Drugs

, Volume 40, Supplement 4, pp 45–47 | Cite as

Aggravation of the Severity of the Clonidine Withdrawal Syndrome in Conscious Rats by β2-Adrenoceptor Antagonists

  • Fokke A. M. Jonkman
  • Pieter A. van Zwieten
Short Communication Poster Presentation
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Keywords

Clonidine Metoprolol Salbutamol Guanfacine Adrenoceptor Antagonist 

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References

  1. Atkinson J, Sonnay M, Boillat N. Changes in central monoaminergic function during chronic treatment with clonidine in the spontaneously hypertensive rat. European Journal of Pharmacology 106: 613–617, 1985CrossRefGoogle Scholar
  2. Brodde O-E, Anlauf M, Graber H, Bock KD. In vitro and in vivo downregulation of human platelets α2-adrenoceptors. European Journal of Clinical Pharmacology 23: 403–409, 1982PubMedCrossRefGoogle Scholar
  3. Collier HOJ, Cutberth NJ, Francis DL. Clonidine dependence in the guinea-pig isolated ileum. British Journal of Pharmacology 73: 443–453, 1981PubMedCrossRefGoogle Scholar
  4. Engberg G, Elam M, Svensson T. Clonidine withdrawal: activation of brain noradrenergic neurons with specifically reduced α2-receptor sensitivity. Life Sciences 30: 235–243, 1982PubMedCrossRefGoogle Scholar
  5. Ishii K, Kato R. Development of tolerance to alpha-2-adrenergic agonists in the vascular system of the rat after chronic treatment with clonidine. Journal of Pharmacology and Experimental Therapeutics 231: 685–691, 1984PubMedGoogle Scholar
  6. Ishii K, Yamamoto S, Kato R. Development of clonidine-tolerance in the rat vas deferens: cross-tolerance to other presynaptic inhibitory agents. Life Sciences 30: 285–292, 1982PubMedCrossRefGoogle Scholar
  7. Jonkman FAM, Man PW, Thoolen MJMC, van Zwieten PA. Location of the clonidine withdrawal tachycardia in rats. Journal of Pharmacy and Pharmacology 37: 580–582, 1985PubMedCrossRefGoogle Scholar
  8. Jonkman FAM, Thoolen MJMC, Wilffert B, de Jonge A, Timmermans PBMWM, et al. Effect of salbutamol and the PDE-inhibitor RA 642 on the clonidine withdrawal syndrome in rats. Journal of Autonomic Pharmacology 4: 199–206, 1984PubMedCrossRefGoogle Scholar
  9. Thoolen MJMC, Hendriks JCA, Timmermans PBMWM, van Zwieten PA. Precipitation by yohimbine of the withdrawal syndromes of clonidine, guanfacine and methyldopa in the spontaneously hypertensive rat. Journal of Cardiovascular Pharmacology 5: 224–228, 1983PubMedCrossRefGoogle Scholar
  10. Thoolen MJMC, Timmermans PBMWM, van Zwieten PA. Withdrawal syndrome after continuous infusion of clonidine in normotensive rats. Journal of Pharmacy and Pharmacology 33: 232–235, 1981PubMedCrossRefGoogle Scholar

Copyright information

© Adis Press Limited 1990

Authors and Affiliations

  • Fokke A. M. Jonkman
    • 1
  • Pieter A. van Zwieten
    • 1
  1. 1.Departments of Pharmacotherapy and Cardiology, Academic Medical CentreUniversity of AmsterdamAZ AmsterdamThe Netherlands

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