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The Epidemiology of Bacterial Resistance to Quinolones

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Summary

The new fluoroquinolones have been in use for nearly 10 years in the treatment of community-and nosocomially-acquired infections. Resistant clones may be selected during therapy and disseminate if favourable epidemiological conditions prevail. Resistance to the fluoroquinolones is still rare in common pathogens with 97 to 100% of strains remaining susceptible. Resistance has been reported in methicillin-susceptible Staphylococcus aureus, Campylobacter jejuni/coli, Salmonella, Shigella and Escherichia coli. Among nosocomial pathogens, the incidence of fluoroquinolone resistance varies between bacterial species, countries and periods of study, and is dependent on local epidemiological factors and antibiotic policies. The highest incidence of resistance is observed in Serratia and Acinetobacter spp., and particularly in methicillin-resistant S. aureus. Surveillance programmes are needed to follow up trends in resistance to the fluoroquinolones and their possible association with clinical failures.

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References

  • Aboukasm AG, Buu-Hoï AY, El Solh N, Morvan A, Acar JF. Epidemiological study of Staphylococcus aureus resistance to new quinolones in a university hospital. Journal of Hospital Infection 17: 25–33, 1991

    Article  PubMed  CAS  Google Scholar 

  • Acar J, Bergogne-Bérézin E, Chabbert Y, Cluzel R, Courvalin P, et al. Communiqué 1992 du Comité de l’antibiogramme de la Société Française de Microbiologie. Pathologie Biologie 40: 741–748, 1992

    Google Scholar 

  • Acar JF, Francoual S. The clinical problems of bacterial resistance to the new quinolones. Journal of Antimicrobial Chemotherapy 26 (Suppl. B): 207–213, 1990

    PubMed  Google Scholar 

  • Alos JI, Gómez-Garcés JL, Cogollos R, Amor E, Pérez-Rivilla A. Susceptibilities of ampicillin-resistant strains of Salmonella other than S. typhi to 10 antimicrobial agents. Antimicrobial Agents and Chemotherapy 36: 1794–1796, 1992

    CAS  Google Scholar 

  • Aubert G, Levy PP, Ros A, Meley R, Meley B, et al. Changes in the sensitivity of urinary pathogens to quinolones between 1987 and 1990 in France. European Journal of Clinical Microbiology and Infectious Diseases 11: 5–7, 1992

    Google Scholar 

  • Barry AL, Fuchs PC. Cross-resistance and cross-susceptibility between fluoroquinolone agents. European Journal of Clinical Microbiology and Infectious Diseases 10: 1013–1018, 1991

    Article  CAS  Google Scholar 

  • Clendennen TE, Echeverria P, Saengeur S, Kees ES, Boslego JW, et al. Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand. Antimicrobial Agents and Chemotherapy 36: 1682–1687, 1992

    Article  PubMed  CAS  Google Scholar 

  • Cooper B, Lawlor M. Pneumococcal bacteremia during ciprofloxacin therapy for pneumocoecal pneumoniae. American Journal of Medicine 87: 475, 1989

    Article  PubMed  CAS  Google Scholar 

  • Endtz HP, Ruijs GJ, Van Klingeren B, Jansen WH, Van der Reyden T, et al. Quinolone resistance in Campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine. Journal of Antimicrobial Chemotherapy 27: 199–208, 1991

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Rodriguez JA, Gomez-Garcia AC. Susceptibility of pathogenic microorganisms after 4–6 years of using new quinolones. Quinolones Bulletin 6: 15–17, 1990

    Google Scholar 

  • Gordon JJ, Kauffman CA. Superinfection with Streptococcus pneumoniae during therapy with ciprofloxacin. American Journal of Medicine 89: 383–384, 1990

    Article  PubMed  CAS  Google Scholar 

  • Grüneberg RN. Changes in the antibiotic sensitivities of urinary pathogens, 1971–1989. Journal of Antimicrobial Chemotherapy 26 (Suppl. F): 3–11, 1990

    PubMed  Google Scholar 

  • Harnett N, Brown S, Krishnan C. Emergence of quinolone resistance among clinical isolates of methicillin-resistant Staphylococcus aureus in Ontario, Canada. Antimicrobial Agents and Chemotherapy 35: 1911–1913, 1991

    Article  PubMed  CAS  Google Scholar 

  • Hirschl AM, Wolf D, Berger J, Rotter ML. In vitro susceptibility of Campylobacter jejuni and Campylobacter coli isolated in Austria to erythromycin and ciprofloxacin. Zentralblatt fur Bakteriologie 272: 443–447, 1990

    Article  PubMed  CAS  Google Scholar 

  • Jones RN, Relier LB, Rosati LA, Erwin ME, Sanchez ML, and the Ofloxacin Surveillance Group. Ofloxacin, anew broad-spectrum fluoroquinolone. Results from a multicenter, national comparative activity surveillance study. Diagnostic Microbiology and Infectious Disease 15: 425–434, 1992

