, Volume 54, Supplement 6, pp 4–10 | Cite as

Colonisation and Infection with Resistant Gram-Positive Cocci

Epidemiology and Risk Factors
  • Otto Cars


Only a few years after the introduction of penicillin, resistant staphylococci were isolated in hospitals. This situation has led to the development of semisyn-thetic penicillins. Today, multiresistant Gram-positive bacteria have become an increasing problem in both hospitals and the community, frequently leaving the glycopeptides as the only therapeutic option. Notable problem pathogens are methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci and glycopeptide-resistant enterococci in the nosocomial environment, and penicillin-resistant Streptococcuspneumoniae in the community. In the hospital setting, as well as in the community and in animal husbandry, crowding and poor hygiene can facilitate the spread of resistant bacteria selected by antibiotic usage. However, the precise epidemiology and frequency of each drug-resistant pathogen depends on geographical location, the patient group involved and previous antibiotic use. Active measures need to be taken to reduce the spread of these pathogens and thus preserve the efficacy of available antibiotics.


Vancomycin Glycopeptide Teicoplanin Vancomycin Resistant Enterococcus Penicillin Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1997

Authors and Affiliations

  • Otto Cars
    • 1
  1. 1.Department of Infectious DiseasesUppsala University HospitalUppsalaSweden

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