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The Management of Malignant Hypercalcaemia

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Summary

Malignant hypercalcaemia is a common problem for cancer clinicians. However, the management of this condition has altered substantially over the last 10 years and the condition is usually amenable to modern treatment.

A number of effective pharmacological agents are available in current practice. Bisphosphonate drugs, particularly clodronate and pamidronate, are confirmed as the mainstay of modern management. Bisphosphonates are effective and well tolerated when given intravenously. Many aspects of the actions of bisphosphonates are not well understood, and knowledge of their pharmacokinetics is limited.

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Authors and Affiliations

  1. Yorkshire Regional Centre for Cancer Treatment, Cookridge Hospital, Hospital Lane, Cookridge, West Yorkshire, LS16 6QB, England

    Julie Watters, Georgina Gerrard &  David Dodwell

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  1. Julie Watters
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  2. Georgina Gerrard
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  3. David Dodwell
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Watters, J., Gerrard, G. & Dodwell, D. The Management of Malignant Hypercalcaemia. Drugs 52, 837–848 (1996). https://doi.org/10.2165/00003495-199652060-00005

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