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Antineoplastic Drugs: Clinical Pharmacology and Therapeutic Use

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References

  • Adamson, I.Y. and Bowden, D.H.: The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. American Journal of Pathology 77: 185–197 (1974).

    PubMed  CAS  Google Scholar 

  • Adamson, R.H.: Daunomycin and adriamycin: A hypothesis concerning antitumor activity and cardiotoxicity. Cancer Chemotherapy Reports 58(1): 293–294 (1974).

    CAS  Google Scholar 

  • Alberts, D.S. and van Daalen Wetters, T.: The effect of phenobarbital on cyclophosphamide antitumor activity. Cancer Research 36: 2785–2789 (1976a).

    PubMed  CAS  Google Scholar 

  • Alberts, D.S. and van Daalen Wetters, T.: The effect of allopurinol on cyclophosphamide antitumor activity. Cancer Research 36: 2790–2794 (1976b).

    PubMed  CAS  Google Scholar 

  • Allen, L.M. and Creaven, P.J.: Comparison of the human pharmacokinetics of VM-26 and VP-16, two antineoplastic epipodophyllotoxin glucopyranoside derivatives. European Journal of Cancer 11: 697–707 (1975).

    PubMed  CAS  Google Scholar 

  • Ambre, J.J. and Fischer, L.J.: The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats. Journal of Laboratory and Clinical Medicine 78: 343–353 (1971).

    PubMed  CAS  Google Scholar 

  • Ansfield, F.; Klotz, J.; Nealon, T. et al.: A phase III study comparing the clinical utility of four regimens of 5-fluorouracil. A preliminary report. Cancer 39: 34–40 (1977).

    PubMed  CAS  Google Scholar 

  • Arcamone, F.; Bernardi, L.; Gardino, P. et al.: Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7-9-diepidaunorubicin, and their β anomers. Cancer Treatment Reports 60: 829–834 (1976).

    PubMed  CAS  Google Scholar 

  • Arena, B.; D’Alessandro, N.; Dusonchet, L. et al.: Influence of pharmacokinetic variations on the pharmacologic properties of adriamycin; in Carter, DiMarco, Ghione et al. (Eds) International Symposium on Adriamycin, p.96–116 (Springer-Verlag, New York 1972).

    Google Scholar 

  • Arnold, H. and Bourseaux, F.: Synthese und Abbau cytostatisch wirksamer cyclischer N-phosphamidester des bis-(β-chlorathyl)-amins. Angew Chem (Engl) 70: 539–544 (1958).

    CAS  Google Scholar 

  • Bachur, N.R.; Reiter, W. and Arena, E.: Cardiac uptake of adriamycin (NSC-123127) not affected by stropanthin G (NSC-25485). Cancer Chemotherapy Reports 59: 765–766 (1975).

    CAS  Google Scholar 

  • Bachur, N.R.; Riggs, C.E.; Green, M.R. et al.: Plasma adriamycin and daunorubicin levels by fluorescence and radioimmunoassay. Clinical Pharmacology and Therapeutics 21: 70–77 (1977).

    PubMed  CAS  Google Scholar 

  • Bacigalupo, G.: Uncoupling the oxidative phosphorylation in the combined chemotherapy of cancer. Acta Unio International Journal of Cancer 20: 52–53 (1964).

    CAS  Google Scholar 

  • Bagley, C.M.; Bostick, F.W. and DeVita, V.T.: Clinical pharmacology of cyclophosphamide. Cancer Research 33: 226–233 (1973).

    PubMed  Google Scholar 

  • Band, P.R.; Holland, J.F.; Bernard, J. et al.: Treatment of central nervous system leukemia with intrathecal cytosine arabinoside. Cancer 32: 744–748 (1973).

    PubMed  CAS  Google Scholar 

  • Barlogie, B.; Drewinko, B.; Johnston, D.A. et al.: The effect of adriamycin on the cell cycle traverse of a human lymphoid cell line. Cancer Research 36: 1975–1979 (1976).

    PubMed  CAS  Google Scholar 

  • Bearden, J. Jr and Haidle, C.W.: Stimulation of bleomycin-induced fragmentation of DNA by intercalating agents. Biochemical and Biophysical Research Communications 65: 371–377 (1975).

    PubMed  CAS  Google Scholar 

  • Beck, D.J. and Brubaker, R.R.: Effect of cis-platinum (II) diamminodichloride on wild type and deoxyribonucleic acid repair-deficient mutants of Escherichia coli. Journal of Bacteriology 116: 1247–1252 (1973).

    PubMed  CAS  Google Scholar 

  • Beck, D.J. and Brubaker, R.R.: Mutagenic properties of cis-platinum (II) diamminodichloride in Escherichia coli. Mutation Research 27: 181–189 (1975).

    PubMed  CAS  Google Scholar 

  • Bellet, R.E.; Mastrangelo, M.J.; Engstrom, P.F. et al.: Hepatotoxicity of 5-azacytidine (NSC-102816) (a clinical and pathologic study). Neoplasma 20: 303–309 (1973).

    PubMed  CAS  Google Scholar 

  • Bender, R.A.; Bleyer, W.A.; Frisby, S.A. et al.: Alteration of methotrexate uptake in human leukemia cells by other agents. Cancer Research 35: 1305–1308 (1975).

    PubMed  CAS  Google Scholar 

  • Bender, R.A.; Castle, M.C.; Margileth, D.A. et al.: The pharmacokinetics of [3H]-vincristine in man. Clinical Pharmacology and Therapeutics. 22: 430–438 (1977).

    PubMed  CAS  Google Scholar 

  • Benjamin, R.S.: Clinical pharmacology of adriamycin (NSC-123127). Cancer Chemother. Rep. 6(3): 183–185 (1975a).

    Google Scholar 

  • Benjamin, R.S.: A practical approach to adriamycin (NSC-123127) toxicology. Cancer Chemotherapy Reports 6(3): 191–194 (1975b).

    Google Scholar 

  • Benjamin, R.S.; Riggs, C.E. and Bachur, N.R.: Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function. Cancer Research 37: 1416–1420 (1977).

    PubMed  CAS  Google Scholar 

  • Benjamin, R.S.; Wiernik, P.H. and Bachur, N.R.: Adriamycin chemotherapy — efficacy, safety, and pharmacologic basis of an intermittent single high-dosage schedule. Cancer 33: 19–27 (1974).

    PubMed  CAS  Google Scholar 

  • Bhattacharyya, B. and Wolff, J.: Maytansine binding to the vinblastine sites of tubulin. Federation of European Biochemical Societies Letters 75: 159–162 (1977).

    PubMed  CAS  Google Scholar 

  • Bick, R.L.; Fekete, L.F. and Wilson, W.L.: Adriamycin and fibrinolysis. Thrombosis Research 8: 467–475 (1976).

    PubMed  CAS  Google Scholar 

  • Birnie, G.D.; Kroeger, H. and Heidelberger, C.: Studies of fluorinated pyrimidines. XVIII. The degradation of 5-fluoro-2*-deoxyuridine and related compounds by nucleoside Phosphorylase. Biochemistry 2: 566–572 (1963).

    PubMed  CAS  Google Scholar 

  • Bleyer, W.A.: Clinical pharmacology of intrathecal methotrexate. II. An improved dosage regimen derived from age-related pharmacokinetics. Cancer Treatment Reports. 61: 1419–1425 (1977).

    PubMed  CAS  Google Scholar 

  • Bleyer, W.A. and Dedrick, R.L.: Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection. Cancer Treatment Reports 61: 703–708 (1977).

    PubMed  CAS  Google Scholar 

  • Bleyer, W.A.; Drake, J.C and Chabner, B.A.: Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia. New England Journal of Medicine 289: 770–773 (1973).

    PubMed  CAS  Google Scholar 

  • Bleyer, W.A.; Frisby, S.A. and Oliverio, V.T.: Uptake and binding of vincristine by murine leukemia cells. Biochemical Pharmacology 24: 633–639 (1975).

    PubMed  CAS  Google Scholar 

  • Blum, R.H.; Carter, S.K. and Agre, K.: A clinical review of bleomycin: A new antineoplastic agent. Cancer 31: 903–913 (1973).

    PubMed  CAS  Google Scholar 

  • Blum, R.H. and Dawson, D.M.: Vindesine (V)-Phase I study of a Vinca alkaloid. Proceedings of the American Association for Cancer Research 17: 108 (1976).

    Google Scholar 

  • Bodey, G.P.; Freireich, E.J.; Monto, R.W. et al.: Cytosine arabinoside (NSC 63878) therapy for acute leukemia in adults. Cancer Chemotherapy Reports 53: 59–66 (1969).

    CAS  Google Scholar 

  • Bonadonna, G.; Monfardini, S.; DeLena, M. et al.: Clinical trials with adriamycin. Results of three years study; in Carter; DiMarco; Ghione et al. (Eds) International Symposium on Adriamycin, p. 139–152 (Springer Verlag, New York 1972).

    Google Scholar 

  • Bourke, R.S.; West, C.R.; Chheda, G. et al.: Kinetics of entry and distribution of 5-fluorouracil in cerebrospinal fluid and brain following intravenous injection in a primate. Cancer Research 33: 1735–1746 (1973).

    PubMed  CAS  Google Scholar 

  • Bristow, M.; Mason, J.; Billingham, M. et al.: Clinical evaluation of adriamycin cardiomyopathy. Proceedings of the American Society of Clinical Oncology 18: 334 (1977).

