Drugs

, Volume 65, Issue 16, pp 2299–2306 | Cite as

Low-Dose Ethinylestradiol/Levonorgestrel

Adis Drug Profile

Abstract

▴ Low-dose ethinylestradiol/levonorgestrel 20μg/ 100μg is a combined oral contraceptive that prevents pregnancy primarily by inhibiting ovulation.

▴ The Pearl index (pregnancies per 100 woman-years of use) with ethinylestradiol/levonorgestrel 20μg/ 100μg was 0.88 and the cumulative pregnancy rate was 1.9% at the end of a 3-year open-label trial (1708 women with 26 554 evaluable cycles). The contraceptive efficacy of ethinylestradiol/levonorgestrel 20μg/100μg was similar to that of other low-dose combined oral contraceptives containing ethinylestradiol 20 or 35μg in a 6-cycle trial (463 evaluable women).

▴ Ethinylestradiol/levonorgestrel 20μg/100μg is well tolerated; adverse events were those commonly associated with combined oral contraceptives. Headache and metrorrhagia (2% of women) were the most common adverse events leading to treatment discontinuation in the 3-year trial.

▴ Cycle control in open-label trials in women receiving up to 36 cycles of ethinylestradiol/levonorgestrel 20μg/100μg was generally good, with the incidence of intermenstrual bleeding being highest during the first few cycles of use and decreasing thereafter.

Keywords

Oral Contraceptive Levonorgestrel Ethinylestradiol Combine Oral Contraceptive Contraceptive Efficacy 

Notes

Acknowledgements

At the request of the journal, Wyeth Pharmaceuticals Inc. provided a non-binding review of this article.

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Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  1. 1.Adis International LimitedMairangi Bay, AucklandNew Zealand

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