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Drugs

, Volume 29, Supplement 5, pp 103–105 | Cite as

Temocillin

Summary of Safety Studies
  • A. Cockburn
  • G. Mellows
  • D. Jackson
  • D. J. White
Section 2: The Clinical Pharmacology of Temocillin

Summary

Temocillin is a novel injectable β-lactam antibiotic designed for parenteral use. It is active against the majority of Gram-negative bacteria and is stable to a wide range of β-lactamases.

Disposition and metabolic studies on temocillin in animals and man demonstrate that the drug is well distributed throughout the body tissues and will cross the placenta. The major route of elimination is via the kidney (89%) where the drug is excreted unchanged as parent compound, mainly by the glomerular filtration of unbound temocillin. A full toxicological safety evaluation programme has been completed and includes acute, subacute and chronic toxicology in rat and dog, and reproductive and mutagenicity studies.

Temocillin was well tolerated in animals at dosages of up to 1000 mg/kg and appears to be without any potential hazard for man in dosages which are well in excess of the proposed therapeutic dose.

Keywords

Renal Clearance Lactam Probenecid Major Route Temocillin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Greenhill, R.W. and White, D.J.: The tissue localisation of penicillin using an immunoperoxidase technique. Human Toxicology (in press, 1985).Google Scholar
  2. Slocombe, B.; Basker, M.J.; Bentley, P.H.: Clayton, J.P. et al.: BRL 17421, a novel β-lactam antibiotic, highly resistant to β-lactamases, giving high and prolonged serum levels in humans. Antimicrobial Agents and Chemotherapy 20: 38–46 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press Limited 1985

Authors and Affiliations

  • A. Cockburn
    • 1
  • G. Mellows
    • 1
  • D. Jackson
    • 1
  • D. J. White
    • 1
  1. 1.Beecham Pharmaceuticals Research DivisonStock and HarlowEssex and BetchworthEngland

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