    Google Scholar 

  • Broughton, A. and Strong, J.E.: Radioimmunoassay of bleomycin. Cancer Research 36: 1418–1421 (1976).

    PubMed  CAS  Google Scholar 

  • Bruckner, H.W. and Creasey, W.A.: The administration of 5-fluorouracil by mouth. Cancer 33: 14–18 (1974).

    PubMed  CAS  Google Scholar 

  • Bruckner, H.W.; Schreiber, C. and Waxman, S.: Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis. Cancer Research 35: 801–806 (1975).

    PubMed  CAS  Google Scholar 

  • Buckner, C.D.; Rudolph, R.H.; Fefer, A. et al.: High-dose cyclophosphamide therapy for malignant disease. Toxicity, tumor response, and the effects of stored autologous marrow. Cancer 29: 357–365 (1972).

    Google Scholar 

  • Burgess, M.A.; Bodey, G.P.; Minow, R.A. et al.: Phase I-II evaluation of cyclocytidine. Cancer Treatment Reports 61: 437–443 (1977).

    PubMed  CAS  Google Scholar 

  • Buroker, T.; Samson, M.; Correa, J. et al.: Hepatic artery infusion of 5-FUdR after prior systemic 5-fluorouracil. Cancer Treatment Reports 60: 1277–1279 (1976).

    PubMed  CAS  Google Scholar 

  • Byfield, J.B.; Lee, Y.C. and Tu, L.: Molecular interactions between adriamycin and x-ray damage in mammalian tumor cells. International Journal of Cancer 19: 186–193 (1977).

    CAS  Google Scholar 

  • Capizzi, R.L.; Keiser, L.W. and Sartorelli, A.C.: Combination chemotherapy — theory and practice. Seminars in Oncology 4: 227–253 (1977).

    PubMed  CAS  Google Scholar 

  • Carter, S.K.: Single and combination nonhormonal chemotherapy in breast cancer. Cancer 30: 1543–1555 (1972).

    PubMed  CAS  Google Scholar 

  • Carter, S.K.: Adriamycin — A Review. Journal of the National Cancer Institute 55: 1265–1274 (1975).

    PubMed  CAS  Google Scholar 

  • Carter, S.K. and Livingston, R.B.: Plant products in cancer chemotherapy. Cancer Treatment Reports 60: 1141–1156 (1976).

    PubMed  CAS  Google Scholar 

  • Cassady, J.R.; Richter, M.P.; Piro, A.J. et al.: Radiation-adriamycin interactions: Preliminary clinical observations. Cancer 36: 946–949 (1975).

    PubMed  CAS  Google Scholar 

  • Castle, M.C.; Margileth, D.A. and Oliverio, V.T.: Distribution and excretion of [3H]vincristine in the rat and the dog. Cancer Research 36: 3684–3689 (1976).

    PubMed  CAS  Google Scholar 

  • Chabner, B.A.; Johns, D.G.; Coleman, C.N. et al.: Purification and properties of cytidine deaminase from normal and leukemic granulocytes. Journal of Clinical Investigation 53: 922–931 (1974).

    PubMed  CAS  Google Scholar 

  • Chabner, B.A.; Levine, A.; Adamson, R. et al.: Initial clinical and pharmacological studies of Maytansine. Proceedings of the American Association for Cancer Research 18: 129 (1977).

    Google Scholar 

  • Chabner, B.A. and Young, R.C.: Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues. Journal of Clinical Investigation 52: 1804–1811 (1973).

    PubMed  CAS  Google Scholar 

  • Chang, P.; Wiernik, P.; Bachur, N. et al.: Failure to predict response of acute non-lymphocytic leukemia using assays for deoxycytidine kinase, cytidine deaminase, and daunomycin reductase. Proceedings of the American Society of Clinical Oncology 18: 352 (1977).

    Google Scholar 

  • Chary, K.K.; Higby, D.J.; Henderson, E.S. et al.: Phase I study of high-dose cis-dichlorodiammine platinum (II) with forced diuresis. Cancer Treatment Reports 61: 367–370 (1977).

    PubMed  CAS  Google Scholar 

  • Chaudhuri, N.K.; Montag, B.J. and Heidelberger, C.: Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-14C and 5-fluorourotic acid-2-l4C in vivo. Cancer Research 18: 318–328 (1958).

    PubMed  CAS  Google Scholar 

  • Chou, T.G; Hutchinson, D.J.; Schmid, F.A. et al.: Metabolism and selective effects of 1-β-D arabinofuranosylcytosine in L1210 and host tissue in vivo. Cancer Research 35: 225–236 (1975).

    PubMed  CAS  Google Scholar 

  • Chu, M.Y.: Incorporation of arabinosyl cytosine into 27S ribonucleic acid and cell death. Biochemical Pharmacology 20: 2057–2064 (1971).

    PubMed  CAS  Google Scholar 

  • Cihak, A.; Vesely, J. and Sorm, F.: Complete inhibition by 5-azacytidine of hormonal induction of tryptophan pyrrolase. Biochimica et Biophysica Acta 134: 486–489 (1967).

    CAS  Google Scholar 

  • Clarkson, B.; O’Connor, A.; Winston, L. et al.: The physiologic disposition of 5-fluorouracil and 5-fluoro-2’-deoxyuridine in man. Clin. Pharmacol. Thera. 5: 581–610 (1965).

    Google Scholar 

  • Clarkson, J.M. and Humphrey, R.M.: The effect of adriamycin on cell cycle progression and DNA replication in Chinese hamster ovary cells. Cancer Research 37: 200–205 (1977).

    PubMed  CAS  Google Scholar 

  • Cohen, A.M.: The disposition of ftorafur in rats after intravenous administration. Drug Metabolism and Disposition 3: 303–308 (1975).

    PubMed  CAS  Google Scholar 

  • Cohen, J.L.; Irwin, L.E.; Marshall, G.J. et al.: Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893). Cancer Chemotherapy Reports 58: 723–731 (1974).

    CAS  Google Scholar 

  • Cohen, S.S.; Flaks, J.G.; Barner, H.D. et al.: The mode of action of 5-fluorouracil and its derivatives. Proceedings of the National Academy of Science U.S.A. 44: 1004–1012 (1958).

    CAS  Google Scholar 

  • Cooper, G.M.; Dunning, W.F. et al.: Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo. Cancer Research 32: 390–397 (1972).

    PubMed  CAS  Google Scholar 

  • Creasey, W.A.: Modifications in biochemical pathways produced by the Vinca alkaloids. Cancer Chemotherapy Reports 52: 501–507 (1968).

    CAS  Google Scholar 

  • Creasey, W.A. and Markiw, M.E.: Biochemical effects of the Vinca alkaloids. III. The synthesis of ribonucleic acid and the incorporation of amino acids in Ehrlich ascites cells in vitro. Biochimica et Biophysica Acta 103: 635–645 (1965).

    PubMed  CAS  Google Scholar 

  • Creasey, W.A.; Mcintosh, L.S.; Brescia, T. et al.: Clinical effects and pharmacokinetics of different dosage schedules of adriamycin. Cancer Research 36: 216–221 (1976).

    PubMed  CAS  Google Scholar 

  • Creasey, W.A.; Scott, A.I.; Wei, C.G. et al.: Pharmacologic studies with vinblastine in the dog. Cancer Research 35: 1116–1120 (1975).

    PubMed  CAS  Google Scholar 

  • Creaven, P.J. and Allen, L.M.: EPEG, a new antineoplastic epipodophyllotoxin. Clinical Pharmacology and Therapeutics 18: 221–226 (1975a).

    PubMed  CAS  Google Scholar 

  • Creaven, P.J. and Allen, L.M.: PTG, a new antineoplastic epipodophyllotoxin. Clinical Pharmacology and Therapeutics 18: 227–232 (1975b).

    PubMed  CAS  Google Scholar 

  • Creaven, P.J.; Newman, S.J.; Selawry, O.S. et al.: Clinical trial of weekly administration of 4’-demethylepipodophyllotoxin 9-(4,6-0-ethylidene-β-D-glucopyranoside (NSC-141540; VP-16-213). Cancer Chemother. Rep. 58: 901–907 (1974).

    PubMed  CAS  Google Scholar 

  • Curreri, A.R.; Ansfield, F.J.; McIver, F.A. et al.: Clinical studies with 5-fluorouracil. Cancer Research 18: 478–484 (1958).

    PubMed  CAS  Google Scholar 

  • DeConti, R.C.; Toftness, B.R.; Lange, R.C. et al.: Clinical and pharmacological studies with cis-diamminedichloroplatinum (II). Cancer Research 33: 1310–1315 (1973).

    PubMed  CAS  Google Scholar 

  • DeFronzo, R.A.; Braine, H.; Colvin, M.O. et al.: Water intoxication in man after cyclophosphamide therapy: Time course and relation to drug activation. Annals of Internal Medicine 78: 861–869 (1973).

    PubMed  CAS  Google Scholar 

  • Dentino, M.E.; Yum, M.N.; Rohn, R.J. et al.: The long-term effect of cis-platinum diamminedichloride on renal function in man. Proceedings of the American Association for Cancer Research 18: 116 (1977).

    Google Scholar 

  • DiMarco, A.: Adriamycin (NSC-123127): Mode and mechanism of action. Cancer Chemotherapy Reports 6(3): 91–106 (1975).

    CAS  Google Scholar 

  • DiMarco, A.; Casazza, A.M.; Gambetta, R. et al.: Relationship between activity and amino sugar stereochemistry of daunorubicin and adriamycin derivatives. Cancer Research 36: 1962–1966 (1976).

