Drugs

, Volume 45, Issue 5, pp 623–636 | Cite as

Folates and Psychiatric Disorders

Clinical Potential
  • R. Crellin
  • T. Bottiglieri
  • E. H. Reynolds
Leading Article

Keywords

Folate Folate Deficiency Serum Folate Megaloblastic Anaemia Biopterin 

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References

  1. Abalan F, Subra G, Picard M, Boueilh P. Fréquence des déficiences en vitamine B12 ou en acide folique chez les patientes admises en géranto-psychiatrie. Encéphale 10: 9–12, 1984PubMedGoogle Scholar
  2. Abou-Saleh MT, Spalding E, Kellett J. Folate deficiency in dementia. British Journal of Psychiatry 148: 336–337, 1986CrossRefGoogle Scholar
  3. Agnoli A, Andreoli V, Casacchia M, Serbo R. Effect of S-adenosyl 1-methionine (SAMe) upon depressive symptons. Journal of Psychiatric Research 13: 43–54, 1976PubMedCrossRefGoogle Scholar
  4. Baldessarini RJ. Neuropharmacology of S-adenosyl methionine. American Journal of Medicine 83 (Suppl. 5a): 95–103, 1987PubMedCrossRefGoogle Scholar
  5. Bell KM, Plom L, Bunney WE. S-adenosyl methionine treatment of depression; a controlled trial. American Journal of Psychiatry 145: 1110–1114, 1988PubMedGoogle Scholar
  6. Blair JA, Morar C, Hamon CGB, Barford PA, Pheasant AE, et al. Tetrahydrobiopterin metabolism in depression. Lancet 2: 163, 1984PubMedCrossRefGoogle Scholar
  7. Bleyer WA, Drake JC, Chabner BA. Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukaemia. New England Journal of Medicine 289: 770–773, 1973PubMedCrossRefGoogle Scholar
  8. Bober MJ. Senile dementia and nutrition. British Medical Journal 288: 1234, 1984PubMedCrossRefGoogle Scholar
  9. Boles JM, Youinou P, Garre M, Jouquan I, Legendre JM, et al. La carence en acide folique: fréquence chez 480 malades. Conséquences sur la phagocytose des polynucléaires neutrophiles. Revue de Medecine Interne 3: 51–56, 1982PubMedCrossRefGoogle Scholar
  10. Botez MI, Cadotte M, Beaulieu R, Pichette LP, Pison C. Neurological disorders responsive to folic acid therapy. Canadian Medical Association Journal 115: 217–222, 1976PubMedGoogle Scholar
  11. Botez MI, Reynolds EH (Eds). Folic acid in neurology, psychiatry and internal medicine, Raven Press, New York, 1979Google Scholar
  12. Botez MI, Botez T, Leveille J, Bielmann P, Cadotte M. Neurological correlates of folic acid deficiency: facts and hypotheses. In Botez & Reynolds (Eds) Folic acid in neurology, psychiatry and internal medicine, pp. 435–461, Raven Press, New York, 1979aGoogle Scholar
  13. Botez MI, Young SN, Bachevalier J, Gauthier S. Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat. Nature 278: 182–183, 1979bPubMedCrossRefGoogle Scholar
  14. Botez MI, Peyronnard JM, Bérubé L, Labrecque R. Relapsing neuropathy, cerebral atrophy and folate deficiency. Applied Neurophysiology 42: 171–183, 1979cPubMedGoogle Scholar
  15. Botez MI, Young SN, Bachevalier J, Gauthier S. The effect of folic acid and vitamin B12 deficiency on 5-hydroxyindoleacetic acid in human cerebrospinal fluid. Annals of Neurology 12: 479–484, 1982PubMedCrossRefGoogle Scholar
  16. Botez MI, Botez T, Maag V. The Wechsler subtests in mild organic brain damage associated with folate deficiency. Psychological Medicine 14: 431–437, 1984PubMedCrossRefGoogle Scholar
  17. Botez MI, Botez T. Neurologic and psychiatric illnesses and folate deficiency: a review. Recent knowledge on iron and folate deficiencies in the world. Colloque INSERM 197: 429–440, 1990Google Scholar
  18. Bottiglieri T, Laundy M, Martin R, Carney MWP, Nissenbaum H, et al. S-adenosyl methionine influences monoamine metabolism. Lancet 2: 224, 1984PubMedCrossRefGoogle Scholar
