Drugs

, Volume 25, Supplement 2, pp 100–102 | Cite as

Haemodynamic Effects of β-Blockers

  • Jay N. Cohn
Section 2A: Pharmacodynamics, Pharmacokinetics and Drug Interactions

Summary

The pharmacological effects of β- blockers have been well documented but there is still no clear picture of the integrated systemic haemodynamic response to adrenoceptor blockade. This response is reviewed and the changes in systemic vascular resistance in hypertensive patients and during exercise are analysed.

Keywords

Cardiac Output Systemic Vascular Resistance Haemodynamic Effect Negative Inotropic Effect Haemodynamic Response 

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References

  1. Guyton, A.C.; Coleman, T.G.; Cowley, A.W.; Manning, R.O.; Norman, R.A. and Ferguson, J.D.: A systems analysis approach to understanding long-range arterial blood pressure control. Circulation Research 35: 159–176 (1974).CrossRefGoogle Scholar
  2. Simon, G.; Kiowski, W. and Julian, S.: Effect of systemic autonomic inhibition on the haemodynamic response to anti-hypertensive therapy with timolol. International Journal of Clinical Pharmacology and Biopharmacy 12: 507–510 (1979).Google Scholar
  3. Simon, G.; Franciosa, J.A.; Gimenez, H.J. and Cohn, J.N.: Short-term systemic hemodynamic adaptation to beta-adrenergic inhibition with atenolol in hypertensive patients. Hypertension 3: 262–268 (1981).PubMedCrossRefGoogle Scholar
  4. Swedberg, K.; Hjalmarson, A.; Waagstein, F. and Wallentin, I.: Beneficial effects of long-term beta-blockade in congestive cardiomyopathy. British Heart Journal 44: 117–133 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© ADIS Press Australasia Pty Ltd (Inc. NSW) 1983

Authors and Affiliations

  • Jay N. Cohn
    • 1
  1. 1.Cardiovascular Division, Department of MedicineUniversity of Minnesota Medical SchoolMinneapolisUSA

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