    CAS  Google Scholar 

  • Dixon, R.L.: Effect of chloramphenicol on the metabolism and lethality of cyclophosphamide in rats. Proceedings of the Soc. Experi. Bio. Med. 127: 1151–1155 (1968).

    CAS  Google Scholar 

  • Dixon, R.L.; Henderson, E.S. and Rail, D.P.: Plasma protein binding of methotrexate and its displacement by various drugs. Federation Proceedings 24: 454 (1965).

    Google Scholar 

  • Drake, J.C.; Stoller, R.G. and Chabner, B.A.: Characterization of the enzyme uridine-cytidine kinase isolated from a cultured human cell line. Biochemical Pharmacology 26: 64–66 (1977).

    PubMed  CAS  Google Scholar 

  • Drewinko, B.; Brown, B.W. and Gottlieb, J.A.: The effect of cisdiamminedichloroplatinum (II) on cultured human lymphoma cells and its therapeutic implications. Cancer Research 33: 3091–3095 (1973).

    PubMed  CAS  Google Scholar 

  • Duncan, J.H.; Colvin, M.O. and Fenselau, C.: Mass spectrometric study of the distribution of cyclophosphamide in humans. Toxicology and Applied Pharmacology 24: 317–323 (1973).

    PubMed  CAS  Google Scholar 

  • Ellison, R.R.; Holland, J.F.; Weil, M. et al.: Arabinosylcytosine: a useful agent in the treatment of acute leukemia in adults. Blood 32: 507–523 (1968).

    PubMed  CAS  Google Scholar 

  • Ensminger, W.D. and Frei, E.: The prevention of methotrexate toxicity by thymidine infusion in humans. Cancer Research 37: 1857–1863 (1977).

    PubMed  CAS  Google Scholar 

  • EORTC: Clinical screening of epipodophyllotoxin VM26 in malignant lymphomas and solid tumors. British Medical Journal 2: 744–748 (1972).

    Google Scholar 

  • EORTC: Epipodophyllotoxin VP 16213 in treatment of acute leukemias, haematosarcomas, and solid tumors. British Medical Journal 3: 199–202 (1973).

    Google Scholar 

  • Etcubanas, E. and Wilbur, J.R.: Uncommon side effects of adriamycin. Cancer Chemotherapy Reports 58: 757–758 (1974).

    CAS  Google Scholar 

  • Evans, J.S.; Musser, E.A.; Mengel, C.D. et al.: Antitumor activity of 1 -β-D-arabinofuranosyl cytosine hydrochloride. Proceedings of the Society for Experimental Biology and Medicine 106: 350–353 (1961).

    PubMed  CAS  Google Scholar 

  • Fenselau, C.: Review of the metabolism and mode of action of cyclophosphamide. Journal of the Association of Official Analytical Chemists 59: 1028–1036 (1976).

    CAS  Google Scholar 

  • Field, R.B.; Gang, M.; Kline, I. et al.: The effect of phenobarbital or 2-diethylaminoethyl-2,2-diphenylvalerate on the activation of cyclophosphamide in vivo. Journal of Pharmacology and Experimental Therapeutics 180: 475–483 (1972).

    PubMed  CAS  Google Scholar 

  • Finn, C. and Sadee, W.: Determination of 5-fluorouracil (NSC-19893) plasma levels in rats and man by isotope dilution-mass fragmentography. Cancer Chemotherapy Reports 59: 279–286 (1975).

    CAS  Google Scholar 

  • Frei, E.; Bickers, J.N.; Hewlett, J.S. et al.: Dose schedule and antitumor studies of arabinosylcytosine (NSC-63878). Cancer Research 29: 1325–1332 (1969).

    PubMed  CAS  Google Scholar 

  • Gabbay, E.J.; Grier, D.; Fingerle, R.E. et al.: Interaction specificity of the anthracyclines with deoxyribonucleic acid. Biochemistry 15: 2062–2070 (1976).

    PubMed  CAS  Google Scholar 

  • Ghione, M.: Development of adriamycin (NSC-123127). Cancer Chemotherapy Reports 6(3): 83–89 (1975).

    CAS  Google Scholar 

  • Goldman, I.D.; White, J.C. and Loftfield, S.: Mechanism of activation of methotrexate. III. Free intracellular methotrexate is required for maximal suppression of 14C-formate incorporation into nucleic acids and protein. Molecular Pharmacology 11: 287–297 (1975).

    PubMed  Google Scholar 

  • Gonzalez-Vitale, J.C.; Hayes, D.M.; Cvitkovic, E. et al.: The renal pathology in clinical trials of cis-platinum (II) diamminedichloride. Cancer 39: 1362–1371 (1977).

    Google Scholar 

  • Goodman, M.F.; Lee, G.M. and Bachur, N.R.: Adriamycin interactions with T4 DNA polymerase. Journal of Biological Chemistry 252: 2670–2674 (1977).

    PubMed  CAS  Google Scholar 

  • Gray, G.D.: The immunosuppressive activity of ara-C (cytarabine) and derivatives. Transplantation Proceedings 5: 1203–1209 (1973).

    PubMed  CAS  Google Scholar 

  • Greco, F.A.; Brereton, H.D.; Kent, H. et al.: Adriamycin and enhanced radiation reaction in normal esophagus and skin. Annals of Internal Medicine 85: 294–298 (1976).

    PubMed  CAS  Google Scholar 

  • Grindey, G. and Moran, R.: Effects of allopurinol on the therapeutic efficacy of methotrexate. Cancer Research 35: 1702–1705 (1975).

    PubMed  CAS  Google Scholar 

  • Hahn, G.M. and Strande, D.P.: Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cells. Journal of the National Cancer Institute 57: 1063–1067 (1976).

    PubMed  CAS  Google Scholar 

  • Hahn, G.M.; Braun, J. and Har-Kedar, I.: Thermochemotherapy: Synergism between hyperthermia (42–43 degrees) and adriamycin (or bleomycin) in mammalian cell inactivation. Proceedings of the National Academy of Sciences U.S.A 72: 937–945 (1975).

    CAS  Google Scholar 

  • Hahn, R.G.; Moertel, C.G.; Schutt, A.J. et al.: A double-blind comparison of intensive course 5-fluorouracil by oral vs. intravenous route in the treatment of colorectal carcinoma. Cancer 35: 1031–1035 (1975).

    PubMed  CAS  Google Scholar 

  • Hanasono, G.K. and Fischer, L.J.: Plasma levels and urinary excretion of [14C] cyclophosphamide and its radioactive metabolites in rats pretreated with prednisolone. Biochemical Pharmacology 21: 272–276 (1972).

    PubMed  CAS  Google Scholar 

  • Hande, K.R. and Chabner, B.A.: Deoxycytidine monophosphate kinase from human leukemic leukocytes. Proceedings of the American Association for Cancer Research 17: 67 (1976).

    Google Scholar 

  • Harbors, E.; Chaudhuri, N.K. and Heidelberger, C.: Studies of fluorinated pyrimidines. VIII. Further biochemical and metabolic investigations. Journal of Biological Chemistry 234: 1255–1262 (1959).

    Google Scholar 

  • Hardaker, W.T.; Stone, R.A. and McCoy, R.: Platinum nephrotoxicity. Cancer 34: 1030–1032 (1974).

    PubMed  Google Scholar 

  • Harder, H.C.: Renaturation effects of cis and trans platinum II and IV compounds on calf thymus deoxyribonucleic acid. Chemical-Biological Interactions 10: 27–39 (1975).

    CAS  Google Scholar 

  • Harder, H.C. and Rosenberg, B.: Inhibitory effects of antitumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in vitro. International Journal of Cancer 6: 207–216 (1970).

    CAS  Google Scholar 

  • Harris, P.A. and Gross, J.F.: Preliminary pharmacokinetic model for adriamycin (NSC-123127). Cancer Chemotherapy Reports 59(1): 819–825 (1975).

    CAS  Google Scholar 

  • Haskell, C.M.; Eilber, F.R. and Morton, D.L.: Adriamycin (NSC-123127) by arterial infusion. Cancer Chemotherapy Reports 6(3): 187–189 (1975).

    Google Scholar 

  • Hayakawa, T.; Kanai, N.; Yamada, R. et al.: Effect of steroid hormone on activation of endoxan (cyclophosphamide). Biochemical Pharmacology 18: 129–135 (1969).

    PubMed  CAS  Google Scholar 

  • Hayes, D.M.; Cvitkovic, E.; Golbey, R.B. et al.: High dose cis-platinum diamminedichloride. Cancer 39: 1372–1381 (1977).

    PubMed  CAS  Google Scholar 

  • Heidelberger, C.: Fluorinated pyrimidines and their nucleosides; in Sartorelli and Johns (Eds) Handbook of Experimental Pharmacology, p. 193–231 (Springer-Verlag, New York 1974).

    Google Scholar 

  • Heidelberger, C.; Ghobar, A.; Baker, R.K. et al.: Studies on fluorinated pyrimidines. X. In vivo studies on tumor resistance. Cancer Research 20: 897–902 (1960).

    PubMed  CAS  Google Scholar 

  • Heidelberger, C.; Griesbach, L.; Cruz, O. et al.: Fluorinated pyrimidines. VI. Effects of 5-fluorouridine and 5-fluoro-2′-deoxyuridine on transplanted tumors. Proceedings of the Society of Experimental Biology 97: 470–475 (1958).

