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The Place of Temocillin in the Treatment of Hospital Infections

  • Section 6: The Place of Temocillin in Clinical Practice
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Summary

Infection due to Gram-negative bacteria continues to be a common problem in the hospital environment, for which a wide variety of antibiotics is available. Among Enterobacteria, resistance is expressed most commonly via β-lactamases. Temocillin is the first penicillin to show stability to β-lactamases of Gram-negative bacteria, therefore it is in this type of infection that the initial assessments of temocillin should be made.

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References

  • Breuer, H.; Cimarusti, CM.; Denszel, T.; Koster, W.H.; Slusarchyk, W.A. and Treuner, U.D.: Monobactams — structure-activity relationships leading to SQ 26,776. Journal of Antimicrobial Chemotherapy 8(Suppl. E): 21–28 (1981).

    PubMed  CAS  Google Scholar 

  • Chen, H.Y. and Williams, J.D.: Temocillin compared to ampicillin against Haemophilus influenzae and with other penicillins against intestinal aerobic Gram-negative rods. Journal of Antimicrobial Chemotherapy 10: 279–287 (1982).

    Article  PubMed  Google Scholar 

  • Duckworth, G.J. and Williams, J.D.: Frequency of appearance of resistant variants to norfloxacin and nalidixic acid. Journal of Antimicrobial Chemotherapy 13(Suppl. 13): 33–38 (1984).

    PubMed  CAS  Google Scholar 

  • Ito, A.; Hirai, K.; Inoue, M.; Koga, H.; Suzue, S.; Irikura, T. and Mitsuhashi, S.: In vitro activity of AM-715, a new nalidixic acid analog. Antimicrobial Agents and Chemotherapy 17: 103–108 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Jules, K. and Neu, H.C.: Antibacterial activity and beta-lactamase stability of temocillin. Antimicrobial Agents and Chemotherapy 22: 453–460 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Kropp, K.; Sundelof, J.G.; Kahan, J.B.; Kahan, F.M. and Birnbaum, J.: MK0787 (N-formimidoyl thienamycin): Evaluation of in vitro and in vivo activities. Antimicrobial Agents and Chemotherapy 17: 993–1000 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Slocombe, B.; Basker, M.J.; Bentley, P.H.; Clayton, J.P.; Cole, M.; Comber, K.R.; Dixon, R.A.; Edmondson, R.A.; Jackson, D.; Mierrikin, D.J. and Sutherland, R.: BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans. Antimicrobial Agents and Chemotherapy 20: 38–46 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Sykes, R.B.; Cimarusti, CM.; Bonner, D.P.; Bush, K.; Floyd, D.M.; Georgopapadakou, N.H.; Koster, W.H.; Liu, W.C.; Parker, W.L.; Principe, P.A. and Rathnum, M.L.: Monocyclic beta-lactam antibiotics produced by bacteria. Nature 291: 489–491 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Whitaker, S.; Hajipieris, P. and Williams, J.D.: Distribution and type of beta-lactamase amongst 1,000 Gram-negative rod bacteria; in Spitzy et al. (Eds) Proceedings of the 13th International Congress of Chemotherapy, Vienna, Austria, 1983.

  • Williams, R.J.; Lindridge, M.A.; Said, A.A.; Livermore, D.M. and Williams, J.D.: National survey of antibiotic resistance in Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 14: 9–16 (1984b).

    Article  PubMed  CAS  Google Scholar 

  • Williams, R.J.; Livermore, D.M.; Lindridge, M.A.; Said, A.A. and Williams, J.D.: Mechanism of beta-lactam resistance in British isolates of Pseudomonas aeruginosa. Journal of Medical Microbiology 17: 283–293 (1984a).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Microbiology, The London Hospital Medical College, Turner Street, London, E1 2AD, England

    J. D. Williams & H. Y. Chen

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  1. J. D. Williams
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  2. H. Y. Chen
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Williams, J.D., Chen, H.Y. The Place of Temocillin in the Treatment of Hospital Infections. Drugs 29 (Suppl 5), 234–239 (1985). https://doi.org/10.2165/00003495-198500295-00051

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  • DOI: https://doi.org/10.2165/00003495-198500295-00051

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