, Volume 65, Supplement 1, pp 1–6 | Cite as

Historical Perspective of Gastric Acid Inhibition

Review Article


The inhibition of gastric secretion has been a therapeutic objective for decades. A variety of pharmacologic and non-pharmacologic approaches have been proposed throughout history. Among the non-pharmacologic proposals, gastric surgery was widely used until effective drugs were available. Initially antacids and later anti-cholinergics, H2 blockers and proton pump inhibitors took the predominant position. Finally, Helicobacter pylori eradication has been the milestone for the cure of peptic ulcers.


Esomeprazole Reflux Oesophagitis Rabeprazole Nizatidine Truncal Vagotomy 
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Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  1. 1.Department of Medical Pathology, Gastroenterology Service‘San Carlos’ Clinical University Hospital, Complutense UniversityMadridSpain

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