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Sulbactam/Ampicillin in the Treatment of Lower Respiratory Infections

  • Section 3: Clinical Profile of Sulbactam/Ampicillin
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Summary

The increasing number of β- lactam antibiotic- resistant infections has led to the development of an alternative treatment: the combination of a β- lactam antibiotic with an irreversible, suicide- type, β- lactamase inhibitor. Such a combination, sulbactam/ampicillin, was used in clinical trials at 4 European and 1 American centres to treat severely ill patients with lower respiratory tract infections including bronchiectasis, pneumonia and purulent tracheobronchitis.

The sulbactam/ampicillin combination was assessed for safety, efficacy and tolerance in a total of 91 patients. Investigators from all 5 centres reported satisfactory bacteriological and clinical results. The combination agent either cured or improved the condition of virtually all patients who were evaluated. The few side effects reported mainly involved pain at the injection site.

A review of these studies indicates that therapy with sulbactam/ampicillin effectively treats lower respiratory tract infections in severely ill patients without causing serious adverse reactions.

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References

  • Acar JF, Goldstein FW, Kitzis MD, Eyquem VIT. Resistance pattern of anaerobic bacteria isolated in a general hospital during a two-year period. Journal of Antimicrobial Chemotherapy 8 (Suppl. 1): 9–16, 1981

    Article  PubMed  CAS  Google Scholar 

  • Bush K, Sykes RB. β-Lactamase inhibitors in perspective. Journal of Antimicrobial Chemotherapy 11: 97–107, 1983

    Article  PubMed  CAS  Google Scholar 

  • Causse GY. Worldwide microbial resistance to antimicrobial agents. Sexually Transmitted Diseases 11: 333–335, 1984

    Article  PubMed  CAS  Google Scholar 

  • English AR, Retsema JA, Girard AE, et al. CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterisation. Antimi-crobial Agents and Chemotherapy 14: 414–419, 1978

    Article  CAS  Google Scholar 

  • Greenwood D, Eley A. In-vitro evaluation of sulbactam. a penicillanic acid sulphone with β-lactamase inhibitory properties. Journal of Antimicrobial Chemotherapy 10: 117–123, 1982

    Article  PubMed  CAS  Google Scholar 

  • Neu HC. The emergence of bacterial resistance and its influence on empiric therapy. Reviews of Infectious Diseases 5 (Suppl.): S9–S20, 1983

    Article  PubMed  Google Scholar 

  • Retsema JA, English AR, Girard AE. Sulbactam and ampicillin: synergistic antibacterial activity against hospital isolates of Enterobacteriaceae. melhicillin-resistant Staphylococcus, and anaerobes. Proceedings of the 13th International Congress of Chemotherapy, Vienna. Aug 28–Sep 2, 1983. Abstract, pp. 23/1-23/5

  • Slack R. Review of bacterial resistance — a challenge to the treatment of urinary infection. Journal of Antimicrobial Chemotherapy 13 (Suppl. B): 1–7, 1984

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Staten Island Hospital and Downstate Medical Center, New York, New York, USA

    M. A. Castellano (Director, Pulmonary Service, Assistant Clinical Professor of Medicine)

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  1. M. A. Castellano
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Castellano, M.A. Sulbactam/Ampicillin in the Treatment of Lower Respiratory Infections. Drugs 35 (Suppl 7), 53–56 (1988). https://doi.org/10.2165/00003495-198800357-00013

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  • DOI: https://doi.org/10.2165/00003495-198800357-00013

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