, Volume 33, Supplement 4, pp 96–99 | Cite as

Buccal versus Sublingual Glyceryl Trinitrate Administration in the Treatment of Angina Pectoris

A Swedish Multicentre Study
  • Lars Rydén
Section 4: Nitrates in Ischaemic Heart Disease With Special Reference to Stable Angina


126 patients with chronic exercise-induced angina, who were accustomed to the use of sublingual glyceryl trinitrate, were entered into a multicentre 2-week crossover comparison of sublingual (Nitromex) and buccal (Suscard®) formulations of glyceryl trinitrate. Before randomisation the patients underwent a training period when doses of the buccal formulation were individualised. There were 31% fewer attacks with the buccal formulation, and more patients reported higher physical activity on the buccal compared with the sublingual formulation (30% vs 16%). The buccal formulation was also more effective when glyceryl trinitrate was used prophylactically to prevent expected attacks, being effective in 74% of attempts compared with 66% for the sublingual formulation (p<0.05). More patients preferred the buccal route of administration for prophylactic use (81% vs 4%, p<0.05). Similarly, when asked to select which they would use in future, 65% of patients preferred the buccal formulation (p<0.05), 19% preferred sublingual glyceryl trinitrate, and 16% did not express any preference.


Angina Pectoris High Physical Activity Anginal Attack Sublingual Glyceryl Trinitrate Sublingual Tablet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abrams J. Nitroglycerin and long-acting nitrates in clinical practice. American Journal of Medicine 74: 85–94, 1983PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press Limited 1987

Authors and Affiliations

  • Lars Rydén
    • 1
  1. 1.Department of CardiologyKärnsjukhusetSkövdeSweden

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