The Possible Role of Quinolones in Yersiniosis
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The in vitro susceptibility of 135 strains of Yersinia enterocolitica was tested by agar dilution. About 85% of the strains were susceptible to trimethoprim (1 mg/L), tetracycline (4 mg/L), chloramphenicol (4 mg/L) and cefuroxime (8 mg/L); 90 to 100% to piperacillin (16 mg/L), cefotaxime (8 mg/L) and gentamicin (1 mg/L); 100% to ciprofloxacin (≤ 0.016 mg/L), ofloxacin (0.06 mg/L) and pefloxacin (0.12 mg/L).
The outcome of 88 patients, treated for various forms of yersiniosis, showed 15% failure for trimethoprim or co-trimoxazole and tetracycline and 70% failure for cephalosporins and aminoglycoside-β-lactam combinations.
Four patients were successfully treated with ciprofloxacin 500mg orally or 300mg intravenously administered twice daily for up to 6 weeks.
KeywordsOfloxacin Quinolones Trimethoprim Cefuroxime Piperacillin
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