Self-Administration in the Pharmacological Treatment of Impotence
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Recent innovative research into the physiology and pharmacology of erection and the introduction of intracavernous injection of vasoactive agents have revolutionised our approach to the diagnosis and treatment of impotence. A thorough understanding of the rationale, indications, precautions and potential complications of intracavernous self-injection is essential for successful management.
The commonly used drugs for injection are papaverine, either alone or in combination with phentolamine, and alprostadil (prostaglandin E1). The major adverse effects include priapism, prolonged erection, and fibrosis of the erectile tissue. With the proper technique and appropriate dosage, this is a safe, minimally invasive, and highly effective treatment.
KeywordsImpotence Papaverine Phentolamine Priapism Alprostadil
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- Keogh EJ, Watters GR, Earle CM, Carati CJ, Wisniewski ZS, et al. Treatment of impotence by intrapenile injections. A comparison of papaverine and phentolamine: a double-blind, crossover trial. Journal of Urology 142: 726–728, 1989Google Scholar