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Atenolol Dose-Finding Studies

  • Section 1B: Hypertension
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Summary

The relationship between oral dose and plasma concentration of the long acting cardioselective β-blocker, atenolol, and the antihypertensive response to the degree of β-blockade and change in plasma renin activity was evaluated in 20 patients with mild-to-moderate hypertension in a double-blind, randomised, between-patient, dose-ranging (25, 50 or 100mg once daily for 4 weeks) study. It is concluded that being unmetabolised and renally excreted, atenolol has a long biological action with a mean elimination half-life of approximately 10 hours. This enables a low dose to be given on a once daily basis, resulting in 24-hour cover for mild-to-moderate essential hypertension.

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Authors and Affiliations

  1. Division of Clinical Pharmacology, National Medical Centre, Tokyo, Japan

    T. Ishizaki

  2. Division of Cardiology, Tonan Hospital, Sapporo, Japan

    Y. Oyama

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  1. T. Ishizaki
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  2. Y. Oyama
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Ishizaki, T., Oyama, Y. Atenolol Dose-Finding Studies. Drugs 25 (Suppl 2), 42–49 (1983). https://doi.org/10.2165/00003495-198300252-00009

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  • DOI: https://doi.org/10.2165/00003495-198300252-00009

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