Drugs

, Volume 35, Supplement 1, pp 68–71 | Cite as

The Effect of Tiaprofenic Acid on Uric Acid Excretion in Man

  • L. Sinigaglia
  • S. Zeni
  • F. Solazzi
  • G. Di Minno
  • S. Longatti
Section 3: Clinical Studies
  • 7 Downloads

Summary

The uricosuric effect of tiaprofenic acid was evaluated in a group of normouricaemic inpatients with various rheumatic disorders. Six patients aged 26 to 60 years were maintained on a standardised low-purine diet and, after a washout period of 72 hours, tiaprofenic acid was administered in 3 oral doses of 300mg 12-hourly. A normal renal function, as assessed by serum creatinine and creatinine clearance determinations, was considered mandatory for entry into the study.

The following parameters were evaluated before and after treatment: haematological values, blood urea nitrogen (BUN), serum and urinary creatinine concentrations, serum uric acid concentration and the fractional excretion rate of uric acid. Our preliminary results showed a substantial increase of urinary uric acid excretion in the samples collected after treatment, especially in the first 4 hours.

Keywords

Uric Acid Blood Urea Nitrogen Tiaprofenic Acid Oxaprozin Uric Acid Excretion 

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References

  1. Berlin D, Pottier J, Raynaud JP. Pharmacocinétique de l’acide tiaprofénique. Journal de Pharmacologie, 6: 1:106, 1975Google Scholar
  2. Daymond TJ. Simultaneous bioavailability of tiaprofenic acid in serum and synovial fluid in patients with rheumatoid arthritis. Rheumatology 7: 188–193, Karger, Basel, 1982Google Scholar
  3. Goldfarb S, Walker BR, Agnus ZS. The uricosuric effect of oxaprozin in humans. Journal of Clinical Pharmacology 25: 144–148, 1985PubMedGoogle Scholar
  4. Guidi G, Sinigaglia L, Ranza R, Marchesoni A, Barzaghi G, et al. Effects of tiaprofenic acid on serum and synovial levels of thromboxane B in patients with rheumatic disease — a preliminary report. In Berry et al. (Eds) Tiaprofenic acid, pp. 105–114 Excerpta Medica, Amsterdam 1985.Google Scholar
  5. Gutman AB. Uricosuric drugs, with special reference to probenecid and sulfinpyrazone. Advances in Pharmacology 4: 91–142, 1966PubMedCrossRefGoogle Scholar
  6. Scott S. Tiaprofenic acid pharmacology and pharmacokinetics. South African Medical Journal (Suppl.): 20–22, 1983Google Scholar
  7. Yu TF, Gutman AB. Study of the paradoxical effects of salicylate in low, intermediate and high dosage on the renal mechanisms for urate excretion in man. Journal of Clinical Investigation 38: 1298–1315, 1959PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press Limited 1988

Authors and Affiliations

  • L. Sinigaglia
    • 1
  • S. Zeni
    • 1
  • F. Solazzi
    • 1
  • G. Di Minno
    • 2
  • S. Longatti
    • 3
  1. 1.Department of Rheumatology‘Gaetano Pini’ HospitalMilanItaly
  2. 2.Department of internal MedicineUniversity of NaplesNaplesItaly
  3. 3.Medical DepartmentRoussel MaestrettiMilanItaly

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