Summary
Eight patients about to have the whole or part of a lung resected were given a 2g bolus dose of temocillin. A series of serum samples and a piece of peripheral lung tissue were collected and assayed for temocillin concentration. 30 minutes after drug administration, the mean serum and tissue concentrations were 172 mg/L and 45 mg/kg respectively.
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References
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Cowan, W., Baird, A., Sleigh, J.D. et al. Lung Tissue Penetration of Temocillin. Drugs 29 (Suppl 5), 151–153 (1985). https://doi.org/10.2165/00003495-198500295-00031
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DOI: https://doi.org/10.2165/00003495-198500295-00031