Evaluation of the Efficacy and Safety of Anisoylated Plasminogen Streptokinase Activator Complex in Early Myocardial Infarction
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In the 15 patients receiving a 20U dose of APSAC administered intravenously, recanalisation was effected in 11 (73%). These results compare favourably with those reported for intravenous tissue plasminogen activator and intracoronary streptokinase. Use of APSAC in this dose was associated with the development of a systemic lytic state in 12 of the 15 patients studied. Apart from a hypotensive reaction in 3 patients, no major adverse reactions attributable to APSAC were observed. Therefore, APSAC in a dose of 20U administered intravenously is safe and effective in the management of patients with early myocardial infarction. Successful coronary thrombolysis was always associated with the development of a systemic lytic state. This did not result in significant haemorrhagic complications in this small number of patients.
KeywordsStreptokinase Angiographic Evidence Anisoylated Plasminogen Streptokinase Activator Complex Anterior Infarction Intracoronary Streptokinase
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