, Volume 25, Supplement 2, pp 64–68 | Cite as

Activation of Prejunctional β-Adrenoceptors by Adrenaline Acting as a Co-transmitter

A Possible Cause of Hypertension
  • M. J. Rand
  • H. Majewski
  • L.-H. Tung
Section 1B: Hypertension


Adrenaline released into the circulation can be accumulated in sympathetic nerve endings. Release of adrenaline from the nerves enhances noradrenaline release, as adrenaline activates a local modulatory system mediated by presynaptic β-adrenoceptors. It is postulated that stress-induced adrenaline release from the adrenal gland could, through this mechanism, lead to hypertension.


Adrenaline Sympathetic Nerve Plasma Adrenaline Sential Hypertension Human Essential Hypertension 
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Copyright information

© ADIS Press Australasia Pty Ltd (Inc. NSW) 1983

Authors and Affiliations

  • M. J. Rand
    • 1
    • 2
  • H. Majewski
    • 1
    • 2
  • L.-H. Tung
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of MelbourneMelbourneAustralia
  2. 2.Pharmakologisches Institut der UniversitätFreiburgAustralia

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