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Comparison of Nimesulide and Diclofenac in the Prevention and Treatment of Painful Inflammatory Postoperative Complications of General Surgery

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Summary

In a double-blind study, 40 patients scheduled for saphenectomy or inguinal hernioplasty were randomly assigned to treatment with nimesulide (200mg 3 times daily) or diclofenac (100mg 3 times daily) administered rectally. Therapy with either drug resulted in significantly less pain, oedema and hyperaemia, and resolution of mild fever. No adverse reactions attributable to treatment were observed.

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Authors and Affiliations

  1. Servizio di Anestesia, Rianimazione e Terapia del Dolore, Ospedale di Abbiategrasso, 28081, Abbiategrasso (MI), Italy

    G. Ramella, V. Costagli, M. Vetere, C. Capra, G. Casella & A. Sogni

  2. Direzione Ricerche Cliniche Boehringer Mannheim Italia SpA, Milan, Italy

    I. Scaricabarozzi

Authors
  1. G. Ramella
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  2. V. Costagli
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  3. M. Vetere
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  4. C. Capra
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  5. G. Casella
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  6. A. Sogni
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  7. I. Scaricabarozzi
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Ramella, G., Costagli, V., Vetere, M. et al. Comparison of Nimesulide and Diclofenac in the Prevention and Treatment of Painful Inflammatory Postoperative Complications of General Surgery. Drugs 46 (Suppl 1), 159–161 (1993). https://doi.org/10.2165/00003495-199300461-00038

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  • DOI: https://doi.org/10.2165/00003495-199300461-00038

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