    CAS  Google Scholar 

  • Kresken M, Wiedemann B. Development of resistance to nalidixic acid and the fluoroquinolones after the introduction of norfloxacin and ofloxacin. Antimicrobial Agents and Chemotherapy 32: 1285–1288, 1988

    Article  PubMed  CAS  Google Scholar 

  • Lee BL, Padula AM, Kimbrough RC, Jones SR, Chaisson RE, et al. Infectious complications with respiratory pathogens despite ciprofloxacin therapy. New England Journal of Medicine 325: 520–521, 1991

    Article  PubMed  CAS  Google Scholar 

  • Ling JM, Zhou G-M, Woo THS, French GL. Antimicrobial susceptibilities and β-lactamase production of Hong Kong isolates of gastroenteric salmonellae and Salmonella typhi. Journal of Antimicrobial Chemotherapy 28: 877–885, 1991

    Article  PubMed  CAS  Google Scholar 

  • Neal TJ, O’Donoghue MAT, Ridgway EJ, Allen KD. In-vitro activity of ten antimicrobial agents against penicillin-resistant Streptococcus pneumoniae. Journal of Antimicrobial Chemotherapy 30: 39–46, 1992

    Article  PubMed  CAS  Google Scholar 

  • Olsson-Liljequist B, Möllby R. In vitro activity of norfloxacin and other antibacterial agents against gastrointestinal pathogens isolated in Sweden. APMIS 98: 150–155, 1990

    Article  PubMed  CAS  Google Scholar 

  • Putnam SD, Lavin BS, Stone JR, Oldfield III EC, Hooper DG. Evaluation of the standardized disk diffusion and agar dilution antibiotic susceptibility test methods by using strains of Neisseria gonorrhoeae from the United States and Southeast Asia. Journal of Clinical Microbiology 30: 974–980, 1992

    PubMed  CAS  Google Scholar 

  • Rautelin H, Renkonen O-V, Kosunen TU. Emergence of fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli in subjects from Finland. Antimicrobial Agents and Chemotherapy 35: 2065–2069, 1991

    Article  PubMed  CAS  Google Scholar 

  • Raviglione MC, Boyle JF, Mariuz P, Pablos-Mendez A, Cortes H, et al. Ciprofloxacin-resistant methicillin-resistant Staphylococcus aureus in an acute-care hospital. Antimicrobial Agents and Chemotherapy 34: 2050–2054, 1990

    Article  PubMed  CAS  Google Scholar 

  • Reina J, Alomar P. Fluoroquinolone-resistance in thermophilie Campylobacter spp. isolated from stools of Spanish patients. Lancet 2: 186, 1990

    Google Scholar 

  • Schaberg DR, Dillon WI, Terpenning MS, Robinson KA, Bradley SF, et al. Increasing resistance of enterococci to ciprofloxacin. Antimicrobial Agents and Chemotherapy 36: 2533–2535, 1992

    Article  PubMed  CAS  Google Scholar 

  • Schaefler S. Methicillin-resistant strains of Staphylococcus aureus resistant to quinolones. Journal of Clinical Microbiology 27: 335–336, 1989

    PubMed  CAS  Google Scholar 

  • Shalit I, Berger SA, Gorea A, Frimerman H. Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital. Antimicrobial Agents and Chemotherapy 33: 593–594, 1989

    Article  PubMed  CAS  Google Scholar 

  • Soussy C-J. L’évolution de l’écologie bactérienne hospitalière menace-t-elle le gain thérapeutique des fluoroquinolones au même titre que celui des autres antibactériens? La Lettre de L’Infectiologue Hors série: 6–7, 1991

  • Voogd CE, Schot CS, Van Leeuwen WJ, Van Klingeren B. Monitoring of antibiotic resistance in Shigellae isolated in the Netherlands 1984–1989. European Journal of Clinical Microbiology and Infectious Diseases 11: 164–167, 1992

    Article  CAS  Google Scholar 

  • Wolfson JS, Hooper DC. Fluoroquinolone antimicrobial agents. Clinical Microbiology Reviews 2: 378–424, 1989

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Microbiologie Médicale, Hôpital Saint-Joseph, 7 rue Pierre Larousse, 75674, Paris, Cédex 14, France

    J. F. Acar & F. W. Goldstein

  2. Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

    T. F. O’Brien

  3. Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA

    R. N. Jones

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  1. J. F. Acar
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  2. T. F. O’Brien
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  3. F. W. Goldstein
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  4. R. N. Jones
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Acar, J.F., O’Brien, T.F., Goldstein, F.W. et al. The Epidemiology of Bacterial Resistance to Quinolones. Drugs 45 (Suppl 3), 24–28 (1993). https://doi.org/10.2165/00003495-199300453-00006

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