  19. Bottiglieri T, Carney MWP, Edeh J, Laundy M, Martin R, et al. A biochemical study of depressed patients receiving S-adenosyl methionine (SAM). In Borchardt RT et al. (Eds) Biological methylation and drug design, pp. 327–338, Humana Press, Clifton, NJ, 1986CrossRefGoogle Scholar
  20. Bottiglieri T, Hyland K, Laundy M, Godfrey PSA, Carney MWP, et al. Folate, homocysteine and monoamine metabolism in depression. Pteridines 3: 151–152, 1992aGoogle Scholar
  21. Bottiglieri T, Hyland K, Laundy M, Godfrey PSA, Carney MWP, et al. Folate deficiency, biopterin and monoamine metabolism in depression. Psychological Medicine 22: 871–876, 1992bPubMedCrossRefGoogle Scholar
  22. Brocker, Lebel C, Maurin H, Lods JC. Carences en folates chez sûjets âges: interêt de leur correction dans le traitement des troubles du comportement. Semaine des Hôpitaux de Paris 62: 2135–2139, 1986Google Scholar
  23. Carney MWP. Serum folate values in 423 psychiatric patients. British Medical Journal 4: 512–516, 1967PubMedCrossRefGoogle Scholar
  24. Carney MWP. Neuropharmacology of S-adenosyl methionine. Clinical Neuropharmacology 9: 235–243, 1986PubMedCrossRefGoogle Scholar
  25. Carney MWP, Sheffield BF. Associations of subnormal serum folate and vitamin B12 values and effects of replacement therapy. Journal of Nervous and Mental Disease 150: 404–412, 1970PubMedCrossRefGoogle Scholar
  26. Carney MWP, Sheffield BF. Serum folic acid and B12 in 272 psychiatric in-patients. Psychological Medicine 8: 139–144, 1978PubMedCrossRefGoogle Scholar
  27. Carney MWP, Chary TKN, Bottiglieri T, et al. Switch mechanism in affective illness and oral S-adenosyl methionine. British Journal of Psychiatry 150: 724–725, 1987PubMedCrossRefGoogle Scholar
  28. Carney MWP, Chary TKN, Bottiglieri T, Reynolds EH. The switch mechanism and the bipolar/unipolar dichotomy. British Journal of Psychiatry 154: 48–51, 1989PubMedCrossRefGoogle Scholar
  29. Carney MWP, Chary TKN, Laundy M, Bottiglieri T, Chanarin I, et al. Red cell folate concentrations in psychiatric patients. Journal of Affective Disorders 19: 207–213, 1990PubMedCrossRefGoogle Scholar
  30. Chanarin I. The megaloblastic anaemias, Blackwell, Oxford, 1979Google Scholar
  31. Chapuy P, Remet JC, Karlin R. Interet du dosage de la vitamine B12 et des folates. Revue de Geriatrie 2: 151–156, 1977Google Scholar
  32. Clayton PT, Smith I, Harding B, Hyland K, Leonard JV, et al. Subacute combined degeneration of the cord, dementia and parkinsonism due to an inborn error of folate metabolism. Journal of Neurology, Neurosurgery and Psychiatry 49: 920–927, 1986CrossRefGoogle Scholar
  33. Coppen A, Abou-Saleh MT. Plasma folate and affective morbidity during long term lithium therapy. British Journal of Psychiatry 141: 87–89, 1982PubMedCrossRefGoogle Scholar
  34. Coppen A, Chaudry S, Swade C. Folic acid enhances lithium prophylaxis. Journal of Affective Diseases 10: 9–13, 1986CrossRefGoogle Scholar
  35. Coppen A, Swade C, Jones SA, Armstrong RA, Blair JA, et al. Depression and tetrahydropbiopterin: the folate connection. Journal of Affective Disorders 16: 103–107, 1989PubMedCrossRefGoogle Scholar
  36. Crellin RF, Flynn TG, Laundy M, Toone BK, Reynolds EH, et al. Methylfolate as a monotherapy in depression. Presented at the Annual Meeting of Royal College of Psychiatrists, Dublin, July 24–27, 1992Google Scholar
  37. Edeh J, Toone BK. Antiepileptic therapy, folate deficiency and psychiatric morbidity: results of a survey in general practice. Epilepsia 26: 434–440, 1985PubMedCrossRefGoogle Scholar
  38. Friedel HA, Goa KL, Benfield P. S-Adenosyl-L-Methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 38: 389–416, 1989PubMedCrossRefGoogle Scholar
