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Drugs

, Volume 40, Supplement 2, pp 30–32 | Cite as

Double-Blind Multicentre Isradipine Dose-Confirmation Study in Pakistan

  • S. M. Rab
  • Mukhtar Azeem Mirza
  • Masood Hameed Khan
  • Abdus Samad
  • Mansoor Ahmed
Short Communication Section 3: Future Clinical Trends

Conclusions

Isradipine 2.5mg twice daily was more effective than the 1.25mg twice daily dose in achieving normalisation of blood pressure and overall response. Larger reductions in blood pressure occurred sooner after starting isradipine 2.5mg twice daily than after the 1.25mg twice daily dose. Thus, this study confirms the results of European and American studies. Isradipine 2.5mg twice daily appears to be the optimal dosage for Pakistani patients with hypertension.

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References

  1. British Isradipine Hypertension Group. Evaluation of the safety and efficacy of isradipine in elderly patients with essential hypertension. American Journal of Medicine 86(Suppl. 4A): 110–114, 1989Google Scholar
  2. Simonsen K, Sundstedt CD. Dose-response relationship and incidence of adverse drug reactions with isradipine in patients with essential hypertension. American Journal of Medicine 86(Suppl. 4A): 91–93, 1989PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1990

Authors and Affiliations

  • S. M. Rab
    • 1
  • Mukhtar Azeem Mirza
    • 2
  • Masood Hameed Khan
    • 2
  • Abdus Samad
    • 3
  • Mansoor Ahmed
    • 4
  1. 1.Department of MedicineJinnah Postgraduate Medical CentreKarachiWest Pakistan
  2. 2.Department of MedicineDow Medical CollegeKarachiWest Pakistan
  3. 3.National Institute of Cardiovascular DiseasesKarachiWest Pakistan
  4. 4.Department of CardiologyLiaquat National HospitalKarachiWest Pakistan

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