- 9 Downloads
The potential value of meta-analysis has captured the imagination of many investigators. Epidemiologists have, appropriately, greeted its broad application with considerable caution, yet practical matters, such as the need to consolidate and extract information from available data, have forced a more accepting approach.
Meta-analysis has been employed in many clinical settings to evaluate efficacy and safety of a variety of therapeutic interventions. It is likely that it will continue to have a role in extrapolating data from clinical trials for use in the clinic.
KeywordsBreast Cancer Fluoxetine Quinidine Streptokinase Flecainide
Unable to display preview. Download preview PDF.
- Altman LK. New method of analyzing health data stirs debate. New York Times, Aug 21, pp. B5, B9, 1990Google Scholar
- Bigger JR Jr, Fleiss JL, Kleiger R, Miller JP, Rolnitzky LM. Multicenter Post-Infarction Research Group. The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the two years after myocardial infarction. Circulation 69: 250–258, 1984Google Scholar
- Cardiac Arrhythmia Suppression Trial (CAST) Investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. New England Journal of Medicine 321: 1406–1412, 1989Google Scholar
- Coplen SE, Antman EM, Berlin JA, Hewitt P, Chalmers TC. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials. Circulation 82: 1106–1116, 1990Google Scholar
- Fedorkow DM. Aspirin to prevent pregnancy-induced hypertension: a meta analysis. American College of Physicians’ Journal Club (Nov/Dec), p. 80, 1992Google Scholar
- Glass GV. Primary, secondary, and meta-analysis of research. Education Research 5: 3–8, 1976Google Scholar
- Hillner BE. Estrogen replacement and breast cancer: a metaanalysis. American College of Physicians’ Journal Club (May/June), p. 82, 1991Google Scholar
- Hommes DW, Bura A, Mazzolai L, Buller HR, ten Cate JW. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Annals Internal Medicine 116: 279–284, 1992Google Scholar
- Imperiale TF, Petrulis AS. A meta-analysis of low-dose aspirin for the prevention of pregnancy-induced hypertensive disease. Journal of the American Medical Association 266: 261–265,1991Google Scholar
- Levy G. Publication bias: its implications for clinical pharmacology. Clinical Pharmacology and Therapeutics 52: 115–119, 1991Google Scholar
- Light RJ, Smith PV. Accumulating evidence: procedures for resolving contradictions among different research studies. Harvard Education Review 41: 429–471, 1971Google Scholar
- Lipid Research Clinics Program. The Lipid Research Clinics coronary primary prevention trials results. I. Reduction in incidence of coronary heart disease. Journal of the American Medical Association 251: 351–364, 1984Google Scholar
- Philbrick JT. Subcutaneous versus intravenous heparin for thrombosis: a meta-analysis. American College of Physicians’ Journal Club (May/June), p. 76, 1992Google Scholar
- Walker AM, Gregg GS, Zawel J, Lanes SF. Treatment efficacy of cyclosporine in renal transplantation. A quantitative review of all randomized clinical trials. Journal of Clinical Research and Pharmacoepidemiology 4: 161–173, 1990Google Scholar