, Volume 44, Issue 2, pp 165–169 | Cite as


Depressants or Antidepressants?
  • John W. G. Tiller
  • Isaac Schweitzer
Leading Article


Amitriptyline Panic Disorder Alprazolam Moclobemide Agoraphobia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd ed., revised, DSM-III-R, American Psychiatric Association, Washington, DC, 1987Google Scholar
  2. Arana GW, Pearlman C, Shader RI. Alprazolam-induced mania: two clinical cases. American Journal of Psychiatry 142: 368–369, 1985PubMedGoogle Scholar
  3. Baldessarini RJ. Drugs and the treatment of psychiatric disorders. In Gilman AG et al. (Eds) Goodman & Gilman’s The pharmacological basis of therapeutics, 7th ed., pp. 387–445, Macmillan, New York, 1985Google Scholar
  4. Breier A, Cherney DS, Heninger GR. Agoraphobia with panic attacks: development, diagnostic stability and course of illness. Archives of General Psychiatry 43: 1029–1036, 1986PubMedCrossRefGoogle Scholar
  5. Committee on the Review of Medicines. Systematic review of the benzodiazepines. British Medical Journal 280: 910–912, 1980CrossRefGoogle Scholar
  6. Covi L, Lipman RS, Pattison JH, Derogatis LR, Uhlenhuth EH. Length of treatment with anxiòlytic sedatives and response to the sudden withdrawal. Acta Psychiatrica Scandinavica 49: 51–64, 1973PubMedCrossRefGoogle Scholar
  7. Fabre LF, McLendon DM. A double-blind study comparing the efficacy and safety of alprazolam with imipramine and placebo in primary depression. Current Therapeutic Research 27: 478–482, 1980Google Scholar
  8. Feighner JP, Aden GC, Fabre LF, et al. Comparison of alprazolam, imipramine, and placebo in the treatment of depression. Journal of the American Medical Association 249: 3057–3064, 1983PubMedCrossRefGoogle Scholar
  9. Fontaine R, Chouinard G, Annabele L. Rebound anxiety in anxious patients after abrupt withdrawal of benzodiazepine treatment. American Journal of Psychiatry 141: 848–852, 1984PubMedGoogle Scholar
  10. Greenblatt DJ, Shader RI. Benzodiazepines in clinical practice, New York, Raven Press, 1974Google Scholar
  11. Hall RCW, Joffe JR. Aberrant response to diazepam: a new syndrome. American Journal of Psychiatry 129: 114–118, 1972Google Scholar
  12. Kahn JP, Stevenson E, Topol P, Klein DF. Agitated depression, alprazolam, and panic anxiety. American Journal of Psychiatry 143: 1172–1173, 1986PubMedGoogle Scholar
  13. Klerman GL. Overview of the cross-national collaborative panic study. Archives of General Psychiatry, 45: 407–412, 1988PubMedCrossRefGoogle Scholar
  14. Lehmann HE. Affective disorders: clinical features. In Kaplan & Sadock (Eds) Comprehensive textbook of psychiatry - IV, table 18.5-12, pp. 802, Williams & Wilkins, Baltimore, 1985Google Scholar
  15. Lennane KJ. Treatment of benzodiazepine dependence. Medical Journal of Australia 144: 594–597, 1986PubMedGoogle Scholar
  16. Lesser IM, Rubin RT, Pecknold JC, Rifkin A, Swinson RP. Secondary depression in panic disorder and agoraphobia: frequency, severity and response to treatment. Archives of General Psychiatry 45: 437–443, 1988PubMedCrossRefGoogle Scholar
  17. Lydiard RB, Larara MT, Ballenger JC, Howell EF. Emergence of depressive symptoms in patients receiving alprazolam for panic disorder. American Journal of Psychiatry 144: 664–665, 1987PubMedGoogle Scholar
  18. Mayerhoff D, Vital-Herne J, Lesser M. Alprazolam inducted manic reaction. New York State Journal of Medicine 320: 6, 1986Google Scholar
