Acute Upper Gastrointestinal Bleeding
The treatment of acute upper gastrointestinal bleeding is becoming more dependent upon early diagnosis. For the majority of patients whose bleeding has stopped when they come to the physician’s attention, treatment for peptic disorders remains the mainstay of therapy. For patients who present to the physician actively bleeding, early intervention with endoscopic therapeutic techniques probably will be the most beneficial. Currently available pharmacotherapeutic agents are of limited value in this situation. Further studies to prove and confirm the efficacy of the various techniques need to be carried out.
KeywordsCimetidine Vasopressin Gastrointestinal Bleeding Tranexamic Acid Sucralfate
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- Gandhii GM. Intraperitoneal and intragastric norepinephrine instillation in massive gastrointestinal bleeding: clinical study. American Journal of Gastroenterology 76: 42–48, 1976Google Scholar
- Kittang E, Aadland E, Oyen D, et al. Effect of peroral antacid treatment in patients with acute upper gastrointestinal haemorrhage: a randomized controlled trial. Scandinavian Journal of Gastroenterology 75 (Suppl.): 190–192, 1982Google Scholar
- Londong W, Hasford J, Sander R. Prevention of recurrent bleeding from gastrointestinal ulcers by combined application of cimetidine and pirenzepine: a double-blind, randomized multicenter trial. In Dotevall G. (Ed.) Advances in gastroenterology with the selective antimuscarinic compound pirenzepine, pp. 152–153, Excerpta Medica, Amsterdam, 1982Google Scholar
- Marshall M, Bird T. Blood loss and replacement. Edward Arnold, London, 1983Google Scholar
- Raskin JB, Camara DS, Levine K. Effect of 15(R)-15-methyl prostaglandin E2on acute upper gastrointestinal hemorrhage. Abstract. Gastroenterology 88: 1550, 1985Google Scholar
- Silverstein FE, Gilbert DA, Tedesco FJ, et al. The National ASGE survey on upper gastrointestinal bleeding. II. Clinical prognostic factors. Gastrointestinal Endoscopy 27: 80–93, 1981Google Scholar