    CAS  Google Scholar 

  • Heinen, E. and Bassleer, R.: Mode of action of cis-dichlorodiammine platinum (II) on mouse Ehrlich ascites tumour cells. Biochemical Pharmacology 25: 1871–1875 (1976).

    PubMed  CAS  Google Scholar 

  • Higby, D.J.; Buchholtz, L.; Chary, K. et al.: Kinetics of cis-platinum with intensive diuresis. Proceedings of the American Association for Cancer Research 18: 110 (1977).

    Google Scholar 

  • Higby, D.J.; Wallace, H.J., Jr and Holland, J.F.: Cis-diamminedichloroplatinum (NSC-119875): A phase I study. Cancer Chemotherapy Reports 57: 459–463 (1973).

    CAS  Google Scholar 

  • Hill, D.L.; Laster, W.R. and Struck, R.F.: Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite. Cancer Research 32: 658–665 (1972).

    PubMed  CAS  Google Scholar 

  • Ho, D.H.W. and Frei, E.: Clinical pharmacology of 1-β-D-arabinofuranosylcytosine. Clinical Pharmacology and Therapeutics 12: 944–954 (1971).

    PubMed  CAS  Google Scholar 

  • Hodes, M.E.; Rohn, R.J. and Bond, W.E.: Vincaleukoblastine. I. Preliminary Clinical Studies. Cancer Research 20: 1041–1049 (1960).

    PubMed  CAS  Google Scholar 

  • Holoye, P.Y.; Broughton, A.; Strong, J.E. et al.: Bleomycin pharmacokinetics of continuous intravenous infusion. Proceedings of the American Association for Cancer Research 17: 70 (1977).

    Google Scholar 

  • Horacek, P. and Drobnik, J.: Interaction of cis-dichlorodiam-mineplatinum (II) with DNA. Biochima et Biophysica Acta 254: 341–347 (1971).

    CAS  Google Scholar 

  • Horton, J.; Olson, K.B.; Sullivan, J. et al.: 5-Fluorouracil in cancer: An improved regimen. Annals of Internal Medicine 73: 897–900 (1970).

    Google Scholar 

  • Howie, J.A. and Gale, G.R.: Cis-dichlorodiammineplatinum (II). Persistent and selective inhibition of deoxyribonucleic acid synthesis in vivo. Bio. Pharmacol. 19: 2757–2762 (1970).

    Google Scholar 

  • Howie, J.A.; Thompson, H.S.; Stone, A.E. et al.: Cisdichlorodiammineplatinum [II]: Inhibition of nucleic acid synthesis in lymphocytes stimulated with phytohemagglutinin. Proceedings of the Society for Experimental Biology and Medicine 137: 820–826 (1971).

    Google Scholar 

  • Huffman, D.H.; Wan, S.H.; Azarnoff, D.L. and Hoogstraten, B.: Pharmacokinetics of methotrexate. Clinical Pharmacology and Therapeutics 14: 572–579 (1973).

    PubMed  CAS  Google Scholar 

  • Hum, G.J. and Bateman, J.R.: 5-Day IV infusion with 5-fluorouracil (5-FU; NSC-19893) for gastroenteric carcinoma after failure on weekly 5-FU therapy. Cancer Chemotherapy Reports 59: 1177–1179 (1975).

    Google Scholar 

  • Ishida, R. and Takahashi, T.: Increased DNA chain breakage by combined action of bleomycin and superoxide radical. Biochemical and Biophysical Research Communications 66: 1432–1438 (1975).

    PubMed  CAS  Google Scholar 

  • Israel, M.; Modest, B.J. and Frei, E.: N-trifluoroacetyl adriamycin-14-valerate, an analog with greater experimental antitumor activity and less toxicity than adriamycin. Cancer Research 35: 1365–1368 (1975).

    PubMed  CAS  Google Scholar 

  • Isralli, Z.H.; Vogler, W.; Mingioli, E. et al.: The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by constant infusion. Cancer Research 36: 1453–1461 (1976).

    Google Scholar 

  • Jacobs, E.M.; Reeves, W.J.; Wood, D.A. et al.: Treatment of cancer with weekly intravenous 5-fluorouracil. Cancer 27: 1302–1305 (1971).

    PubMed  CAS  Google Scholar 

  • Jacobs, S.A.; Bleyer, W.A.; Chabner, B.A. et al.: Altered plasma pharmacokinetics of methotrexate administered intrathecally. Lancet 1: 465–466 (1975). Letter.

    PubMed  CAS  Google Scholar 

  • Jacobs, S.A.; Stoller, R.G.; Chabner, B.A. et al.: 7-Hydroxy-methotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high-dose methotrexate. Journal of Clinical Investigation 57: 534–538 (1976).

    PubMed  CAS  Google Scholar 

  • Jacquez, J.A.: Permeability of Ehrlich cells to uracil, thymine and fluorouracil. Proceedings of the Society of Experimental Biology and Medicine 109: 132–135 (1962).

    CAS  Google Scholar 

  • Jaffe, N.; Frei, E.; Traggis, D. et al.: Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. New England Journal of Medicine 291: 994–997 (1974).

    PubMed  CAS  Google Scholar 

  • Jao, J.Y.; Jusko, W.J. and Cohen, J.L.: Phenobarbitol effects on cyclophosphamide pharmacokinetics in man. Cancer Research 32: 2761–2764 (1972).

    PubMed  CAS  Google Scholar 

  • Johnson, I.S.; Armstrong, J.C.; Gorman, M. et al.: The Vinca alkaloids: A new class of oncolytic agents. Cancer Research 23: 1390–1427 (1963).

    PubMed  CAS  Google Scholar 

  • Johnson, I.S.; Wright, H.F.; Svoboda, G.H. et al.: Antitumor principles derived from Vinca rosea linn. I. Vincaleukoblastine and leurosine. Cancer Research 20: 1016–1022 (1960).

    PubMed  CAS  Google Scholar 

  • Karon, M.; Freireich, E.J. and Frei, E.: A preliminary report on vincristine sulfate — A new active agent for the treatment of acute leukemia. Pediatrics 30: 791–796 (1962).

    Google Scholar 

  • Keller-Juslen, G.; Kuhn, M.; Von Wartburg, A. et al.: Synthesis and antimitotic activity of glycosidic lignan derivatives related to podophyllotoxin. Journal of Medicinal Chemistry 14: 936–940 (1971).

    PubMed  CAS  Google Scholar 

  • Kent, R.J. and Heidelberger, C.: Fluorinated pyrimidines. XL. The reduction of 5-fluorouridine-5′-diphosphate by ribonucleotide reductase. Molecular Pharmacology 8: 465–475 (1972).

    PubMed  CAS  Google Scholar 

  • Kessel, D.; Bruns, R. and Hall, T.C.: Determinants of responsiveness to 5-fluorouracil in transplantable murine leukemias. Molecular Pharmacology 7: 117–121 (1971).

    PubMed  CAS  Google Scholar 

  • Kessel, D.; Hall, T.C. and Rosenthal, D.: Uptake and phosphorylation of cytosine arabinoside by normal and leukemic human blood cells in vitro. Cancer Research 29: 459–463 (1969).

    PubMed  CAS  Google Scholar 

  • Kessel, D. and Wodinsky, I.: Thymidine kinase as a determinant of the response to 5-fluoro-2′-deoxyuridine in transplantable murine leukemias. Molecular Pharmacology 6: 251–254 (1970).

    PubMed  CAS  Google Scholar 

  • Kikuchi, H. and Sato, S.: Binding of daunomycin to nonhistone proteins from rat liver. Biochimica et Biophysica Acta 434: 509–512 (1976).

    PubMed  CAS  Google Scholar 

  • Kimelberg, H.K.; Biddlecombe, S.M. and Bourke, R.S.: Distribution and degradation of [3H] methotrexate after intravenous and cerebral intraventricular injection in primates. Cancer Research 37: 157–165 (1977).

    PubMed  CAS  Google Scholar 

  • King, L. and Sullivan, M.: Colchicine-like effect of podophyllotoxin. Science 10: 244–245 (1946).

    Google Scholar 

  • Koch-Weser, J. and Sellers, E.M.: Drug therapy: binding of drugs to serum albumin. New England Journal of Medicine 294: 311–316, 526-531 (1976).

    PubMed  CAS  Google Scholar 

  • Kociba, R.J. and Sleight, S.D.: Acute toxicologic and pathologic effects of cis-diamminedichloroplatinum (NSC-119875) in the male rat. Cancer Chemotherapy Reports 55: 1–8 (1971).

    CAS  Google Scholar 

  • Koenig, H. and Patel, A.: Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate. Archives of Neurology 23: 155–160 (1970).

    PubMed  CAS  Google Scholar 

  • Kraybill, W.G.; Harrison, M.; Sasaki, T. et al.: Regional intra-arterial infusion of adriamycin in the treatment of cancer. Surgery, Gynecology, and Obstetrics 144: 335–338 (1977).

    CAS  Google Scholar 

  • Kreis, W.; Woodcock, T.; Tan, C. et al.: Physiological distribution of tetrahydrouridine and its effects upon the deamination of arabinosylcytosine in humans. Proceedings of the American Association for Cancer Research 18: 226 (1977).

    Google Scholar 

  • Kremer, W.B.: Cytarabine. Annals of Internal Medicine 82: 684–688 (1975).

    PubMed  CAS  Google Scholar 

  • Krishan, A. and Frei, E.: Effect of adriamycin on the cell cycle traverse and kinetics of cultured human lymphoblasts. Cancer Research 36: 143–150 (1976).

