Summary
The clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) in asthmatic patients is limited by the possibility that these drugs may aggravate asthma by increasing the production of leukotrienes. Nimesulide, an NSAID with a weak inhibitory activity on prostaglandin synthetase, has been hypothesised to be safer than other NSAIDs in asthma. We have recently demonstrated in asthmatics who were allergic to the house dust mite that nimesulide neither alters the bronchial response to allergen nor aggravates the allergen-induced increase in airway responsiveness.
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References
Adams GK, Adkinson Jr NJ, Lichtenstein LM. Arachidonic acid metabolism and antigen-induced bronchospasm. Federation Proceedings 40: 1024, 1981
Brusasco V, Crimi E, Gianiorio P, Lantero S, Rossi GA. Allergen-induced increase in airway responsiveness and inflammation in mild asthma. Journal of Applied Physiology 69: 2209–2214, 1990
Capsoni F, Venegoni E, Minonzio F, Ongari AM, Maresca V, et al. Inhibition of neutrophils oxidative metabolism by nime-sulide. Agents and Actions 21: 121–129, 1987
De Lucia F, Bonavia M, Crimi E, Scaricabarozzi I, Brusasco V. Antiinflammatory-antioxidant treatment with a methane sulfonanilide in allergen-induced asthma. Annals of Allergy 66: 424–429, 1991
Durham SR, Carroll M, Walsh GM, Kay AB. Leucocyte activation in allergen-induced late-phase asthmatic reaction. New England Journal of Medicine 311: 1398–1402, 1984
Fairfax AJ. Inhibition of the late asthmatic response to house dust mite by non-steroidal anti-inflammatory drugs. Prostaglandins and Leucotrienes in Medicine 8: 239–248, 1982
Hargreave FE, Ramsdale EH, Kirby JG, O’Byrne PM. Asthma and the role of inflammation. European Journal of Respiratory Disease 69 (Suppl. 147): 16–21, 1986
Joubert JR, Shephard E, Mouton W, Van Zyk L, Viljoen I. Non-steroid anti-inflammatory drugs in asthma: dangerous or useful therapy? Allergy 40: 202–207, 1985
McDonald JR, Matthison DA, Stevenson DD. Aspirin intolerance in asthma. Journal of Allergy and Clinical Immunology 50: 198–207, 1972
Rufer C, Schillinger E, Böttcher I, Repenthin W, Herrmann Ch. Non-steroidal anti-inflammatories — XII. Mode of action of anti-inflammatory methane sulfonanilides. Biochemical Pharmacology 31: 3591–3596, 1982
Shephard EG, Malan L, Macfarlane CM, Mouton W, Joubert JR. Lung function and plasma levels of thromboxane B2, 6-keto-prostaglandin F1α and B-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. British Journal of Clinical Pharmacology 19: 459–470, 1985
Vigdahl RL, Tukey RH. Mechanism of action of novel anti-nflammatory drugs diflumidone and R-805. Biochemical Pharmacology 26: 307–311, 1977
Walker JL. The regulatory function of prostaglandins in the release of histamine and SRS-A from passively sensitized human lung tissue. In Bergstrom S, Bernhard S (Eds) Advances in the Biosciences. Braunschweig: Pergamon Press Vieweg, pp. 235–239, 1973
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Brusasco, V., Crimi, E. & Scaricabarozzi, I. Nimesulide Does Not Interfere with Airway Responsiveness in Allergic Asthma. Drugs 46 (Suppl 1), 121–123 (1993). https://doi.org/10.2165/00003495-199300461-00025
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DOI: https://doi.org/10.2165/00003495-199300461-00025