The Effect of Tiaprofenic Acid on Uric Acid Excretion in Man
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The uricosuric effect of tiaprofenic acid was evaluated in a group of normouricaemic inpatients with various rheumatic disorders. Six patients aged 26 to 60 years were maintained on a standardised low-purine diet and, after a washout period of 72 hours, tiaprofenic acid was administered in 3 oral doses of 300mg 12-hourly. A normal renal function, as assessed by serum creatinine and creatinine clearance determinations, was considered mandatory for entry into the study.
The following parameters were evaluated before and after treatment: haematological values, blood urea nitrogen (BUN), serum and urinary creatinine concentrations, serum uric acid concentration and the fractional excretion rate of uric acid. Our preliminary results showed a substantial increase of urinary uric acid excretion in the samples collected after treatment, especially in the first 4 hours.
KeywordsUric Acid Blood Urea Nitrogen Tiaprofenic Acid Oxaprozin Uric Acid Excretion
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