    PubMed  CAS  Google Scholar 

  • Krishan, A.; Paika, K. and Frei, E.: Cytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblasts. Journal of Cell Biology 66: 521–530 (1975).

    PubMed  CAS  Google Scholar 

  • Kristensen, L.O.; Weismann, K. and Hutters, L.: Renal function and the rate of disappearance of methotrexate from serum. Europ. J. Clin. Pharmacol. 8: 439–444 (1975).

    CAS  Google Scholar 

  • Kupchan, S.M.; Komoda, Y.; Court, W.A. et al.: Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. Journal of the American Chemical Society 94: 1354–1356 (1972).

    PubMed  CAS  Google Scholar 

  • Kushner, J.P.; Hansen, V.L. and Hammar, S.P.: Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin D and mithramycin. Cancer 36: 1577–1584 (1975).

    PubMed  CAS  Google Scholar 

  • Lange, R.C.; Spencer, R.P. and Harder, H.C.: Synthesis and distribution of a radiolabeled antitumor agent: cis-diamminedichloroplatinum (II). Journal of Nuclear Medicine 13: 328–330 (1972).

    PubMed  CAS  Google Scholar 

  • Lange, R.C.; Spencer, R.P. and Harder, H.C.: The antitumor agent cis-PT(NH3)2Cl2: Distribution studies and dose calculations for 193mPt and l95mpt. Journal of Nuclear Medicine 14: 191–195 (1973).

    PubMed  CAS  Google Scholar 

  • Lee, T. and Momparler, R.L.: Kinetic studies with 5-azacytidine 5′-triphosphate and DNA dependent RNA polymerase. Biochemical Pharmacology 26: 403–406 (1977).

    PubMed  CAS  Google Scholar 

  • Lee, Y.C. and Byfield, J.E.: Induction of DNA degradation in vivo by adriamycin. Journal of the National Cancer Institute 57: 221–224 (1976).

    PubMed  CAS  Google Scholar 

  • Lefrak, E.A.; Pitha, J.; Rosenheim, S. et al.: A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32: 302–314 (1973).

    PubMed  CAS  Google Scholar 

  • Lenaz, L. and Page, J.A.: Cardiotoxicity of adriamycin and related anthracyclines. Cancer Treatment Reviews 3: 111–120 (1976).

    PubMed  CAS  Google Scholar 

  • Leonard, B.J. Eccleston, E.; Jones, D. et al.: Antileukaemic and nephrotoxic properties of platinum compounds. Nature 234: 43–45 (1971).

    PubMed  CAS  Google Scholar 

  • Levitan, I.B. and Webb, T.E.: Effects of 5-azacytidine on polyribosomes and on the control of tyrosine transaminase activity in rat liver. Biochimica et Biophysica Acta 182: 491–500 (1969).

    PubMed  CAS  Google Scholar 

  • Levitt, M.; Mosher, M.B.; DeConti, R.C. et al.: Improved therapeutic index of methotrexate with ‘leucovorin rescue’. Cancer Research 33: 1729–1734 (1973).

    PubMed  CAS  Google Scholar 

  • Levy, R.; Hurwitz, E.; Maron, R. et al.: The specific cytotoxic effects of daunomycin conjugated to antitumor antibodies. Cancer Research 35: 1182–1186 (1975).

    PubMed  CAS  Google Scholar 

  • Li, L.H.; Olin, E.J.; Buskirk, H.H. et al.: Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Research 30: 2760–2769 (1970a).

    PubMed  CAS  Google Scholar 

  • Li, L.H.; Olin, E.J.; Fraser, T.J. et al.: Phase specificity of 5-azacytidine against mammalian cells in tissue culture. Cancer Research 30: 2770–2775 (1970b).

    PubMed  CAS  Google Scholar 

  • Liegler, D.G.; Henderson, E.S.; Hahn, M.A. et al.: The effect of organic acids on renal clearance of methotrexate in man. Clinical Pharmacology and Therapeutics 10: 849–857 (1969).

    PubMed  CAS  Google Scholar 

  • Litterst, C.L.; Gram, T.E.; Dedrick, R.L. et al.: Distribution and disposition of platinum following intravenous administration of cis-diamminedichloroplatinum (II) (NSC-119875) to dogs. Cancer Research 36: 2340–2344 (1976).

    PubMed  CAS  Google Scholar 

  • Livingston, R.B. and Carter, S.K.::Single agents in cancer chemotherapy. Plenum Press, New York (1970).

    Google Scholar 

  • Loike, J.D. and Horwitz, S.B.: Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells. Biochemistry 15: 5435–5442 (1976a).

    PubMed  CAS  Google Scholar 

  • Loike, J.D. and Horwitz, S.B.: Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells. Biochemistry 15: 5443–5448 (1976b).

    PubMed  CAS  Google Scholar 

  • Lown, J.W.; Sim, S. and Majumdar, K.C.: Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents. Biochemical and Biophysical Research Communications 76: 705–710 (1977).

    PubMed  CAS  Google Scholar 

  • Mandelbaum-Shavit, F.; Wolpert-DeFilippes, M.K. and Johns, D.G.: Binding of Maytansine to rat brain tubulin. Biochemical and Biophysical Research Communications 72: 47–54 (1976).

    PubMed  CAS  Google Scholar 

  • Marquardt, H.; Philips, F.S. and Sterberg, S.S.: Tumorigenicity in vivo and induction of malignant transformation and mutogenesis in cell cultures by adriamycin and daunomycin. Cancer Research 36: 2065–2069 (1976).

    PubMed  CAS  Google Scholar 

  • McCredie, K.B.; Bodey, G.P.; Burgess, M.A. et al.: Treatment of acute leukemia with 5-azacytidine (NSC-102816). Cancer Chemotherapy Reports 57: 319–323 (1973).

    CAS  Google Scholar 

  • Mellett, L.B.: Chemistry and metabolism of cyclophosphamide; in Vancil (Ed) Immunosuppressive Properties of Cyclophosphamide, p.6–34 (Meade Johnson, Evansville, Ind. 1971).

    Google Scholar 

  • Merski, J.A.; Daskal, I. and Busch, H.: Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat. Cancer Research 36: 1580–1584 (1976).

    PubMed  CAS  Google Scholar 

  • Minow, R.A.; Benjamin, R.S.; Lee, E.T. et al.: Adriamycin cardiomyopathy risk factors. Cancer 39: 1397–1402 (1977).

    PubMed  CAS  Google Scholar 

  • Miyak, M.; Ono, T.; Hori, S. et al.: Binding of bleomycin to DNA in bleomycin-sensitive and -resistant rat ascites hepatoma cells. Cancer Research 35: 2015–2019 (1975).

    Google Scholar 

  • Moertel, C.G.: Clinical management of advanced gastrointestinal cancer. Cancer 36: 675–682 (1975).

    PubMed  CAS  Google Scholar 

  • Moertel, C.G.; Reitemeier, R.J. and Hahn, R.G.: A controlled comparison of 5-fluoro-2′-deoxyuridine therapy administered by rapid intravenous injection and by continuous intravenous infusion. Cancer Research 27: 549–552 (1967).

    PubMed  CAS  Google Scholar 

  • Momparler, R.L.: Kinetic and template studies with 1-β-D-arabinofuranosylcytosine 5′-triphosphate and mammalian deoxyribonucleic acid polymerase. Molecular Pharmacology 8: 362–370 (1972).

    PubMed  CAS  Google Scholar 

  • Momparler, R.L.: A model for the chemotherapy of acute leukemia with 1-β-D-arabinofuranosylcytosine. Cancer Research 34: 1775–1787 (1974).

    PubMed  CAS  Google Scholar 

  • Momparler, R.L.; Chu, M.Y. and Fischer, G.A.: Studies on a new mechanism of resistance of L1578Y murine leukemia cells to cytosine arabinoside. Biochimica et Biophysica Acta 161: 481–493 (1968).

    PubMed  CAS  Google Scholar 

  • Momparler, R.L.; Karon, M.; Siegel, S.E. et al.: Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Cancer Research 36: 2891–2895 (1976).

    PubMed  CAS  Google Scholar 

  • Mosher, M.B.; DeConti, R.C. and Bertino, J.R.: Bleomycin therapy in advanced Hodgkn’s disease and epidermoid cancers. Cancer 30: 56–60 (1972).

    PubMed  CAS  Google Scholar 

  • Muggia, F.M.; Selawry, O.S. and Hansen, H.H.: Clinical studies with a new podophyllotoxin derivative, epipodophyllotoxin, 4′demethyl-9-(4,6-0-2-thenylidene-β-D-glucopyranoside) (NSC-122819). Cancer Chemotherapy Reports 55: 575–581 (1971).

    CAS  Google Scholar 

  • Mukherjee, K.L.; Curreri, A.R.; Javid, M. et al.: Studies on fluorinated pyrimidines. XVII. Tissue distribution of 5-fluorouracil-2-C14 and 5-fluoro-2′-deoxyuridine in cancer patients. Cancer Research 23: 67–77 (1963).

    Google Scholar 

  • Mukherjee, K.L. and Heidelberger, C.: Studies on fluorinated pyrimidines. IX. The degradation of 5-fluorouracil-6-C14. Journal of Biological Chemistry 235: 433–437 (1960).

    PubMed  CAS  Google Scholar 

  • Mulder, J.H. and Harrap, K.R.: Cytosine arabinoside uptake by tumor cells in vitro. European Journal of Cancer 11: 373–379 (1975).

