, Volume 32, Issue 5, pp 445–457 | Cite as

Prostaglandins in Peptic Ulcer Disease

An Overview of Current Status and Future Directions
  • Stephen J. Sontag
Review Article


Naturally occurring prostaglandins almost certainly play an important role in maintaining the integrity of the gastrointestinal mucosa. Clinical evidence available to date indicates that synthetic analogues of prostaglandins heal gastroduodenal ulcer only in doses that suppress gastric acid. However, non-antisecretory doses of prostaglandins may eventually have a role in the treatment of ulcer disease by maintaining ulcer healing and preventing recurrence. This possibility along with the potential of prostaglandins to prevent gastroduodenal mucosal injury caused by NSAIDs, alcohol, aspirin and stress, if supported by the results of ongoing clinical trials, may prove to be a major therapeutic advance for the treatment of acid peptic disease.


Prostaglandin Cimetidine Duodenal Ulcer Misoprostol Peptic Ulcer Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© ADIS Press Limited 1986

Authors and Affiliations

  • Stephen J. Sontag
    • 1
    • 2
  1. 1.Departments of Ambulatory Care and MedicineEdward J. Hines Jr Veterans Administration HospitalHinesUSA
  2. 2.Department of MedicineLoyola University Medical CenterMaywoodUSA

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