, Volume 67, Issue 8, pp 1109–1124 | Cite as

Hormone-Refractory Prostate Cancer

Where are We Going?
  • Giuseppe Di Lorenzo
  • Riccardo Autorino
  • William D. Figg
  • Sabino De Placido
Leading Article


This article addresses the current status of therapeutic options in the management of hormone-refractory prostate cancer (HRPC). Following the publication of two landmark randomised trials, docetaxel chemotherapy is now the standard of care for men with metastatic HRPC. However, the benefit of this treatment is limited. Trials are now focusing on improving the efficacy of docetaxel by combining it with novel biological agents. Several new docetaxel-based combinations are under evaluation and promising results have been found for the combination of docetaxel with angiogenesis inhibitors. Early phase III trial data for atrasentan appear interesting. New cytotoxic agents such as satraplatin and ixabepilone are being investigated in several ongoing studies in order to define their role as second-line treatments of HRPC. Vaccine therapy offers an active immunological approach for combating malignancy in a targeted manner.


Prostate Cancer Docetaxel Androgen Receptor Zoledronic Acid Vinorelbine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No sources of funding were used to assist in the preparation of this article. The authors have no conflicts of interest that are directly relevant to the content of this article.


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Copyright information

© Adis Data Information BV 2007

Authors and Affiliations

  • Giuseppe Di Lorenzo
    • 1
  • Riccardo Autorino
    • 2
  • William D. Figg
    • 3
  • Sabino De Placido
    • 1
  1. 1.Department of Clinical and Molecular OncologyFederico II UniversityNaplesItaly
  2. 2.Urologic ClinicSecond UniversityNaplesItaly
  3. 3.Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer ResearchNational Cancer InstituteBethesdaUSA

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