, Volume 31, Supplement 2, pp 14–17 | Cite as

A Comparison of Parenteral Sulbactam/Ampicillin versus Clindamycin/Gentamicin in the Treatment of Pelvic Inflammatory Disease

  • John Gunning


60 hospitalised patients with pelvic inflammatory disease entered a randomised study to compare the therapeutic efficacy and tolerability of parenteral sulbactam/ampicillin with that of clindamycin/gentamicin. All 49 pathogens isolated at entry from 21 evaluable patients in the sulbactam/ampicillin group were eradicated. 34 out of 35 pathogens isolated from 18 evaluable patients in the clindamycin/gentamicin group were eradicated. All pathogens resistant to ampicillin in vitro were eradicated. The bacteriological, clinical and overall responses for the sulbactam/ampicillin group were 100%, 85.7% and 85.7%, respectively, compared with 97.1%, 94.4% and 94.4%, respectively, for the clindamycin/gentamicin group. The sulbactam/ampicillin combination was well tolerated.


Clindamycin Chlamydia Trachomatis Pelvic Inflammatory Disease Glycogen Storage Disease Neisseria Gonorrhoeae 
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  1. English AR, Retsema JA, Girard AE, Lynch JE, Barth WE. CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization. Antimicrobial Agents and Chemotherapy 14: 414–419, 1978PubMedCrossRefGoogle Scholar
  2. Eschenbach DA, Buchanan TM, Pollock HM, Forsyth P, Alexander ER. Polymicrobial etiology of acute pelvic inflammatory disease. New England Journal of Medicine 293: 166–171, 1975PubMedCrossRefGoogle Scholar
  3. Ledger WJ. Selection of antimicrobial agents for the treatment of infections of the female genital tract. Reviews of Infectious Diseases 5 (Suppl.): 98–104, 1983CrossRefGoogle Scholar
  4. Sweet RL. Treatment of mixed aerobic-anaerobic infections of the female genital tract. Journal of Antimicrobial Chemotherapy 8(Suppl. D): 105–114, 1981PubMedGoogle Scholar
  5. Sweet RL, Draper DL, Schachter J, James J, Hadley WK, et al.: Microbiology and pathogenesis of acute salpingitis as determined by laparoscopy: what is the appropriate site to sample? American J Obstet Gynecol 138: 985–989, 1980Google Scholar
  6. Sweet RL, Schacter J, Robbie MO. Failure of beta-lactam antibiotics to eradicate Chlamydia trachomatis in the endometrium despite apparent clinical cure of acute salpingitis. Journal of the American Medical Association 250: 2641–2645, 1983PubMedCrossRefGoogle Scholar
  7. Wise R, Andrews JM, Bedford KA. Clavulanic acid and CP-45,899: a comparison of their in vitro activity in combination with penicillins. J Antimicrob Chemother 6: 197–206, 1980PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press Limited 1986

Authors and Affiliations

  • John Gunning
    • 1
  1. 1.Harbor/UCLA Medical CenterTorranceUSA

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