Effects of Estrogen Treatment on Arterial Wall Structure and Function
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Premenopausal women are relatively protected against coronary heart disease (CHD) compared with men, but lose this advantage after surgical or natural menopause. Consequently, estrogens are believed to confer significant protection against coronary artery atherosclerosis (CAA). In addition, epidemiological studies have shown lower rates of CHD in postmenopausal users of estrogen replacement therapy than in women not taking hormone therapy. The cynomolgus monkey model (Macaca fascicularis) has proved valuable for gaining a better understanding of the effects of estrogen on coronary artery function and CAA. We have found that premenopausal cynomolgus monkeys have less CAA than male monkeys and surgically postmenopausal female monkeys, and that the hyperestrogenic state of pregnancy further inhibits CAA progression. Ovarian-deficient stressed females had more extensive CAA and impaired vascular function compared with unstressed monkeys, and estrogen-treated females (premenopausal or postmenopausal) had less CAA than untreated monkeys. The treatment effect in this model appears to be partially mediated by a decrease in low density lipoprotein uptake and/or degradation, and an improvement in coronary artery vascular function.
KeywordsCynomolgus Monkey Estrogen Replacement Therapy Cynomolgus Macaque Coronary Artery Atherosclerosis Lower High Density Lipoprotein Cholesterol Level
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- Adams MR, Williams JK, Clarkson TB, Jayo MJ. Effects of oestrogens and progestogens on coronary atherosclerosis and osteoporosis of monkeys. In Christiansen (Ed.) Baillière’s clinical obstetrics and gynaecology; international practice and research: hormone replacement and its impact on osteoporosis, pp. 915–934, Baillière Tindall, London, 1991Google Scholar
- Chaitman BR, Bourassa MG, Lam J, Hung J. Noninvasive diagnosis of coronary heart disease in women. In Eaker et al. (Eds) Coronary heart disease in women: proceedings of an N.I.H. workshop, pp. 222–228, Haymarket Doyma Inc., New York, 1987Google Scholar
- Clarkson TB, Adams MR, Williams JK, Wagner JD. Clinical implications of animal models of gender difference in heart disease. In Douglas P (Ed.) Cardiovascular health and disease in women, chap. 15, pp. 283–302, WB Saunders, Philadelphia, 1993Google Scholar
- Eaker ED, Castelli WP. Coronary heart disease and its risk factors among women in the Framingham study. In Eaker et al. (Eds) Coronary heart disease in women: proceedings of an N.I.H. workshop, pp. 122–130, Haymarket Doyma Inc., New York, 1987Google Scholar
- Koritnik DR, Clarkson TB, Adams MR. Cynomolgus macaques as models for evaluating effects of contraceptive steroids on plasma lipoproteins and coronary artery atherosclerosis. In Blye et al. (Eds) Contraceptive steroids: pharmacology and safety, pp. 303–319, Plenum Press, New York, 1986CrossRefGoogle Scholar
- Tofler GH, Stone PH, Muller JE, Braunwald E. Clinical manifestations of coronary heart disease in women. In Eaker et al. (Eds) Coronary heart disease in women: proceedings of an N.I.H. workshop, pp. 215–221, Haymarket Doyma Inc., New York, 1987Google Scholar
- Wagner JD, Clarkson TB, St. Clair RW, Schwenke DC, Adams MR. Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. Journal of Clinical Investigation 88: 1995–2002, 1991PubMedCrossRefGoogle Scholar