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A Comparison of Parenteral Sulbactam/Ampicillin versus Clindamycin/Gentamicin in the Treatment of Pelvic Inflammatory Disease

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Summary

60 hospitalised patients with pelvic inflammatory disease entered a randomised study to compare the therapeutic efficacy and tolerability of parenteral sulbactam/ampicillin with that of clindamycin/gentamicin. All 49 pathogens isolated at entry from 21 evaluable patients in the sulbactam/ampicillin group were eradicated. 34 out of 35 pathogens isolated from 18 evaluable patients in the clindamycin/gentamicin group were eradicated. All pathogens resistant to ampicillin in vitro were eradicated. The bacteriological, clinical and overall responses for the sulbactam/ampicillin group were 100%, 85.7% and 85.7%, respectively, compared with 97.1%, 94.4% and 94.4%, respectively, for the clindamycin/gentamicin group. The sulbactam/ampicillin combination was well tolerated.

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  1. Harbor/UCLA Medical Center, 1000 West Carson Street, Box 3, Torrance, CA, 90509, USA

    John Gunning

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  1. John Gunning
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Gunning, J. A Comparison of Parenteral Sulbactam/Ampicillin versus Clindamycin/Gentamicin in the Treatment of Pelvic Inflammatory Disease. Drugs 31 (Suppl 2), 14–17 (1986). https://doi.org/10.2165/00003495-198600312-00004

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  • DOI: https://doi.org/10.2165/00003495-198600312-00004

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