  39. Ghadirian AM, Ananth J, Engelsmann F. Folic acid deficiency and depression. Psychosomatics 21: 926–929, 1980PubMedGoogle Scholar
  40. Girdwood RH, Thomson AD, Williamson S. Folate status in the elderly. British Medical Journal 2: 670–672, 1967PubMedCrossRefGoogle Scholar
  41. Godfrey PSA, Toone BK, Carney MWP, Flynn TG, Bottiglieri T, et al. Enhancement of recovery from psychiatric illness by methyl folate. Lancet 336: 392–395, 1990PubMedCrossRefGoogle Scholar
  42. Goodwin JS, Goodwin JM, Garry PJ. Association between nutritional status and cognitive functioning in a healthy elderly population. Journal of the American Medical Association 249: 2917–2921, 1983PubMedCrossRefGoogle Scholar
  43. Gray GE, Leong GB. Serum folate levels in U.S. psychiatric inpatients. Journal of Clinical Psychiatry 47: 98–99, 1986PubMedGoogle Scholar
  44. Gündersen HJG. Serum folate in psychiatric patients under long term treatment with tricyclic neuroleptic drugs. Acta Psychiatrica Scandinavica 45: 133–136, 1969PubMedCrossRefGoogle Scholar
  45. Hallstrom T. Serum B12 and folate concentrations in mental patients. Acta Psychiatrica Scandinavica 45: 19–36, 1969PubMedCrossRefGoogle Scholar
  46. Hamon CBG, Blair JA, Barford PA. The effect of methyltetrahydrofolate on tetrhydrobiopterin metabolism. Journal of Mental Deficiency Research 30: 170–183, 1986Google Scholar
  47. Hommes OR, Hollinger JL, Jansen NJT, et al. Convulsant properties in folate compounds: some considerations and speculations. In Botez & Reynolds (Eds) Folic acid in neurology, psychiatry and internal medicine, pp. 285–316, Raven Press, New York, 1979Google Scholar
  48. Hunter R, Jones M, Jones TG, Matthews DM. Serum B12 and folate concentrations in mental patients. British Journal of Psychiatry 113: 1291–1295, 1967CrossRefGoogle Scholar
  49. Hunter R, Barnes J, Oakeley MF, Matthews DM. Toxicity of folic acid given in pharmacological doses to healthy volunteers. Lancet 1: 61–63, 1970PubMedCrossRefGoogle Scholar
  50. Hurdle ADF, Williams TCP. Folic acid deficiency in elderly patients admitted to hospital. British Medical Journal 2: 202–205, 1966PubMedCrossRefGoogle Scholar
  51. Hyland K, Smith I, Bottiglieri T, Perry J, Wendel U, et al. Demyelination and decreased S-adenosyl methionine in 5,10-methylenetetrahydrofolate reductase deficiency. Neurology 38: 459–462, 1988PubMedCrossRefGoogle Scholar
  52. Ibotson RN, Dilena BA, Horwood JM. Studies on deficiency and absorbtion of folates in patients on anticonvulsant drugs. Australasian Annals of Medicine 16: 144–150, 1967Google Scholar
  53. Jensen ON, Olesen OV. Folic acid concentrations in psychiatric patients. Acta Psychiatrica Scandinavica 45: 289–294, 1969PubMedCrossRefGoogle Scholar
  54. Kallstrorn B, Nylof R. Vitamin B12 and folic acid in psychiatric disorders. Acta Psychiatrica Scandinavica 43: 137–152, 1969CrossRefGoogle Scholar
  55. Kariks J, Perry SW. Folic acid deficiency in psychiatric patients. Medical Journal of Australia 1: 1192–1195, 1970PubMedGoogle Scholar
  56. Kaufman S. Regulatory properties of pterin-dependent hydroxylases: varitions on a theme. In Kaufman et al. (Eds) Function and regulation of monoamine enzymes, pp. 165–173, Macmillan, New York, 1981Google Scholar
  57. Kaufman S. Some metabolic relationships between biopterin and folate: implications for the ‘methyl trap hypothesis’. Neurochemistry Research 16: 1031–1036, 1991CrossRefGoogle Scholar
  58. Kay HEM, Knapton PJ, O’Sullivan JP, Wells DG, Harris RF, et al. Encephalopathy in acute leukaemia associated with methotrexate therapy. Archives of Disease in Childhood 47: 344–354, 1972PubMedCrossRefGoogle Scholar