    PubMed  CAS  Google Scholar 

  • Munchausen, L.L.: The chemical and biological effects of cisdichlorodiammineplatinum (II), an antitumor agent, on DNA. Proceedings of the National Academy of Sciences U.S.A. 71: 4519–4522 (1974).

    CAS  Google Scholar 

  • Myers, C.E.; Lippman, M.E.; Eliot, H.M. et al.: Competitive protein binding assay for methotrexate. Proceedings of the National Academy of Sciences U.S.A. 72: 3683–3686 (1975).

    CAS  Google Scholar 

  • Myers, C.E.; Young, R.C. and Chabner, B.A.: Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion. Journal of Clinical Investigation 56: 1231–1238 (1975).

    PubMed  CAS  Google Scholar 

  • Nagai, K.; Suzuki, H.; Tanaka, N. et al.: Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of hydrogen peroxide. Journal of Antibiotics (Tokyo) 22: 624–628 (1969).

    CAS  Google Scholar 

  • Nahas, A.; Savlov, E.D. and Hall, T.C.: Phosphoribosyl transferase in colon tumor and normal mucosa as an aid in adjuvant chemotherapy with 5-fluorouracil (NSC-19893). Cancer Chemotherapy Reports 58: 909–912 (1974).

    CAS  Google Scholar 

  • Nelson, R.L.; Root, M.A.; Dyke, R.W. et al.: Pharmacokinetics of desacetyl vinblastine amide (Vindesine) in man. Proceedings of the American Association for Cancer Research 17: 30 (1976).

    Google Scholar 

  • Newsome, Y.L. and Singh, D.N.: Cytologic effects of adriamycin on human peripheral lymphocytes. Acta Cytologica 21: 137–140 (1977).

    PubMed  CAS  Google Scholar 

  • Nirenberg, A.; Mosende, C.; Mehta, B. et al.: High dose methotrexate with citrovorum factor rescue: Predictive value of serum methotrexate concentrations and corrective measures to avert toxicity. Cancer Treatment Reports 61: 779–783 (1977).

    PubMed  CAS  Google Scholar 

  • Nissen, N.I.; Dombernowsky, P.; Hansen, H.H. et al.: Phase I clinical trial of an oral solution of VP-16-213. Cancer Treatment Reports 60: 943–945 (1976).

    PubMed  CAS  Google Scholar 

  • Nissen, N.I.; Larsen, V.; Pedersen, H. et al.: Phase I clinical trial of a new antitumor agent, 4′-demethyl epipodophyllotoxin 9-(4,6-0-ethylidene-β-D-glucopyranoside) (NSC-141540; VP-16-213). Cancer Chemotherapy Reports 56: 769–777 (1972).

    CAS  Google Scholar 

  • Ohnuma, T.; Holland, J.F. and Chen, J.H.: Pharmacological and therapeutic efficacy of daunomycin-DNA complex in mice. Cancer Research 35: 1767–1772 (1975).

    PubMed  CAS  Google Scholar 

  • Overgaard, J.: Combined adriamycin and hyperthermia treatment of a murine mammary carcinoma in vivo. Cancer Research 36: 3077–3081 (1976).

    PubMed  CAS  Google Scholar 

  • Owellen, R.J. and Hartke, C.A.: The pharmacokinetics of 4-acetyltritium vinblastine in two patients. Cancer Research 35: 975–980 (1975).

    PubMed  CAS  Google Scholar 

  • Owellen, R.J.; Hartke, C.A. and Hains, F.O.: Pharmacokinetics and metabolism of vinblastine in humans. Cancer Research 37: 2597–2602 (1977a).

    PubMed  CAS  Google Scholar 

  • Owellen, R.J.; Owens, A.H. and Donigan, D.W.: The binding of vincristine, vinblastine, and colchicine to tubulin. Biochemical and Biophysical Research Communications 47: 685–691 (1972).

    PubMed  CAS  Google Scholar 

  • Owellen, R.J.; Root, M.A. and Hains, F.O.: Pharmacokinetics of vindesine and vincristine in humans. Cancer Research 37: 2603–2607 (1977b).

    PubMed  CAS  Google Scholar 

  • Pascoe, J.M. and Roberts, J.J.: Interactions between mammalian cell DNA and inorganic platinum compounds. Biochemical Pharmacology 23: 1345–1357 (1974).

    PubMed  CAS  Google Scholar 

  • Philips, F.S.; Gilladoga, A.; Marquardt, H. et al.: Some observations on the toxicity of adriamycin (NSC-123127). Cancer Chemotherapy Reports 6: 177–181 (1975).

    CAS  Google Scholar 

  • Piel, I.J.; Meyer, D.; Perlia, C.P. et al.: Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man. Cancer Chemotherapy Reports 58: 871–875 (1974).

    CAS  Google Scholar 

  • Pinedo, H.M. and Chabner, B.A.: The role of drug concentration, duration of exposure, and endogenous metabolites in determining MTX cytoxicity. Cancer Treatment Reports 61: 709–715 (1977).

    PubMed  CAS  Google Scholar 

  • Pinedo, H.M.; Zaharko, D.S.; Bull, J.M. et al.: The reversal of methotrexate cytotoxicity of mouse bone marrow cells by leucovorin and nucleosides. Cancer Research 36: 4418–4424 (1976).

    PubMed  CAS  Google Scholar 

  • Presant, C.A.; Klahr, C. and Santala, R.: Amphotericin B induction of sensitivity to adriamycin, l,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) plus cyclophosphamide in human neoplasia. Annals of Internal Medicine 86: 47–51 (1977).

    PubMed  CAS  Google Scholar 

  • Primack, A.: Amelioration of cyclophosphamide-induced cystitis. Journal of the National Cancer Institute 47: 223–227 (1971).

    PubMed  CAS  Google Scholar 

  • Quagliana, J.M.; O’Bryan, R.M.; Baker, L. et al.: Phase II study of 5-azacytidine in solid tumors. Cancer Chemotherapy Reports 61: 51–58 (1977).

    CAS  Google Scholar 

  • Ramos, A.; Meyer, R.A.; Korfhagen, J. et al.: Echocardiographic evaluation of adriamycin cardiotoxicity in children. Cancer Treatment Reports 60: 1281–1284 (1976).

    PubMed  CAS  Google Scholar 

  • Rashbaum, S.A. and Cozzarelli, N.R.: Mechanism of DNA synthesis inhibition by arabinosyl cytosine and arabinosyl adenine. Nature 264: 679–680 (1976).

    PubMed  CAS  Google Scholar 

  • Raso, V. and Schreiber, R.: A rapid and specific radioimmunoassay for methotrexate. Cancer Research 35: 1407–1410 (1975).

    PubMed  CAS  Google Scholar 

  • Reich, S.D. and Bachur, N.R.: Alterations in adriamycin efficacy by phenobarbital. Cancer Research 36: 3803–3806 (1976).

    PubMed  CAS  Google Scholar 

  • Reilly, M.J.: Drug information digest: Methotrexate USP (amethopterin) and methotrexate sodium. American Journal of Hospital Pharmacy 30: 542–548 (1973).

    Google Scholar 

  • Reimer, R.R.; Hoover, R.; Fraumeni, J.F. et al.: Acute leukemia after alkylating-agent therapy of ovarian cancer. New England Journal of Medicine 297: 177–181 (1977).

    PubMed  CAS  Google Scholar 

  • Reitemeier, R.J.; Moertel, C.G. and Hahn, R.G.: Comparison of 5-fluorouracil (NSC-19893) and 2′-deoxy-5-fluorouridine (NSC-27640) in the treatment of patients with advanced adenocarcinoma of colon or rectum. Cancer Chemotherapy Reports 44: 39–43 (1965).

    CAS  Google Scholar 

  • Remillard, S.; Rebhun, L.I.; Howie, G.A. et al.: Antitumor activity of the potent tumor inhibitor Maytansine. Science 189: 1002–1005 (1975).

    PubMed  CAS  Google Scholar 

  • Reslova, S.: The induction of lysogenic strains of Escherichia coli by cis-dichlorodiammine-platinum (II). Chemico-Biological Interactions 4: 66–70 (1971).

    PubMed  CAS  Google Scholar 

  • Reyes, P.: The synthesis of 5-fluorouridine-5′-phosphate by a pyrimidine phosphoribosyl transferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells. Biochemistry 8: 2057–2062 (1969).

    PubMed  CAS  Google Scholar 

  • Reyes, P. and Heidelberger, C.: Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: Its mechanism of action and inhibition by fluorinated nucleotides. Molecular Pharmacology 1: 14–30 (1965).

    PubMed  CAS  Google Scholar 

  • Richman, S.D.; Levenson, S.M.; Bunn, P.A. et al.: 67Ga-accumulation in pulmonary lesions associated with bleomycin toxicity. Cancer 36: 1966–1972 (1975).

    PubMed  CAS  Google Scholar 

  • Rinehart, J.J.; Lewis, R.P. and Balcerzak, S.P.: Adriamycin cardiotoxicity in man. Ann. Intern. Med. 81: 475–478 (1974).

    PubMed  CAS  Google Scholar 

  • Roberts, D.W. and Hall, T.C.: Triamterene-induced elevation of dihydrofolate reductase activity in human leukocytes. Biochemical Pharmacology 17: 484–487 (1968).

    Google Scholar 

  • Roberts, J.J. and Pascoe, J.M.: Cross-linking of complementary strands of DNA in mammalian cells by antitimour platinum compounds. Nature 235: 282–284 (1972).

