, Volume 62, Issue 4, pp 567–575 | Cite as

Issues of Adherence to Immunosuppressant Therapy After Solid-Organ Transplantation

  • Marie A. Chisholm
Leading Article


Nonadherence to immunosuppressant therapy constitutes a major barrier to post-transplant care. Failure of transplant recipients to take prescribed drugs properly may not only be a significant obstacle to optimal graft function but it may also result in decreased quality of life and productivity, increased morbidity and healthcare cost, and death. Despite the obvious importance of adherence to immunosuppressant therapy, nonadherence is frequent among transplant recipients, with rates ranging from 2 to 68%.

This manuscript briefly discusses several issues concerning adherence to immunosuppressant therapy of solid-organ transplant recipients; presents a literature review concerning adherence to immunosuppressant therapy by solid-organ transplant recipients; and suggests strategies that may be used to enhance medication adherence. Although many of the studies have results that conflict concerning factors associated with immunosuppressive nonadherence, most of the investigators concluded that nonadherent behaviour is usually not predictable. Because of possible adverse events, emphasis should be placed on increasing medication adherence in all transplant recipients.


Transplant Recipient Immunosuppressive Therapy Medication Adherence Serum Drug Concentration Medication Nonadherence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by a grant from the Carlos and Marguerite Mason Trust Fund.


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Copyright information

© Adis International Limited 2002

Authors and Affiliations

  1. 1.Department of Clinical and Administrative SciencesUniversity of Georgia College of PharmacyAugustaUSA
  2. 2.Department of MedicineMedical College of Georgia CJ-1020AugustaUSA

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