Summary
Nedocromil sodium inhibited the increase in eosinophil activation (measured by IgG- and complement-dependent cytotoxicity assays) induced by platelet activating factor (PAF). Inhibition of the upregulation in eosinophil effector function by nedocromil sodium was dose-dependent (optimal at 10− 7 mol/L) and paralleled that produced by a specific PAF antagonist, BN 52021. In addition, preliminary data suggest that nedocromil sodium can inhibit the increase in IgG-dependent release of LTC4 from human eosinophils after stimulation with the synthetic tripeptide, formyl-methionyl-leucyl-phenylalanine (fMLP). These data support our previous hypothesis that part of the mode of action of nedocromil sodium may be due to its ability to directly block the chemotactic factor-induced enhancement of inflammatory cell activity.
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Moqbel, R., Cromwell, O. & Kay, A. The Effect of Nedocromil Sodium on Human Eosinophil Activation. Drugs 37 (Suppl 1), 19–22 (1989). https://doi.org/10.2165/00003495-198900371-00005
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DOI: https://doi.org/10.2165/00003495-198900371-00005