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Drugs

, Volume 31, Supplement 2, pp 14–17 | Cite as

A Comparison of Parenteral Sulbactam/Ampicillin versus Clindamycin/Gentamicin in the Treatment of Pelvic Inflammatory Disease

  • John Gunning
Article

Summary

60 hospitalised patients with pelvic inflammatory disease entered a randomised study to compare the therapeutic efficacy and tolerability of parenteral sulbactam/ampicillin with that of clindamycin/gentamicin. All 49 pathogens isolated at entry from 21 evaluable patients in the sulbactam/ampicillin group were eradicated. 34 out of 35 pathogens isolated from 18 evaluable patients in the clindamycin/gentamicin group were eradicated. All pathogens resistant to ampicillin in vitro were eradicated. The bacteriological, clinical and overall responses for the sulbactam/ampicillin group were 100%, 85.7% and 85.7%, respectively, compared with 97.1%, 94.4% and 94.4%, respectively, for the clindamycin/gentamicin group. The sulbactam/ampicillin combination was well tolerated.

Keywords

Clindamycin Chlamydia Trachomatis Pelvic Inflammatory Disease Glycogen Storage Disease Neisseria Gonorrhoeae 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. English AR, Retsema JA, Girard AE, Lynch JE, Barth WE. CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization. Antimicrobial Agents and Chemotherapy 14: 414–419, 1978PubMedCrossRefGoogle Scholar
  2. Eschenbach DA, Buchanan TM, Pollock HM, Forsyth P, Alexander ER. Polymicrobial etiology of acute pelvic inflammatory disease. New England Journal of Medicine 293: 166–171, 1975PubMedCrossRefGoogle Scholar
  3. Ledger WJ. Selection of antimicrobial agents for the treatment of infections of the female genital tract. Reviews of Infectious Diseases 5 (Suppl.): 98–104, 1983CrossRefGoogle Scholar
  4. Sweet RL. Treatment of mixed aerobic-anaerobic infections of the female genital tract. Journal of Antimicrobial Chemotherapy 8(Suppl. D): 105–114, 1981PubMedGoogle Scholar
  5. Sweet RL, Draper DL, Schachter J, James J, Hadley WK, et al.: Microbiology and pathogenesis of acute salpingitis as determined by laparoscopy: what is the appropriate site to sample? American J Obstet Gynecol 138: 985–989, 1980Google Scholar
  6. Sweet RL, Schacter J, Robbie MO. Failure of beta-lactam antibiotics to eradicate Chlamydia trachomatis in the endometrium despite apparent clinical cure of acute salpingitis. Journal of the American Medical Association 250: 2641–2645, 1983PubMedCrossRefGoogle Scholar
  7. Wise R, Andrews JM, Bedford KA. Clavulanic acid and CP-45,899: a comparison of their in vitro activity in combination with penicillins. J Antimicrob Chemother 6: 197–206, 1980PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press Limited 1986

Authors and Affiliations

  • John Gunning
    • 1
  1. 1.Harbor/UCLA Medical CenterTorranceUSA

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