, Volume 15, Supplement 1, pp 30–32 | Cite as

Single Dose Therapy of Giardiasis with Tinidazole and Metronidazole

  • A. J. Gazder
  • Meenakshi Banerjee
Session IV: Giardiasis, Amoebiasis and Trichomoniasis Chairman: Dr J. Y. Perez, Jr (Manila)


In random order, a single dose of either tinidazole or metronidazole, calculated as 50mg/kg body weight, was given to 100 children with symptomatic giardiasis. Follow-up was done for 16 days and consisted of 4 clinical, parasitological and biochemical assessments at intervals of 4 days. The actual mean dose of the drugs received by the patients was 55.5mg/kg of tinidazole and 52.0mg/kg of metronidazole. Success, i.e. parasitic clearance and symptomatic relief was achieved in 80 % of patients given tinidazole as opposed to 36 % of patients given metronidazole (p < 0.01). Moreover, control of diarrhoea and negative stool conversion for G. lamblia occurred earlier with tinidazole than with metronidazole (p < 0.01). The incidence of gastrointestinal side-effects was 12% for tinidazole and 4% for metronidazole. Neither drug caused any abnormality of the blood count, blood urea, urine analysis or liver function tests.


Metronidazole Tinidazole Parasitic Clearance Giardiasis Trichomoniasis 
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Copyright information

© ASIS Press 1978

Authors and Affiliations

  • A. J. Gazder
    • 1
  • Meenakshi Banerjee
    • 1
  1. 1.Calcutta National Medical College and Chittaranjan HospitalCalcuttaIndia

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