    PubMed  CAS  Google Scholar 

  • Rosenberg, B.: Possible mechanism for the antitumor activity of platinum coordination complexes. Cancer Chemotherapy Reports 59: 589–598 (1975).

    Google Scholar 

  • Rosenberg, B.; Van Camp, L. and Krigas, T.: Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature 205: 698–699 (1965).

    PubMed  CAS  Google Scholar 

  • Rosenberg, B.; Van Camp, L.; Troska, J.E. et al.: Platinum compounds: a new class of potent antitumor agents. Nature 222: 385–386 (1969).

    PubMed  CAS  Google Scholar 

  • Rosenthal, S.M. and Kaufman, S.: Vincristine neurotoxicity. Annals of Internal Medicine 80: 733–737 (1974).

    PubMed  CAS  Google Scholar 

  • Rozencweig, M.; Von Hoff, D.D.; Henney, J.E. et al.: VM-26 and VP-16-213: A comparative analysis. Cancer 40: 334–342 (1977a).

    PubMed  CAS  Google Scholar 

  • Rozencweig, M.; Von Hoff, D.D.; Slavik, M. et al.: Cis-diamminedichloroplatinum (II). Annals of Internal Medicine 86: 803–812 (1977b).

    PubMed  CAS  Google Scholar 

  • Sadee, W. and Wong, C.G.: Pharmacokinetics of 5-fluorouracil: Inter-relationship with biochemical kinetics in monitoring therapy. Clinical Pharmacokinetics 2: 437–450 (1977).

    PubMed  CAS  Google Scholar 

  • Samuels, M.L.; Johnson, D.E. and Holoye, P.Y.: Continuous intravenous bleomycin (NSC-125066) therapy with vinblastine (NSC-49842) stage III testicular neoplasia. Cancer Chemotherapy Reports 59: 563–701 (1975).

    CAS  Google Scholar 

  • Santi, D.V.; McHenry, C.S. and Sommer, H.: Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 13: 471–481 (1974).

    PubMed  CAS  Google Scholar 

  • Schaeppi, U.; Heyman, I.A.; Fleischman, R.W. et al.: Cisdichlorodiammineplatinum (II) (NSC-119875): Preclinical toxicologic evaluation of intravenous injection in dogs, monkeys and mice. Toxicology and Applied Pharmacology 25: 230–241 (1973).

    PubMed  CAS  Google Scholar 

  • Seifert, P.; Baker, L.H.; Reed, M.L. et al.: Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma. Cancer 36: 123–128 (1975).

    PubMed  CAS  Google Scholar 

  • Shapiro, W.R., Yound, D.F. and Mehta, B.M.: Methotrexate: Distribution in cerebrospinal fluid and intravenous, ventricular, and lumbar injections. New England Journal of Medicine 293: 161–166 (1975).

    PubMed  CAS  Google Scholar 

  • Shindler, B.I.; Baig, M. and Colsky, J.: Phase I study of 5-azacytidine. Journal of Clinical Pharmacology 16: 205–212 (1976).

    Google Scholar 

  • Shooter, K.V.; Howse, R.; Merrifield, R.K. et al.: The interaction of platinum II compounds with bacteriophages T7 and R17. Chemico-Biological Interactions 5: 289–307 (1972).

    PubMed  CAS  Google Scholar 

  • Sieber, S.M. and Adamson, R.H.: Toxicity of antineoplastic agents in man. Chromosomal aberrations, antifertility effects, congenital malformations, and carcinogenic potential; in Klein; Weinhouse; Haddow (Eds) Advances in Cancer Research, p.57–155 (Academic Press, New York 1975).

    Google Scholar 

  • Skold, O.: Enzymatic ribosidation and ribotidation of 5-fluorouracil by extracts of the Ehrlich ascites tumor. Biochimica et Biophysica Acta 29: 651 (1958).

    PubMed  CAS  Google Scholar 

  • Skold, O.; Magnusson, P.H. and Revesz, L.: Studies on resistance against 5-fluorouracil. III. Selective value of resistant, uridine kinase-deficient tumor cells. Cancer Research 22: 1226–1229 (1962).

    PubMed  CAS  Google Scholar 

  • Sladek, N.E.: Therapeutic efficacy of cylophosphamide as a function of its metabolism. Cancer Research 32: 535–542 (1972).

    PubMed  CAS  Google Scholar 

  • Smart, C.R.; Townsend, L.B.; Rusho, W.J. et al.: Phase I study of ftorafur, an analog of 5-fluorouracil. Cancer 36: 103–106 (1975).

    PubMed  CAS  Google Scholar 

  • Smith, B.J. and Kundi, D.: Digoxin does not prevent daunorubicin or adriamycin from binding to rat heart muscle. British Journal of Cancer 33: 232–233 (1976).

    PubMed  CAS  Google Scholar 

  • Smith, P.H.S. and Taylor, D.M.: Distribution and retention of the antitumor agent ,95mPt-cis-dichlorodiammine platinum (II) in man. Journal of Nuclear Medicine 15; 349–351 (1974).

    PubMed  CAS  Google Scholar 

  • Smyth, J.F.; Robbins, A.B. and Leese, CL.: The metabolism of cytosine arabinoside as a predictive test for clinical response to the drugs in acute myeloid leukemia. European Journal of Cancer 12: 567–573 (1976).

    PubMed  CAS  Google Scholar 

  • Sostman, H.D.; Matthay, R.A.; Putnam, C.E. et al.: Methotrexate-induced pneumonitis. Medicine 55: 371–388 (1976).

    PubMed  CAS  Google Scholar 

  • Stadnicki, S.W.; Fleischman, R.W.; Schaeppi, U. et al.: Cisdichlorodiammineplatinum (II) (NSC-119875): Hearing loss and other toxic effects in rhesus monkeys. Cancer Chemotherapy Reports 59: 467–480 (1975).

    Google Scholar 

  • Stahelin, H.: 4′Demethyl-epipodophyllotoxin thenylidene glucoside (VM26), a podophyllin compound with a new mechanism of action. European Journal of Cancer 6: 303–311 (1970).

    PubMed  CAS  Google Scholar 

  • Stahelin, H.: Activity of a new glycosidic lignan derivative (VP-16-213) related to podophyllotoxin in experimental tumors. European Journal of Cancer 9: 212–221 (1973).

    Google Scholar 

  • Staquet, M.; Rozencweig, M.; Duarte-Karem, M. et al.: Pharmacokinetics of adriamycin and adriamycin-DNA complex in L1210 mice and men. European Journal of Cancer 13: 433–435 (1977).

    PubMed  CAS  Google Scholar 

  • Steuart, C.D. and Burke, P.J.: Cytidine deaminase and the development of resistance to arabinosyl cytosine. Nature [New Biology] 233: 109–110 (1971).

    CAS  Google Scholar 

  • Stevens, D.A.; Jordan, G.W.; Waddell, T.F. et al.: Adverse effect of cytosine arabinoside on disseminated zoster in a controlled trial. New England Journal of Medicine 289: 873–878 (1973).

    PubMed  CAS  Google Scholar 

  • Stolinsky, D.C.; Pugh, R.P. and Bateman, J.R.: 5-Fluorouracil (NSC-19893) therapy for pancreatic carcinoma: Comparison of oral and intravenous routes. Cancer Chemotherapy Reports 59: 1031–1033 (1975).

    CAS  Google Scholar 

  • Stoller, R.G.; Coleman, C.N.; Chang, P. et al.: Biochemical pharmacology of cytidine analog metabolism in human leukemic cells; in Clemmesen and Yohn (Eds) Bibliotheca Haematologica, p.531–533 (Basel, Karger 1976).

    Google Scholar 

  • Stoller, R.G.; Hande, K.R.; Jacobs, S.A. et al.: Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. New England Journal of Medicine 297: 630–634 (1977).

    PubMed  CAS  Google Scholar 

  • Stoller, R.G.; Jacobs, S.A.; Drake, J.C. et al.: Pharmacokinetics of high-dose methotrexate (NSC-740). Cancer Chemotherapy Reports 6: 19–24 (1975).

    Google Scholar 

  • Takanashi, S. and Bachur, N.R.: Adriamycin metabolism in man. Evidence from urinary metabolites. Drug Metabolism and Disposition 4: 79–87 (1976).

    PubMed  CAS  Google Scholar 

  • Talley, R.W.; (O’Bryan, R.M.; Gutterman, J.U. et al.: Clinical evaluation of toxic effects of cis-diamminedichloroplatinum (NSC-119875)-phase I clinical study. Cancer Chemotherapy Reports 57: 465–471 (1973).

    CAS  Google Scholar 

  • Tanlon, R.N.; Bunnell, I.L. and Cooper, R.G.: The treatment of metastatic carcinoma of the liver by the percutaneous selective hepatic artery infusion of 5-fluorouracil. Surgery 73: 118–121 (1973).

    Google Scholar 

  • Tattersall, M.H.; Ganeshaguru, K. and Hoffbrand, A.V.: Mechanisms of resistance of human acute leukemia cells to cytosine arabinoside. British Journal of Haematology 27: 39–46 (1974).

    PubMed  CAS  Google Scholar 

  • Thomson, A.J.; Williams, R.J.P. and Reslova, S.: The chemistry of complexes related to cis-Pt (NH3)2C12. An antitumor drug. Structure and Bonding 11: 1–46 (1972).

    CAS  Google Scholar 

  • Thomson, A.J.: The interactions of platinum compounds with biological molecules. Recent Results in Cancer Research 48: 38–62 (1974).