  19. Noyes R, Crowe RR, Harris EL, McChesney C, Hamra G. Medicine 320. Relationship of panic disorder and agoraphobia: a family study. Archives of General Psychiatry 43: 227–233, 1986Google Scholar
  20. Noyes R, DuPont RL, Pecknold JC, Rifkin A, Rubin RT, et al. Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. Archives of General Psychiatry 45: 423–428, 1988PubMedCrossRefGoogle Scholar
  21. Owen RT, Tyrer P. Benzodiazepine dependence: a review of the evidence. Drugs 25: 385–398, 1983PubMedCrossRefGoogle Scholar
  22. Pettinati HM, Stevenson SM, Willis KM, Robin SE. Evidence of a less improvement in depression in patients taking benzodiazepines during unilateral ECT. American Journal of Psychiatry 147: 109–135, 1990Google Scholar
  23. Petursson H, Lader MH. Withdrawal from long-term benzodiazepine treatment. British Medical Journal 283: 543–645, 1981CrossRefGoogle Scholar
  24. Pies R. Alprazolam for panic disorder and depression. American Journal of Psychiatry 140: 640, 1983PubMedGoogle Scholar
  25. Raskin A, Schulterbrandt JG, Reatig N, et al. Depression subtypes in response to phenelzine, diazepam and a placebo. Archives of General Psychiatry 30: 66–75, 1974PubMedCrossRefGoogle Scholar
  26. Remick RA. Alprazolam-induced manic switch. Journal of Clinical Psychiatry 46: 406–407, 1985PubMedGoogle Scholar
  27. Rickels K, Cohen DO, Csanalosi I, et al. Alprazolam and imipramine in depressed outpatients: a controlled study. Current Therapeutic Research 32: 157–164, 1982Google Scholar
  28. Rickels K, Feighner JP, Smith WT. Alprazolam, amitriptyline, doxepin and placebo in the treatment of depression. Archives of General Psychiatry 42: 134–141, 1985PubMedCrossRefGoogle Scholar
  29. Rush AJ, Erman NK, Schlesser MA, Roffwarg HP, Vasavada N, et al. Alprazolam vs amitriptyline in depressions with reduced REM latencies. Archives of General Psychiatry 42: 1152–1158, 1985CrossRefGoogle Scholar
  30. Ryan HF, Merrill FB, Scott GE, Krebs R, Thompson BL. Increase in suicidal thoughts and tendencies: association with diazepam therapy. Journal of the American Psychiatric Association 203: 135–137, 1968Google Scholar
  31. Schatzberg AF, Cole JO. Benzodiazepines in depressive disorders. Archives of General Psychiatry 35: 1359–1365, 1978PubMedCrossRefGoogle Scholar
  32. Sheehan DV, Ballenger J, Jacobson G. Relative efficacy of monoamine oxidase inhibitors and tricyclic antidepressants in the treatment of endogenous anxiety. In Klein DF & Rabkin JB (Eds) Anxiety: new research and changing concepts, pp. 44–67, New York, Raven Press, 1981Google Scholar
  33. Smith A, Rawlins MD. Community clinics and clinical pharmacology: benzodiazepines. British Medical Journal 2: 447, 1977PubMedCrossRefGoogle Scholar
  34. Thornbury WC. Alprazolam-induced depression. Pharmacology and Therapeutics 15: 1173, 1990Google Scholar
  35. Tiller JWG, Schweitzer I, Maguire KP, Davies BM. Is diazepam an antidepressant? British Journal of Psychiatry 155: 483–489, 1989PubMedCrossRefGoogle Scholar
  36. Van Valkenburg C, Akiskal AGS, Puzantian V, Rosenthal T. Anxious depressions: clinical, family history and naturalistic outcome. Comparisons with panic and major depressive disorders. Journal of Affective Disorders 6: 67–82, 1984Google Scholar

Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • John W. G. Tiller
    • 1
  • Isaac Schweitzer
    • 1
  1. 1.Department of Psychiatry, University of Melbourne, Clinical Sciences BuildingThe Royal Melbourne HospitalMelbourneAustralia

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