Drugs

, Volume 15, Supplement 1, pp 30–32 | Cite as

Single Dose Therapy of Giardiasis with Tinidazole and Metronidazole

  • A. J. Gazder
  • Meenakshi Banerjee
Session IV: Giardiasis, Amoebiasis and Trichomoniasis Chairman: Dr J. Y. Perez, Jr (Manila)

Summary

In random order, a single dose of either tinidazole or metronidazole, calculated as 50mg/kg body weight, was given to 100 children with symptomatic giardiasis. Follow-up was done for 16 days and consisted of 4 clinical, parasitological and biochemical assessments at intervals of 4 days. The actual mean dose of the drugs received by the patients was 55.5mg/kg of tinidazole and 52.0mg/kg of metronidazole. Success, i.e. parasitic clearance and symptomatic relief was achieved in 80 % of patients given tinidazole as opposed to 36 % of patients given metronidazole (p < 0.01). Moreover, control of diarrhoea and negative stool conversion for G. lamblia occurred earlier with tinidazole than with metronidazole (p < 0.01). The incidence of gastrointestinal side-effects was 12% for tinidazole and 4% for metronidazole. Neither drug caused any abnormality of the blood count, blood urea, urine analysis or liver function tests.

Keywords

Metronidazole Tinidazole Parasitic Clearance Giardiasis Trichomoniasis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Antia, F.P.: Foreword to special number on giardiasis. Indian Practitioner 23: 119 (1970).Google Scholar
  2. Brandborg, L.L.; Tankersley, C.B.; Gottlieb, S. et al.: Histological demonstration of mucosal invasion by Giardia lamblia in man. Gastroenterology 52: 143–150 (1967).PubMedGoogle Scholar
  3. Brown, H.W.: Basic Clinical Parasitology, 3rd ed., p.40 (Meredith Publishing Co., New York 1961).Google Scholar
  4. Chakravarti, A.: Giardiasis and its treatment with particular reference to Flagyl therapy. Indian Practitioner 21: 808–814 (1970).Google Scholar
  5. Dalai, N.J.; Vakil, B.J.; Gangrade, R.R.; Enjetti, E.E. and Shah, P.N.: Single dose therapy with metronidazole in giardiasis. Indian Practitioner 30: 113–115 (1977).Google Scholar
  6. Jokipii, A.M.M. and Jokipii, L.: Prepatency of giardiasis. Lancet 1: 1095–1097 (1977).PubMedCrossRefGoogle Scholar
  7. Monro, A.M.: Blood levels of chemotherapeutic drugs and the pharmacokinetics of tinidazole and metronidazole. Current Medical Research and Opinion 2: 130–137 (1974).PubMedCrossRefGoogle Scholar
  8. Pettersson, T.: Single-dose tinidazole therapy for giardiasis. British Medical Journal 1: 395 (1975).PubMedCrossRefGoogle Scholar
  9. Sardesai, H.V.: Giardiasis — a study of clinical features and its treatment with metronidazole. Indian Practitioner 23: 171 (1970).Google Scholar
  10. Schultz, M.G.: Giardiasis. Journal of the American Medical Association 233: 1383–1384 (1975).CrossRefGoogle Scholar

Copyright information

© ASIS Press 1978

Authors and Affiliations

  • A. J. Gazder
    • 1
  • Meenakshi Banerjee
    • 1
  1. 1.Calcutta National Medical College and Chittaranjan HospitalCalcuttaIndia

Personalised recommendations