  59. Korevaar WC, Geyer MA, Knapp S, Hsu LL, Mandell AJ. Regional distribution of 5 methyl-tetrahydrofolic acid in brain. Nature 245: 244–245, 1973CrossRefGoogle Scholar
  60. Krai VA, Solyom L, Enesco H, Ledwidge B. Relationship of vitamin B12 and folk acid to memory function. Biological psychiatry 2: 19–26, 1970Google Scholar
  61. Leaver EG, Elwes RDC, Williams A, Reynolds EH. Subacute combined degeneration of the cord due to folate deficiency: response to methylfolate treatment. Journal of Neurology, Neurosurgery and Psychiatry 49: 1203–1207, 1986CrossRefGoogle Scholar
  62. MRC Study Group. Prevention of neural tube defects: results of MRC Vitamin Research study. Lancet 338: 131–137, 1991CrossRefGoogle Scholar
  63. Niederweiser A. Inborn errors of pterin metabolism. In Botez & Reynolds (Eds) Folic acid in neurology, psychiatry and internal medicine, pp. 349–384, Raven Press, New York, 1979Google Scholar
  64. Passeri M, Cucinotta D, Abate G, Senin U, Ventura A, et al. Oral 5-methyltetrahydrofolic acid in senile organic mental disorders with depression: resutts of a double-blind multicenter study. Aging. Clinical and Experimental Research, in press, 1993Google Scholar
  65. Read AE, Gough AR, Pardoe JL, Nicholas A. Nutritional studies on the entrants to an old peoples home with particular reference to folic acid deficiency. British Medical Journal 2: 843–848, 1965PubMedCrossRefGoogle Scholar
  66. Reynolds EH. Effects of folic acid on the mental state and fit frequency of drug treated epileptic patients. Lancet 1: 1186–1188, 1967Google Scholar
  67. Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clinics in Haematology 5: 661–696, 1976PubMedGoogle Scholar
  68. Reynolds EH. Folic acid, vitamin B12 and the nervous system: historical aspects. In Botez & Reynolds (Eds) Folic acid in neurology, psychiatry and internal medicine, pp. 1–5, Raven Press, New York, 1979aGoogle Scholar
  69. Reynolds EH. Cerebrospinal fluid folate: clinical studies. In Botez & Reynolds (Eds) Folic acid in neurology psychiatry and internal medicine, pp. 195–203, Raven Press, New York, 1979bGoogle Scholar
  70. Reynolds EH. Folic acid and neuropsychiatry. Farmaci & Terapia 2: 163–168, 1985Google Scholar
  71. Reynolds EH. Interictal psychiatric disorders: neurochemical aspects. Advances in Neurology 55: 47–58, 1991PubMedGoogle Scholar
  72. Reynolds EH, Preece JM, Bailey J, Coppen A. Folate deficiency in depressive illness. British Journal of Psychiatry 117: 287–292, 1970PubMedGoogle Scholar
  73. Reynolds EH, Preece J, Johnson AL. Folate metabolism in epileptic and psychiatric patients. Journal of Neurology, Neurosurgery and Psychiatry 34: 726–732, 1971CrossRefGoogle Scholar
  74. Reynolds EH, Rothfield P, Pincus JH. Neurological disease associated with folate deficiency. British Medical Journal 2: 398–400, 1973PubMedCrossRefGoogle Scholar
  75. Reynolds EH, Stramentinoli G. Folic acid, S-adenosyl methionine and affective disorder. Psychological Medicine 13: 705–710, 1983.PubMedCrossRefGoogle Scholar
  76. Reynolds EH, Carney MWP, Toone BK. Methylation and mood. Lancet 2: 196–198, 1984PubMedCrossRefGoogle Scholar
  77. Robertson MM, Trimble MR. Depressive illness in patients with epilepsy: a review. Epilepsia 24 (Suppl.): 5109–5116, 1983CrossRefGoogle Scholar
  78. Rodin E, Schmaltz S. Folate levels in epileptic patients. In Advances in epileptology, XIVth Epilepsy International Symposium, pp.143–153, Raven Press, New York, 1983Google Scholar
  79. Rosenblatt DS. Inherited disorders of folate transport and metabolism. In Scriver et al. (Eds) The metabolic basis of inherited disease, 6th ed., pp. 693–735, McGraw, New York, 1989Google Scholar