    CAS  Google Scholar 

  • Thompson, H.S. and Gale, G.R.: Cis-dichlorodiammineplatinum (II): Hematopoietic effects in rats. Toxicology and Applied Pharmacology 19: 602–609 (1971).

    PubMed  CAS  Google Scholar 

  • Troetel, W.M.; Weiss, A.J.; Stambaugh, J.E. et al.: Absorption, distribution, and excretion of 5-azacytidine (NSC-102816) in man. Cancer Chemotherapy Reports 56: 405–411 (1972).

    CAS  Google Scholar 

  • Trouet, A.; Deprez De Campaneere, D. and De Duve, C.: Chemotherapy through lysosomes with a DNA-daunorubicin complex. Nature [New Biology] 239: 110–112 (1972).

    CAS  Google Scholar 

  • Umezawa, H.: Chemistry and mechanism of action of bleomycin. Federation Proceedings 33: 2296–2302 (1974).

    PubMed  CAS  Google Scholar 

  • Umezawa, H.; Hori, S.; Sawa, T. et al.: A bleomycin-inactivating enzyme in mouse liver. Journal of Antibiotics 27: 419–424 (1974).

    PubMed  CAS  Google Scholar 

  • Valdivieso, M.; Bodey, G.P.; Gottlieb, J.A. et al.: Clinical evaluation of ftorafur (pyrimidine-deoxyribose N1-2′-furanidyl-5-fluorouracil). Cancer Research 36: 1821–1824 (1976).

    PubMed  CAS  Google Scholar 

  • Van den Berg, H.W. and Roberts, J.J.: Investigations into the mechanism of action of antitumor platinum compounds: Time- and dose-dependent changes in the alkaline sucrose gradient sedimentation profiles of DNA from hamster cells treated with cis-platinum (II) diamminedichloride. Chemico-Biological Interactions 11: 493–499 (1975).

    PubMed  Google Scholar 

  • Van den Berg, H.W. and Roberts, J.J.: Inhibition by caffeine of post-replication repair in Chinese hamster cells treated with cis-platinum (II) diamminedichloride: The extent of platinum binding to template DNA in relation to the size of low molecular weight nascent DNA. Chemico-Biological Interactions 12: 375–390 (1976).

    Google Scholar 

  • Vesely, J.; Cihak, A. and Sorm, F.: Association of decreased uridine and deoxycytidine kinase with enhanced RNA and DNA polymerase in mouse leukemic cells resistant to 5-azacytidine and 5-ara-2′-deoxycytidine. Cancer Research 30: 2180–2186 (1970).

    PubMed  CAS  Google Scholar 

  • Vogler, W.R.; Miller, D.S. and Keller, J.W.: 5-Azacytidine: A new drug for the treatment of myeloblasts leukemia. Blood 48: 331–337 (1976).

    PubMed  CAS  Google Scholar 

  • Von Hoff, D.D.; Penta, J.S.; Helman, L.J. et al.: The incidence of drug related deaths secondary to high dose methotrexate and citrovorum administration. Cancer Treatment Reports 61: 745–748 (1977a).

    Google Scholar 

  • Von Hoff, D.D.; Rozencweig, M.; Layard, M. et al.: Daunomycin-induced cardiotoxicity in children and adults. American Journal of Medicine 62: 200–208 (1977b).

    Google Scholar 

  • Von Hoff, D.D.; Slavik, M. and Muggia, F.M.: 5-Azacytidine: A new anticancer drug with effectiveness in acute myelogenous leukemia. Annals of Internal Medicine 85: 237–245 (1976a).

    Google Scholar 

  • Von Hoff, D.D.; Slavik, M. and Muggia, F.M.: Allergic reactions to cis-platinum. Lancet 1: 90 (1976b).

    Google Scholar 

  • Wan, S.H.; Huffman, D.H.; Azarnoff, D.L.; Stephens, R. and Hoogstraten, B.: Effect of route of administration and effusions on methotrexate pharmacokinetics. Cancer Research 34: 3487–3491 (1974).

    PubMed  CAS  Google Scholar 

  • Ward, J.M.; Arabin, M.E.; Berlin, E. et al.: Prevention of renal failure in rats receiving cisdiamminedichloroplatinum (II) by administration of furosemide. Cancer Research 37: 1238–1240 (1977).

    PubMed  CAS  Google Scholar 

  • Ward, J.M. and Fauvie, K.A.: The nephrotoxic effects of cis-diamminedichloroplatinum (II) (NSC-1 19875) in male F344 rats. Toxicology and Applied Pharmacology 38: 535–547 (1976).

    PubMed  CAS  Google Scholar 

  • Warren, R.D.; Nichols, A.P. and Bender, R.A.: The effect of vincristine on methotrexate uptake and inhibition of DNA synthesis by human lymphoblastoid cells. Cancer Research. 37: 2993–2997 (1977).

    PubMed  CAS  Google Scholar 

  • Weiss, A.J.; Metter, G.E., Fletcher, W.S. et al.: Studies on adriamycin using a weekly regimen demonstrating its clinical effectiveness and lack of cardiac toxicity. Cancer Treatment Reports 60: 813–822 (1976).

    PubMed  CAS  Google Scholar 

  • Weiss, H.D.; Walker, M.D. and Wiernik, P.H.: Neurotoxicity of commonly used antineoplastic agents. New England Journal of Medicine 291: 75–81, 127–133 (1974).

    PubMed  CAS  Google Scholar 

  • Wilson, D.W.; Guer, D.; Reimer, R. et al.: Structure-activity relationship of daunorubicin and its peptide derivatives. Journal of Medicinal Chemistry 19: 381–384 (1976).

    PubMed  CAS  Google Scholar 

  • Wolpert-DeFilippes, M.K.; Adamson, R.H.; Cysyk, R.L. et al.: Initial studies on the cytotoxic action of Maytansine, a novel ansa macrolide. Biochemical Pharmacology 24: 751–754 (1975a).

    PubMed  CAS  Google Scholar 

  • Wolpert-DeFilippes, M.K.; Bono, V.H.; Dion, R.L. et al.: Initial studies on Maytansine-induced metaphase arrest in L1210 murine leukemia cells. Biochemical Pharmacology 24: 1735–1738 (1975b).

    PubMed  CAS  Google Scholar 

  • Woodman, R.J.; Cysyk, R.L.; Kline, I. et al.: Enhancement of the effectiveness of daunorubicin (NSC-82151) or adriamycin (NSC-123127) against early mouse L1210 leukemia with ICRF-59 (NSC-129943). Cancer Chemotherapy Reports 59: 689–695 (1975).

    CAS  Google Scholar 

  • Young, R.C.: Chemotherapy of ovarian cancer: Past and present. Seminars in Oncology 2: 267–276 (1975).

    PubMed  CAS  Google Scholar 

  • Young, R.C.; Rosenoff, S.A.; Myers, C.E. et al.: Alterations in DNA synthesis induced by chemotherapeutic agents in vivo: Potential applications to clinical treatment schedules; in Growth Kinetics and Biochemical Regulation of Normal and Malignant Cells, University of Texas System Cancer Center, MD Anderson Hospital and Tumor Institute at Houston, (Williams and Wilkins, Baltimore 1976).

    Google Scholar 

  • Zager, R.F.; Frisby, S.A. and Oliverio, V.T.: The effects of antibiotics and cancer chemotherapeutic agents on the cellular transport and antitumor activity of methotrexate in L1210 murine leukemia. Cancer Research 33: 1670–1676 (1973).

    PubMed  CAS  Google Scholar 

  • Zaharko, D.S.; Bruchner, H. and Oliverio, V.T.: Antibiotics alter methotrexate metabolism and excretion. Science 166: 887–888 (1969).

    PubMed  CAS  Google Scholar 

  • Zaharko, D.S.; Fung, W-P. and Yang, K-H.: Relative biochemical aspects of low and high doses of methotrexate in mice. Cancer Research 37: 1602–1607 (1977).

    PubMed  CAS  Google Scholar 

  • Zak, M.; Drobnik, J. and Rezny, Z.: The effect of cisdichlorodiammineplatinum (II) of cytological and morphological changes in bone marrow of mice (long-term observations). Neoplasma 19: 305–310 (1972a).

    PubMed  CAS  Google Scholar 

  • Zak, M.; Drobnik, J. and Rezny, Z.: The effect of cis-platinum (II) diamminodichloride on bone marrow. Cancer Research 32: 595–599 (1972b).

    PubMed  CAS  Google Scholar 

  • Zunino, F.; Gambetta, R.; DiMarco, A. et al.: Interaction of daunomycin and its derivatives with DNA. Biochimica et Biophysica Acta 277: 489–498 (1972).

    PubMed  CAS  Google Scholar 

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  1. Medicine Branch and Clinical Pharmacology Branch, National Cancer Institute, Building 10, Room 12N226, 9000 Rockville Pike, Bethesda, Maryland, 20014, USA

    Richard A. Bender, Leonard A. Zwelling, James H. Doroshow, Gershon Y. Locker, Kenneth R. Hande, Donald S. Murinson, Michael Cohen, Charles E. Myers & Bruce A. Chabner

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  1. Richard A. Bender
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  2. Leonard A. Zwelling
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  3. James H. Doroshow
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  4. Gershon Y. Locker
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  5. Kenneth R. Hande
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Bender, R.A., Zwelling, L.A., Doroshow, J.H. et al. Antineoplastic Drugs: Clinical Pharmacology and Therapeutic Use. Drugs 16, 46–87 (1978). https://doi.org/10.2165/00003495-197816010-00003

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