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Drugs

, Volume 47, Supplement 2, pp 42–51 | Cite as

Effects of Estrogen Treatment on Arterial Wall Structure and Function

  • Thomas B. Clarkson
  • Mary S. Anthony
  • Karen Potvin Klein
Article

Summary

Premenopausal women are relatively protected against coronary heart disease (CHD) compared with men, but lose this advantage after surgical or natural menopause. Consequently, estrogens are believed to confer significant protection against coronary artery atherosclerosis (CAA). In addition, epidemiological studies have shown lower rates of CHD in postmenopausal users of estrogen replacement therapy than in women not taking hormone therapy. The cynomolgus monkey model (Macaca fascicularis) has proved valuable for gaining a better understanding of the effects of estrogen on coronary artery function and CAA. We have found that premenopausal cynomolgus monkeys have less CAA than male monkeys and surgically postmenopausal female monkeys, and that the hyperestrogenic state of pregnancy further inhibits CAA progression. Ovarian-deficient stressed females had more extensive CAA and impaired vascular function compared with unstressed monkeys, and estrogen-treated females (premenopausal or postmenopausal) had less CAA than untreated monkeys. The treatment effect in this model appears to be partially mediated by a decrease in low density lipoprotein uptake and/or degradation, and an improvement in coronary artery vascular function.

Keywords

Cynomolgus Monkey Estrogen Replacement Therapy Cynomolgus Macaque Coronary Artery Atherosclerosis Lower High Density Lipoprotein Cholesterol Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • Thomas B. Clarkson
    • 1
  • Mary S. Anthony
    • 1
  • Karen Potvin Klein
    • 1
  1. 1.Department of Comparative Medicine and the Comparative Medicine Clinical Research CenterThe Bowman Gray School of Medicine of Wake Forest UniversityWinston-SalemUSA

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