Drugs

, Volume 58, Supplement 2, pp 121–122 | Cite as

Activity of Trovafloxacin Against Topoisomerases and GyrA/Gr1A Mutants of Staphylococcus aureus

  • Thomas D. Gootz
  • Richard P. Zaniewski
  • Suzanne L. Haskell
  • Frank S. Kaczmarek
  • Alison E. Maurice
Poster Presentations Extended Abstract

References

  1. 1.
    Brighty K, Gootz T. The chemistry and biological profile of trovafloxacin. J Antimicrob Chemother 1997; Suppl. B, 39: 1–14PubMedCrossRefGoogle Scholar
  2. 2.
    Kaatz G, Seo S. Topoisomerase mutations in fluoroquinolone-resistant and methicillin-susceptible and -resistant clinical isolates of Staphylococcus aureus. Antimicrob Agents Chemother 1998; 42: 197–8PubMedGoogle Scholar
  3. 3.
    Pan X-S, Fisher ML. Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase intravenous by quinolones. Antimicrob Agents Chemother 1997; 41: 471–4PubMedGoogle Scholar

Copyright information

© Adis International Limited 1999

Authors and Affiliations

  • Thomas D. Gootz
    • 1
  • Richard P. Zaniewski
    • 1
  • Suzanne L. Haskell
    • 1
  • Frank S. Kaczmarek
    • 1
  • Alison E. Maurice
    • 1
  1. 1.Central Research DivisionPfizer, Inc.GrotonUSA

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