • 1
    • 2
  1. 1.Wolters Kluwer Health ¦ AdisMairangi Bay, North Shore, 0754, AucklandNew Zealand
  2. 2.Wolters Kluwer HealthConshohockenUSA

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