  80. Roudier M, Hercberg S, Soustre Y, Galan P, Kadouche J, et al. Statut en fer et en folates d’une populations de sûjets âges vivant en hôpital gériatrique de long séjour. Cahiers de Nutrition et de Dietetique 19: 1927–1929, 1984Google Scholar
  81. Runcie J. Folate deficiency in the elderly. In Botez & Reynolds (Eds) Folic acid in neurology, psychiatry and internal medicine, pp. 497–499, Raven Press, New York, 1979Google Scholar
  82. Sapira JD, Tullis S. Mallaly R. Reversible dementia due to folate deficiency. Southern Medical Journal 68: 776–778, 1975PubMedCrossRefGoogle Scholar
  83. Schwartz SO, Kaplan SW, Armstrong BE. The long term evaluation of folic acid in the treatment of pernicious anaemia. Journal of Laboratory and Clinical Medicine 35: 894–898, 1950PubMedGoogle Scholar
  84. Shaw DM, MacSweeney DA, Johnson AL, O’Keefe R, Naidoo D, et al. Folate and amine metabolites in senile dementia: a combined trial and biochemical study. Psycholological Medicine 1: 166–171, 1971CrossRefGoogle Scholar
  85. Shaw DM, Tidmarsh SF, Thomas DE, Briscoe M, Dickerson JWT, et al. Senile dementia and nutrition. British Medical Journal 288: 792–793, 1984PubMedCrossRefGoogle Scholar
  86. Shorvon SD, Carney MWP, Chanarin I, Reynolds EH. The neuropsychiatry of megaloblastic anaemia. British Medical Journal 281: 1036–1042, 1980PubMedCrossRefGoogle Scholar
  87. Shulman R. A survey of Vitamin B12 deficiency in an elderly psychiatric population. British Journal of Psychiatry 113: 241–251, 1967PubMedCrossRefGoogle Scholar
  88. Sneath P, Chanarin I, Hodkinson HM, McPherson CK, Reynolds EH. Folate status in a geriatric population and its relation to dementia. Age and Ageing 2: 177–182, 1973PubMedCrossRefGoogle Scholar
  89. Sommer BR, Wolkowitz OM. RBC folic acid levels and cognitive performance in elderly patients: a preliminary report. Biological Psychiatry 24: 352–334, 1988PubMedCrossRefGoogle Scholar
  90. Spector R, Lorenzo AV. Folate transport in the central nervous system. American Journal of Physiology 229: 777–782, 1975PubMedGoogle Scholar
  91. Strachan RW, Henderson JG. Dementia and folate deficiciency. Quarterly Journal of Medicine 36: 189–204, 1967PubMedGoogle Scholar
  92. Thomas CS, Bottiglieri T, Edeh J, Carney MWP, Reynolds EH, et al. The influence of S-adenosyl methionine (SAMe) on prolactih in depressed patients. International Clinical Psychopharmacology 2: 97–103, 1987PubMedCrossRefGoogle Scholar
  93. Thornton WE, Thornton BP. Geriatric mental function and serum folate: a review and survey. Southern Medical Journal 70: 919–922, 1977PubMedCrossRefGoogle Scholar
  94. Thornton, WE, Thornton BP. Folic acid, mental function and dietary habits. Journal of Clinical Psychiatry 39: 315–322, 1978PubMedGoogle Scholar
  95. Trimble MR, Corbett JA, Donaldson D. Folic acid and mental symptoms in children with epilepsy. Journal of Neurology, Neurosurgery and Psychiatry 43: 1030–1034, 1980CrossRefGoogle Scholar
  96. Young SN, Ghadirian AM. Folic acid and psychopathology. Progress in Neuropsychopharmacology and Biological Psychiatry 13: 841–863, 1989CrossRefGoogle Scholar

Copyright information

© Adis International Limited 1993

Authors and Affiliations

  • R. Crellin
    • 1
  • T. Bottiglieri
    • 2
  • E. H. Reynolds
    • 3
  1. 1.Department of Adult PsychiatryQueen Elizabeth Psychiatric HospitalBirminghamEngland
  2. 2.Metabolic Disease CenterBaylor Research InstituteDallasUSA
  3. 3.Department of NeurologyInstitute of Psychiatry and King’s College School of Medicine and DentistryLondonEngland

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