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Drugs

, Volume 34, Supplement 3, pp 28–29 | Cite as

Pharmacokinetics and Haemodynamics of Felodipine as Monotherapy in Hypertensive Patients

  • Boo Edgar
  • P. Collste
  • K. Haglund
  • C. G. Regårdh
Short Communication Section 1: Pharmacology and Human Pharmacokinetics of Felodipine: Poster Presentations

Conclusions

The pharmacokinetic profile of felodipine in patients with hypertension does not differ significantly from that observed previously in healthy volunteers. Similarly, the pharmacokinetics are apparently unaffected by repeated administration. The reductions in systemic blood pressure appear to be correlated to plasma felodipine concentrations and are maintained during long term administration, despite a tachyphylaxis to the unwanted initial tachycardia seen with felodipine. Therefore, felodipine would seem to provide a suitable alternative to conventional therapy in the treatment of mild to moderate hypertension.

Keywords

Oral Dose Felodipine Intravenous Dose Systemic Blood Pressure Moderate Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

  1. Edgar B, Regårdh CG, Lundborg P, Romare S, Nyberg G, et al. Pharmacokinetic and pharmacodynamic studies of felodipine in healthy subjects after various single oral and intravenous doses. Biopharmaceutics and Drug Disposition 8: 235–248, 1987CrossRefGoogle Scholar

Copyright information

© ADIS Press Limited 1987

Authors and Affiliations

  • Boo Edgar
    • 1
  • P. Collste
    • 2
  • K. Haglund
    • 2
  • C. G. Regårdh
    • 1
  1. 1.Department of Cardiovascular Clinical PharmacologyAB HässleMölndalSweden
  2. 2.Department of MedicineHuddinge HospitalHuddingeSweden

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